DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TULP3 and Tusp

DIOPT Version :10

Sequence 1:NP_001153880.1 Gene:TULP3 / 7289 HGNCID:12425 Length:501 Species:Homo sapiens
Sequence 2:NP_001263014.1 Gene:Tusp / 43317 FlyBaseID:FBgn0039530 Length:1433 Species:Drosophila melanogaster


Alignment Length:443 Identity:105/443 - (23%)
Similarity:153/443 - (34%) Gaps:142/443 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    52 NPEARLRRAKPRAS---DEQTPLVNCHTPHSNVILHGIDGPAAVLKPDEVHAPSVSSSVVEE--- 110
            :|.:..:|.:|.||   ||.|.:|....|..       :.||...||    ||.....|:..   
  Fly  1067 SPSSACKRCQPSASSVLDEITAVVPAVEPAK-------ESPAVQAKP----APKKRFDVITSFTD 1120

Human   111 -------------DAENTVDTASKPGLQERLQKHDISESVNFDE------------ETDGISQSA 150
                         .::.|..|.:...|..|.|.:..|......|            :.:|.|.::
  Fly  1121 SPLFTRKHRFGIGRSKETAGTENSTPLLGRKQDNGFSFVKQLSEVRWRRKEQPAQAQVNGSSNAS 1185

Human   151 CLER---PNSASSQNSTDTGTSGSATAA--------QPADNLLGDIDDLEDFVYSP--APQGVTV 202
            .|||   |....:...|...|...|.|:        ...:|::..:.||::...:|  .||    
  Fly  1186 TLERQPQPEITGAACGTVEATPVEAKASVSLHTQALTTLENIISRLRDLDEGRLTPPSTPQ---- 1246

Human   203 RCRIIRDKRGMDRGLFPTYYMYLEKEENQKIF----------LLAARKRKKSKTANYLISIDPVD 257
              |:.|..        |......:|.:.|:..          ||..|:|||...      |:..|
  Fly  1247 --RLPRSS--------PASPAASKKNKRQQSNSPIRHILNSPLLNRRQRKKQSI------IESSD 1295

Human   258 LSREGESYVGK-LRSNLMGT-----KFTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFK 316
              .||....|. ..||..|.     ....:.:             |..||:|.....|.|     
  Fly  1296 --DEGNQTNGSGEESNNAGNGKQYRDLETFQK-------------AQLRQKLKRGKIEPN----- 1340

Human   317 GPRKMSVIIPGMTLNHKQIPYQPQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRG 381
                      |........|.:.:                  ..:|||||:||..:|.|.|:|.|
  Fly  1341 ----------GSASCANPAPVRRE------------------FVMHNKAPMWNEMSQVYQLDFGG 1377

Human   382 RVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSS 434
            ||||.|.|||||..:...   ||||||:..:.:|||:.||..|:|||.:.|::
  Fly  1378 RVTQESAKNFQIEFRGKQ---VMQFGRIDGNAYTLDFQYPFSALQAFAVALAN 1427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TULP3NP_001153880.1 Required for association with the IFT complex A (IFT-A) 23..68 6/18 (33%)
Tub_N 31..171 CDD:465092 32/152 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..177 19/114 (17%)
Tub 193..436 CDD:460094 68/260 (26%)
TuspNP_001263014.1 WD40 <81..221 CDD:441893
WD40 repeat 91..126 CDD:293791
WD40 repeat 132..168 CDD:293791
WD40 repeat 173..208 CDD:293791
WD40 repeat 216..263 CDD:293791
WD40 repeat 270..333 CDD:293791
Tub <1249..1426 CDD:460094 63/241 (26%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.