DRSC/TRiP Functional Genomics Resources

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Protein Alignment CCR2 and PK1-R

DIOPT Version :9

Sequence 1:NP_001116513.2 Gene:CCR2 / 729230 HGNCID:1603 Length:374 Species:Homo sapiens
Sequence 2:NP_001014620.1 Gene:PK1-R / 41713 FlyBaseID:FBgn0038201 Length:430 Species:Drosophila melanogaster


Alignment Length:359 Identity:79/359 - (22%)
Similarity:131/359 - (36%) Gaps:108/359 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    48 LYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLIT-LP-----LWAHSAANEW 106
            :|||:||.|.|||:...:::...:.:...|:.||.:|||||.|.|:: :|     :|   :...:
  Fly    26 VYSLIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVPQEVSYIW---SKYPY 87

Human   107 VFGNAMCKLFTGLY-HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVF 170
            |||..:| :..||. .......:..|...|::||:||.|.........::..:...|:.|::|:.
  Fly    88 VFGEYIC-IGRGLLAETSANATVLTITAFTVERYIAICHPFLGQAMSKLSRAIRIIVLVWIMAIV 151

Human   171 ASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILG------------------LVLPLLI 217
            .::|.......:....|..||            |:|.|:.                  |||.|||
  Fly   152 TAIPQAAQFGIEHYSGVEQCG------------IVRVIVKHSFQLSTFIFFLAPMSIILVLYLLI 204

Human   218 MVICY-----------------------------------------------------SGILKTL 229
            .|..|                                                     ||...:.
  Fly   205 GVHLYRSTLVEGPASVARRQQLKSVPSDTILYRYGGSGTAMSFNGGGSGAGTAGLMGGSGAQLSS 269

Human   230 LRCR-NEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQ-------A 286
            :|.| |.....|.:|::..:::.:||.|.|::...|:..:      :........||       .
  Fly   270 VRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIAIY------APARGAKLRDQHEFVYTVM 328

Human   287 TQVTETLGMTHCCINPIIYAFVGEKFRSLFHIAL 320
            |.|:..|.....||||::|..:..|||..|...|
  Fly   329 TYVSGVLYYLSTCINPLLYNIMSHKFREAFKAVL 362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CCR2NP_001116513.2 7tmA_CCR5_CCR2 43..316 CDD:320312 77/353 (22%)
TM helix 1 43..70 CDD:320312 9/21 (43%)
TM helix 2 77..102 CDD:320312 12/30 (40%)
TM helix 3 113..143 CDD:320312 8/30 (27%)
TM helix 4 155..177 CDD:320312 4/21 (19%)
TM helix 5 199..228 CDD:320312 13/99 (13%)
TM helix 6 236..266 CDD:320312 7/29 (24%)
TM helix 7 284..309 CDD:320312 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..374
PK1-RNP_001014620.1 7tmA_capaR 21..358 CDD:320262 77/353 (22%)
TM helix 1 21..48 CDD:320262 9/21 (43%)
TM helix 2 55..81 CDD:320262 11/25 (44%)
TM helix 3 94..124 CDD:320262 8/30 (27%)
TM helix 4 136..158 CDD:320262 4/21 (19%)
TM helix 5 178..207 CDD:320262 6/28 (21%)
TM helix 6 277..307 CDD:320262 7/29 (24%)
TM helix 7 326..351 CDD:320262 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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