DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TWIST1 and CG33557

DIOPT Version :9

Sequence 1:	NP_000465.1	Gene:	TWIST1 / 7291	HGNCID:	12428	Length:	202	Species:	Homo sapiens
Sequence 2:	NP_001014730.1	Gene:	CG33557 / 3346145	FlyBaseID:	FBgn0053557	Length:	150	Species:	Drosophila melanogaster

Alignment Length:	122	Identity:	38/122 - (31%)
Similarity:	59/122 - (48%)	Gaps:	22/122 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    78 SAGCGGGGGAGG-------GGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKII 135
            |:|...|.||..       |..::.||...|.....:..|...|.|||.||.::|.|:.|||.:|
  Fly    24 SSGSASGSGAAADSEDSQIGQEANPGGQENQGNHRRRPPRQKINARERYRTFNVNSAYEALRNLI 88

Human   136 PTLPSD-KLSKIQTLKLAARYIDFLYQVL--------------QSDELDSKMASCSY 177
            ||.|.: |||||:.::||:.||..|...|              :|:.:..:::.|::
  Fly    89 PTEPMNRKLSKIEIIRLASSYITHLSSTLETGTECQPCLLHKYESEGITRRISICTF 145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TWIST1	NP_000465.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		9/33 (27%)
		HLH	109..159	CDD:278439	25/50 (50%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	161..191		3/31 (10%)
CG33557	NP_001014730.1	HLH	67..119	CDD:197674	26/51 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149594
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840