DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TYK2 and tyk2

DIOPT Version :9

Sequence 1:	NP_001372133.1	Gene:	TYK2 / 7297	HGNCID:	12440	Length:	1257	Species:	Homo sapiens
Sequence 2:	XP_002939720.2	Gene:	tyk2 / 100489432	XenbaseID:	XB-GENE-993652	Length:	1179	Species:	Xenopus tropicalis

Alignment Length:	1256	Identity:	707/1256 - (56%)
Similarity:	878/1256 - (69%)	Gaps:	125/1256 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    27 GLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHIL 91
            ||:|.|:|:  .|.|.:||:|:..:|||:|||||:.::||||.|:..|||:|...:.|.||:|:.
Frog    24 GLRVFLYWS--NGKEHYVTYSQGEITAEDVCIHISERLGITPLCYTFFALYDVHGKYWYPPDHVF 86

Human    92 EIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQT--AQGMQLLDPASFEYLFE 154
            .:.:|..|.|:||:|:|||||||||.:||.|:|..|...:.|.|::  .|...:||.||||||||
Frog    87 TVTKDMKLFLHFRMRYYFRNWHGMNEKEPVVFRNVPKSRDGSEDRSRIEQAGAILDLASFEYLFE 151

Human   155 QGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSF 219
            |||.:|||||.||.:.|.|::||.|||||||||.|||.|:|::..:.||||||:.|||:|||:||
Frog   152 QGKFDFVNDVVSLKDFSMEQDIHRFKNESLGMAVLHLSHIAIKKKVSLEEVAKQISFKECIPKSF 216

Human   220 RRHIRQHSALTRLRLRNVFRRFLRDF-----QPGRLSQQMVMVKYLATLERLAPRFGTERVPVCH 279
            .|.|:|::.||:.|::|||::|:|.|     .||:|:::.:|.|||:|||.||||.|.|......
Frog   217 CRQIQQNNYLTKFRMKNVFKKFVRRFHLHTVSPGKLNEEDIMYKYLSTLENLAPRLGCEVFKALS 281

Human   280 LRLLAQAEGEPCYIRDSGVAPTDP---GPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSG 341
            |.|.|:.|..|.|:....:..||.   .|.|     ||:|:|:|..|||:     .::|||..:.
Frog   282 LELPAEGEKLPFYLNGGYMEHTDTVNREPTS-----THQVMVSGMEGIQY-----RISKEEEDTE 336

Human   342 SSGRNPQASLFGKKA--KAHKAV-GQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCL 403
            :|   .|...|.||:  |..||: .|......||.|..||||:||||:|:.:..||:..|||:||
Frog   337 TS---TQRHYFSKKSRVKGQKALKSQQLPGKSEPKWVTFCDFQDITHIVISKSRVSVSCQDNRCL 398

Human   404 ELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLR--- 465
            |::|.|...|||||||||||||||.||:|||||||||||||:|:.:||||||.|.:|..||:
Frog   399 EIALHSCEDALSFVSLVDGYFRLTTDSNHYLCHEVAPPRLVLSVANGIHGPLQEQYVAQKLKREE 463

Human   466 PEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELG 530
            .|:|||:|.||......:|:.|...:|:    :....::|.||::.|.|.||.|.|.|.||:||.
Frog   464 QEEGLYIIRWSAFSFNIIIMAVKSVTQS----KGFTYKQFKIEKKGGVFSLEDWDREFHSVKELV 524

Human   531 AALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGA-----RASPRTLNLSQLSFHRVDQKEIT 590
            .:|:||.|::|.|.|::::|.||:.||.|||.|.|..     |...:.|||||||||::.:.||.
Frog   525 ESLRGCTLKSGKDTFTVKKCILPKSGEVSNLTISRRGKNNRERTVSKNLNLSQLSFHQIRKHEIL 589

Human   591 QLSHLGQGTRTNVYEGRLRV-EGS---GDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDI 651
            |.||||||||||:|:|.|.| |||   .|.|.|:::         :...:||||||||||||.||
Frog   590 QKSHLGQGTRTNIYDGMLLVTEGSEHESDYESGELN---------NNSHDLRVVLKVLDPSHRDI 645

Human   652 ALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQ 716
            ||||:|||||||||||.||.||||||||..|||||.|::|||||||.||:::..:...||..||:
Frog   646 ALAFFETASLMSQVSHIHLVFVHGVCVRESENIMVEEFIEHGPLDVCLRKDKLKIKAEWKFTVAR 710

Human   717 QLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAP 781
            ||||||||||:|||||||||.:||||||.||.|.:|||||||||||....||||||||||||:||
Frog   711 QLASALSYLEDKNLVHGNVCAKNILLARKGLEENSSPFIKLSDPGVTFTVLSREERVERIPWIAP 775

Human   782 ECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEVCLGDPWALPAVGAPPRNPEDRIR 846
            ||: ...:||||..|||.||.|||||||:||.||:.|:|.|
Frog   776 ECV-RNISSLSTTADKWSFGTTLLEICFNGEVPLKERTPPE------------------------ 815

Human   847 AQSCIPSGLVTSSLSGLPAGGPLAGAQCSPSLFRSLWKSLVPGTQKKEHFYQRQHRLPEPSCPQL 911
                                                          ||.||:::..||||||.:|
Frog   816 ----------------------------------------------KERFYEKELGLPEPSCKEL 834

Human   912 ATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEG 976
            |.|..||..|.|..|||||||||:||:|||..|.|:.|::|.| .:|||||.||||||||:||||
Frog   835 ADLIGQCHNYNPEGRPSFRTILRELTQLQPDVLPDIATISPVS-ITDPTVFQKRYLKKIRELGEG 898

Human   977 HFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGE 1041
            ||||||||||||.|||||||||||:||:.|..|..|.||.||.||:|||||:|:||||||.:||:
Frog   899 HFGKVSLYCYDPNNDGTGEMVAVKSLKSGCSQQLESSWKGEIKILKTLYHENIVKYKGCCSEQGD 963

Human  1042 KSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRL 1106
            |.:||:||||||||||||||:|::.|||:|||||||||||||||:||||||||||||||::|:.:
Frog   964 KIVQLIMEYVPLGSLRDYLPKHNVSLAQILLFAQQICEGMAYLHSQHYIHRDLAARNVLVENENV 1028

Human  1107 VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSS 1171
            |||||||||||||||||||||||||||||||||.|||||.||:|||||||||||.|||||.|||.
Frog  1029 VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYATECLKECKFFYASDVWSFGVTFYELLTRCDSY 1093

Human  1172 QSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLI 1236
            .|||:||:|:||:.||||||:||.:|||||:|||.|..||.|:|.||||||||||:|||||.:||
Frog  1094 LSPPSKFIEMIGVTQGQMTVVRLIDLLERGQRLPCPSDCPLEIYKLMKNCWETEANFRPTFNHLI 1158

Human  1237 PILKTVHEKYQGQAPSVFSVC 1257
            ||||:....|..|||||||:|
Frog  1159 PILKSFVNTYSTQAPSVFSLC 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TYK2	NP_001372133.1	FERM_F1	28..125	CDD:408179	48/96 (50%)
		FERM_F2	143..266	CDD:408177	74/127 (58%)
		Jak1_Phl	285..432	CDD:407742	66/152 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..366		12/33 (36%)
		SH2	437..534	CDD:417686	43/99 (43%)
		PKc_like	589..937	CDD:419665	184/351 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..629		7/22 (32%)
		PTKc_Tyk2_rpt2	962..1244	CDD:270664	221/281 (79%)
tyk2	XP_002939720.2	FERM_F1	25..115	CDD:375805	45/91 (49%)
		FERM_F2	139..268	CDD:375803	74/128 (58%)
		PH-like	273..432	CDD:388408	75/171 (44%)
		SH2	432..528	CDD:387587	43/99 (43%)
		PTK_Tyk2_rpt1	588..860	CDD:270661	184/351 (52%)
		PTKc_Tyk2_rpt2	884..1166	CDD:270664	221/281 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	469	1.000	Domainoid score	I4323
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20712
Inparanoid	1	1.050	1394	1.000	Inparanoid score	I1657
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31031at32523
OrthoFinder	1	1.000	-	-		FOG0001105
OrthoInspector	1	1.000	-	-		oto154867
Panther	1	1.100	-	-	LDO	PTHR45807
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X669
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160