Protein Alignment TWIST1 and ase

DIOPT Version :10

• Sequence 1: NP_000465.1
• Gene: TWIST1 / 7291
• HGNCID: 12428
• Length: 202
• Species: Homo sapiens
• Sequence 2: NP_476694.1
• Gene: ase / 30985
• FlyBaseID: FBgn0000137
• Length: 486
• Species: Drosophila melanogaster
• Alignment Length: 177
• Identity: 40/177 - (22%)
• Similarity: 66/177 - (37%)
• Gaps: 45/177 - (25%)

Human     5 VSSSPVSPADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGGVGGGDEPGSP 69
            :||....|..:|...:......||........:|.:::::.|             |....:.|:.
  Fly    84 ISSQRKRPLGESQKQNRHNQQNQQLSKTSVPAKKCKTNKKLA-------------VERPPKAGTI 135

Human    70 AQGKRGKKSAGCGGGGGAGGGGGSSSGGGSPQSYEELQTQRVMA--NVRERQRTQSLNEAFAALR 132
            :...:.:.....|..|..|                 |...:.:|  |.|||.|.:.:|..||.||
  Fly   136 SHPHKSQSDQSFGTPGRKG-----------------LPLPQAVARRNARERNRVKQVNNGFALLR 183

Human   133 KIIPTLPSD-------------KLSKIQTLKLAARYIDFLYQVLQSD 166
            :.||...|:             ||||::||::|..||..|.::|..|
  Fly   184 EKIPEEVSEAFEAQGAGRGASKKLSKVETLRMAVEYIRSLEKLLGFD 230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TWIST1	NP_000465.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		13/99 (13%)
		bHLH_TS_TWIST1	98..174	CDD:381418	27/84 (32%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	161..191		2/6 (33%)
ase	NP_476694.1	bHLH_TS_dAS-C_like	170..227	CDD:381587	19/56 (34%)