DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TXK and Txk

DIOPT Version :9

Sequence 1:	XP_024309968.1	Gene:	TXK / 7294	HGNCID:	12434	Length:	530	Species:	Homo sapiens
Sequence 2:	NP_001019426.1	Gene:	Txk / 305311	RGDID:	1306481	Length:	526	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	418/506 - (82%)
Similarity:	465/506 - (91%)	Gaps:	1/506 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    25 QMRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQ 89
            |.|::.|:||||.:|||.||::||:|.|.|:|..|.||:.|.||||||:||||| |.|..||:|:
  Rat    22 QGRRVTTRISLSREEELSEKHSQRQRQWFSKLMGKSQSSRGGVQPSKRRPLPPL-PQEFTEERIR 85

Human    90 VKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWY 154
            |||||||||||||||||:|||||||||:.:||||:|||||||||||||||||||::||||.||||
  Rat    86 VKALYDFLPREPCNLALKRAEEYLILERCDPHWWRARDRLGNEGLIPSNYVTENRLTNLETYEWY 150

Human   155 HRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVA 219
            |:||||:|.|.|||||:|||||||||||||||||||||..|||.|:::||||||||||||||||.
  Rat   151 HKNITRDQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYVT 215

Human   220 ERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQ 284
            |||.|.|:||||.|||:||||||:||||||||:|||||||:||||||||||||||.|:|||||||
  Rat   216 ERHLFPSVPELIQYHQYNAAGLMSRLRYPVGLLGSCLPATSGFSYEKWEIDPSELTFVKEIGSGQ 280

Human   285 FGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFM 349
            ||||:|||||:.|:|||||||||||||||||||||||||||||:||||||||||:||||||||||
  Rat   281 FGVVYLGEWRARIRVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTEFM 345

Human   350 ENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGM 414
            ||||||:||||.||||.|.:|||:||||||||.|||::.|||||||||||||||.|:||||||||
  Rat   346 ENGCLLDYLRERKGKLPKALLLSMCQDICEGMAYLEKSCYIHRDLAARNCLVSSACVVKISDFGM 410

Human   415 TRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVV 479
            .||||||||:||.|||||:||||||||.|||||||||||||||||||||||||||||||||||||
  Rat   411 ARYVLDDEYISSSGAKFPVKWSPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVV 475

Human   480 EAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW 530
            ||||:|||||||||||||||.||||||||.|:|||||||||:.:.||||||
  Rat   476 EAISKGFRLYRPHLAPMSIYGVMYSCWHESPKGRPTFAELLQVLAEIAETW 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TXK	XP_024309968.1	SH3_TXK	88..142	CDD:212840	47/53 (89%)
		SH2_Tec_Txk	146..251	CDD:198261	85/104 (82%)
		PTKc_Tec_like	269..524	CDD:173637	223/254 (88%)
Txk	NP_001019426.1	SH3_TXK	84..138	CDD:212840	47/53 (89%)
		SH2_Tec_Txk	142..247	CDD:198261	85/104 (82%)
		PKc_like	265..520	CDD:304357	223/254 (88%)
		Pkinase_Tyr	270..519	CDD:285015	218/248 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696400
Domainoid	1	1.000	456	1.000	Domainoid score	I8745
eggNOG	1	0.900	-	-		E2759_KOG0197
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2497
Inparanoid	1	1.050	911	1.000	Inparanoid score	I6271
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52659
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto144430
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X592
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270