Protein Alignment TWIST1 and twi

DIOPT Version :10

• Sequence 1: NP_000465.1
• Gene: TWIST1 / 7291
• HGNCID: 12428
• Length: 202
• Species: Homo sapiens
• Sequence 2: NP_523816.2
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Alignment Length: 281
• Identity: 85/281 - (30%)
• Similarity: 117/281 - (41%)
• Gaps: 84/281 - (29%)

Human     2 MQDVSSSPVS------------------PADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGG 48
            :|...:||.|                  |..::.....::..:|||..........:::.|.:..
  Fly   211 VQSTCTSPQSHFDFPDEELPEHKAQVFLPLYNNQQQQSQQLQQQQPHQQSHAQMHFQNAYRQSFE 275

Human    49 GAGPGGAAGGGVGGGDEP-----------GSPAQGKRGKKSAGCGGGGGAGGG--GGSSSGG--- 97
            |..|..:..|......:.           .|.:....|..|..|....|:.|.  .||.:||
  Fly   276 GYEPANSLNGSAYSSSDRDDMEYARHNALSSVSDLNGGVMSPACLADDGSAGSLLDGSDAGGKAF 340

Human    98 -----------GSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKL 151
                       ...:..:|...|||||||||||||||||:||.:|::||||||||||||||||||
  Fly   341 RKPRRRLKRKPSKTEETDEFSNQRVMANVRERQRTQSLNDAFKSLQQIIPTLPSDKLSKIQTLKL 405

Human   152 AARYIDFLYQVLQSDE------LDSKMASCSY-----------------------------VAHE 181
            |.||||||.::|.|.:      |:::.:..:|                             :..|
  Fly   406 ATRYIDFLCRMLSSSDISLLKALEAQGSPSAYGSASSLLSAAANGAEADLKCLRKANGAPIIPPE 470

Human   182 RLSYAFSVWRMEGAWSMSASH 202
            :|||.|.||||||    .|.|
  Fly   471 KLSYLFGVWRMEG----DAQH 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TWIST1	NP_000465.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		22/147 (15%)
		bHLH_TS_TWIST1	98..174	CDD:381418	49/81 (60%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	161..191		10/64 (16%)
twi	NP_523816.2	bHLH_TS_TWIST	363..421	CDD:381470	47/57 (82%)