DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TXK and tec

DIOPT Version :9

Sequence 1:	XP_024309968.1	Gene:	TXK / 7294	HGNCID:	12434	Length:	530	Species:	Homo sapiens
Sequence 2:	NP_001108215.1	Gene:	tec / 571588	ZFINID:	ZDB-GENE-030131-7499	Length:	622	Species:	Danio rerio

Alignment Length:	460	Identity:	265/460 - (57%)
Similarity:	339/460 - (73%)	Gaps:	28/460 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    72 RKPLPPL----------------PPSEVAEEKIQ-----VKALYDFLPREPCNLALRRAEEYLIL 115
            ||||||:                ||.|..:|:.:     |.|||||...||.:|.|:..|||:||
Zfish   154 RKPLPPVPEDQNISCTGRRPPPPPPGETKQEEEEPEEEVVIALYDFEGLEPHDLTLKTGEEYVIL 218

Human   116 EKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRD 180
            ||...:|:|||::.|.:|.||||||||.....||.:.|:.:|:.||:||.|||:|.|||.|:||.
Zfish   219 EKCEVNWYKARNKEGKQGYIPSNYVTEKASDKLEQFIWFSKNVNRNKAEELLRKEGKEGGFMVRL 283

Human   181 SRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSG--QWYVAERHAFQSIPELIWYHQHNAAGLMT 243
            |.:.|:||:|::..:.....|||:|||||:..:.  |:|:||::.|.||||||.||:||||||::
Zfish   284 SSNTGTYTVSLYTKSTSDGAAAIRHYQIKEIHASPKQFYLAEKYIFTSIPELIEYHKHNAAGLVS 348

Human   244 RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGS 308
            |||:.||......|.||||||:||||:||||.|:||:||||||||.||:||:..:||||.|.||:
Zfish   349 RLRHAVGDQKREAPTTAGFSYDKWEINPSELTFMKELGSGQFGVVRLGKWRAQHKVAIKTIREGA 413

Human   309 MSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSV 373
            |||:|||||||:||.|||..||||||||.|:||:|:||||||.|||||:||:.:|.|..:.||.:
Zfish   414 MSEDDFIEEAKIMMNLSHRNLVQLYGVCTQQKPIYLVTEFMELGCLLNFLRQRRGTLAAQDLLGI 478

Human   374 CQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPP 438
            |.||.:||::||.|.:||||||||||||:::.:||:||||||||||||:|.||.|.|||:|||||
Zfish   479 CHDISQGMQHLEENRFIHRDLAARNCLVNTSMVVKVSDFGMTRYVLDDQYWSSSGTKFPVKWSPP 543

Human   439 EVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMY 503
            |||.|.:||||||||||||||||||||||||||:..|.:||..:::|.|||||..:..|..:
Zfish   544 EVFNFCRYSSKSDVWSFGVLMWEVFTEGKMPFEHSQNHEVVLMVTQGHRLYRPKKSSSSHLQ--- 605

Human   504 SCWHE 508
              :||
Zfish   606 --YHE 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TXK	XP_024309968.1	SH3_TXK	88..142	CDD:212840	29/58 (50%)
		SH2_Tec_Txk	146..251	CDD:198261	54/106 (51%)
		PTKc_Tec_like	269..524	CDD:173637	159/240 (66%)
tec	NP_001108215.1	PH	6..111	CDD:278594
		PH_Btk	7..148	CDD:269944
		SH3_Tec	192..246	CDD:212838	30/53 (57%)
		SH2_Tec_Itk	249..356	CDD:198259	54/106 (51%)
		PKc_like	374..602	CDD:304357	156/227 (69%)
		Pkinase_Tyr	379..602	CDD:285015	152/222 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I32944
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52659
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.030