| Sequence 1: | NP_001372133.1 | Gene: | TYK2 / 7297 | HGNCID: | 12440 | Length: | 1257 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001244276.1 | Gene: | Tyk2 / 100361294 | RGDID: | 2320469 | Length: | 1186 | Species: | Rattus norvegicus |
| Alignment Length: | 1247 | Identity: | 942/1247 - (75%) |
|---|---|---|---|
| Similarity: | 1026/1247 - (82%) | Gaps: | 78/1247 - (6%) |
- Green bases have known domain annotations that are detailed below.
|
Human 12 SKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFAL 76
Human 77 FDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGM 141
Human 142 QLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVA 206
Human 207 KKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFG 271
Human 272 TERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKE 336
Human 337 EGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNK 401
Human 402 CLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRP 466
Human 467 EDGLYLIHWSTSHPYRLILTVAQRSQAP-DGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELG 530
Human 531 AALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHL 595
Human 596 GQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS 660
Human 661 LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYL 725
Human 726 ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANS 790
Human 791 LSTAMDKWGFGATLLEICFDGEAPLQSRSPSEVCLGDPWALPAVGAPPRNPEDRIRAQSCIPSGL 855
Human 856 VTSSLSGLPAGGPLAGAQCSPSLFRSLWKSLVPGTQKKEHFYQRQHRLPEPSCPQLATLTSQCLT 920
Human 921 YEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYC 985
Human 986 YDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEY 1050
Human 1051 VPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLA 1115
Human 1116 KAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLE 1180
Human 1181 LIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEK 1245
Human 1246 YQGQAPSVFSVC 1257 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| TYK2 | NP_001372133.1 | FERM_F1 | 28..125 | CDD:408179 | 78/96 (81%) |
| FERM_F2 | 143..266 | CDD:408177 | 99/122 (81%) | ||
| Jak1_Phl | 285..432 | CDD:407742 | 90/146 (62%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 335..366 | 11/30 (37%) | |||
| SH2 | 437..534 | CDD:417686 | 70/97 (72%) | ||
| PKc_like | 589..937 | CDD:419665 | 231/347 (67%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 610..629 | 8/18 (44%) | |||
| PTKc_Tyk2_rpt2 | 962..1244 | CDD:270664 | 259/281 (92%) | ||
| Tyk2 | NP_001244276.1 | FERM_F1 | 33..130 | CDD:408179 | 78/96 (81%) |
| FERM_F2 | 148..271 | CDD:408177 | 99/122 (81%) | ||
| Jak1_Phl | 290..433 | CDD:407742 | 90/146 (62%) | ||
| SH2 | 438..536 | CDD:417686 | 70/97 (72%) | ||
| PKc_like | 591..866 | CDD:419665 | 231/347 (67%) | ||
| PTKc_Tyk2_rpt2 | 891..1173 | CDD:270664 | 259/281 (92%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C83678634 | |
| Domainoid | 1 | 1.000 | 541 | 1.000 | Domainoid score | I6054 |
| eggNOG | 1 | 0.900 | - | - | E2759_KOG0197 | |
| HGNC | 1 | 1.500 | - | - | ||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H20712 | |
| Inparanoid | 1 | 1.050 | 1941 | 1.000 | Inparanoid score | I1565 |
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG47769 | |
| OrthoDB | 1 | 1.010 | - | - | D20872at9347 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001105 | |
| OrthoInspector | 1 | 1.000 | - | - | oto138010 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100013 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR45807 |
| Phylome | 1 | 0.910 | - | - | ||
| SonicParanoid | 1 | 1.000 | - | - | X669 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 17 | 17.310 | |||||