DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TXK and txk

DIOPT Version :9

Sequence 1:	XP_024309968.1	Gene:	TXK / 7294	HGNCID:	12434	Length:	530	Species:	Homo sapiens
Sequence 2:	XP_003201292.4	Gene:	txk / 100534735	ZFINID:	ZDB-GENE-130530-553	Length:	509	Species:	Danio rerio

Alignment Length:	473	Identity:	275/473 - (58%)
Similarity:	360/473 - (76%)	Gaps:	5/473 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    56 LSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNP 120
            ::|:...:....|.|::| ||..||.:.....::|.|:|||..||..:|.|.|.|.|:||.|.:.
Zfish    37 MNNRYPGSVYTAQISQKK-LPRSPPDDDDNGVMKVVAMYDFTARESSDLTLHRGETYIILHKQDQ 100

Human   121 HWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLG 185
            .||:|:||.||:|.||||||||.  ..:|..:||.:||.|.:||||||||.|:|.|:||.|....
Zfish   101 LWWRAKDRHGNKGFIPSNYVTET--GTIEANDWYCKNINRAEAEHLLRQEGKDGGFVVRSSSQPS 163

Human   186 SYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVG 250
            :||:||:  ...|.:..::|||||:.|..::|:||.|.|.||||||.||::|||||:.|||||:|
Zfish   164 TYTVSVY--THCSGKGEVRHYQIKRTDEDKFYLAENHVFISIPELINYHKYNAAGLVARLRYPIG 226

Human   251 LMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFI 315
            ..|.|.|||||||.:|.||:||||.|:||:||||||||.||:||:..:||||.|.||:|:|:|||
Zfish   227 PKGKCQPATAGFSSDKMEINPSELTFMKELGSGQFGVVRLGKWRAQHKVAIKTIREGAMNEDDFI 291

Human   316 EEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEG 380
            ||||:|.:|.|.|||||||||:.::|:.||||||||||||::||::...|.:..:|.:|||:|||
Zfish   292 EEAKIMTRLCHPKLVQLYGVCVTQRPICIVTEFMENGCLLHFLRQHSKTLGRSQMLCMCQDVCEG 356

Human   381 MEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 445
            |||||.|.:||||||||||||:...:||:.||||||||||::|.||.|::||:|||||||..|||
Zfish   357 MEYLEHNQFIHRDLAARNCLVNERNVVKVCDFGMTRYVLDNQYTSSMGSRFPVKWSPPEVLHFNK 421

Human   446 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKP 510
            :|:|||||||||||||||:|||.||:|::|::|||.:::|.||||||||...||.:||.||||:|
Zfish   422 FSNKSDVWSFGVLMWEVFSEGKTPFDNRTNVEVVEEVTQGSRLYRPHLATPHIYNIMYRCWHERP 486

Human   511 EGRPTFAELLRAVTEIAE 528
            .|||.|:|||:...:|.|
Zfish   487 HGRPAFSELLQDFRQITE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TXK	XP_024309968.1	SH3_TXK	88..142	CDD:212840	29/53 (55%)
		SH2_Tec_Txk	146..251	CDD:198261	54/104 (52%)
		PTKc_Tec_like	269..524	CDD:173637	168/254 (66%)
txk	XP_003201292.4	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I5582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2497
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	7	7.520