Protein Alignment TWIST1 and Fer2

DIOPT Version :9

• Sequence 1: NP_000465.1
• Gene: TWIST1 / 7291
• HGNCID: 12428
• Length: 202
• Species: Homo sapiens
• Sequence 2: NP_001287359.1
• Gene: Fer2 / 41961
• FlyBaseID: FBgn0038402
• Length: 283
• Species: Drosophila melanogaster
• Alignment Length: 220
• Identity: 75/220 - (34%)
• Similarity: 90/220 - (40%)
• Gaps: 73/220 - (33%)

Human     6 SSSPVSPA-----DDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGG------- 58
            ||.|:|..     ||.|.|        ..||....|:.:.......|||:|.||.:.|
  Fly    11 SSPPISHLPFHNFDDDLIN--------DLPSCIYAGQHQGGGATGGGGGSGGGGGSSGLRLSSNN 67

Human    59 ------------------------GV--GGGDEP---GSPAQGKRGKKSAGCGGGGGA--GGGGG 92
                                    ||  .||..|   .||:....|   .|||..|.|  ||.||
  Fly    68 LRHIQQHYMQHSGENLLDSSTNPMGVHNSGGGAPLMCNSPSASSSG---GGCGNAGSATPGGAGG 129

Human    93 SSSGGGS-----PQSYEELQTQRVMANVRERQRTQ----------SLNEAFAALRKIIPTLPSDK 142
            .:.|.||     ..||   :.||..||||||:|.|          |:|.||..||..:||.|.:|
  Fly   130 PNPGYGSVGAATASSY---KMQRQAANVRERKRIQRSAPTGYTKCSINSAFDELRVHVPTFPYEK 191

Human   143 -LSKIQTLKLAARYIDFLYQVLQSD 166
             ||||.||:||..||..|.:|||:|
  Fly   192 RLSKIDTLRLAIAYISLLREVLQTD 216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TWIST1	NP_000465.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		40/146 (27%)
		HLH	109..159	CDD:278439	30/60 (50%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	161..191		4/6 (67%)
Fer2	NP_001287359.1	HLH	148..210	CDD:278439	30/61 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I5283
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960