Protein Alignment TULP3 and ktub

DIOPT Version :9

• Sequence 1: NP_001153880.1
• Gene: TULP3 / 7289
• HGNCID: 12425
• Length: 501
• Species: Homo sapiens
• Sequence 2: NP_611549.2
• Gene: ktub / 37400
• FlyBaseID: FBgn0015721
• Length: 469
• Species: Drosophila melanogaster
• Alignment Length: 485
• Identity: 196/485 - (40%)
• Similarity: 273/485 - (56%)
• Gaps: 100/485 - (20%)

Human    24 RQAKLDYQRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNCHTPHSNV-----IL 83
            |..|::.||.|:|...|:||..|.|||             |||.|     .:.|.|.:     .|
  Fly     7 RNQKMEQQRQLMEAYIRQKRASPGMVQ-------------ASDLQ-----INRPMSGMRSNSREL 53

Human    84 HGIDGPAAVL----KPDEV-------------------HAPSVSS-------------------- 105
            |..|||...:    .||::                   |:.::.|
  Fly    54 HAYDGPMQFISSPQNPDQILTNGSPGGINPVAMNTSRNHSNNMRSLSTINQEGKWSYTPRKADLI 118

Human   106 ----------------SVVEEDAENTVDTASKPGLQE-RLQKHDISESVNFDEETDGISQSACLE 153
                            :|:|:..::...:|:....|: |.::|..|::::.|:.|:.....|...
  Fly   119 EEISSHELEDEESSPVTVIEQHQQSASHSANSTQSQKPRARQHSFSDNLDEDDYTNRNVAGAAPV 183

Human   154 RPNSASS---QNSTDTGTS---GSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRG 212
            ||...:|   :::|..|:|   |:.|..:...:::|:||   .||..||||||..:|||.||::|
  Fly   184 RPAGMASSPYKDATLDGSSNGTGNGTGGESEGDVIGNID---QFVMQPAPQGVLYKCRITRDRKG 245

Human   213 MDRGLFPTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLMGTK 277
            |||||||.||::||::..:|||||..||||||||:||::|.||.||||..:.:.||||||:.||.
  Fly   246 MDRGLFPIYYLHLERDYGKKIFLLGGRKRKKSKTSNYIVSCDPTDLSRNADGFCGKLRSNVFGTS 310

Human   278 FTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQN- 341
            |||:|.|       ........|.:||.|.|:||:|||||||.|:||:||||.:.:::.....:
  Fly   311 FTVFDNG-------NKESTESPRLDLAVIIYDTNILGFKGPRNMTVILPGMTEDDQRVKISSADP 368

Human   342 NHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQF 406
            ....:|..|:.:.|:|:||||||.||||.:||||||||.||||||||||||:||.:||:||||||
  Fly   369 KQQGILDLWKMKNMDNIVELHNKTPVWNDETQSYVLNFHGRVTQASVKNFQLVHDSDPEYIVMQF 433

Human   407 GRVADDVFTLDYNYPLCAVQAFGIGLSSFD 436
            ||.::||||:||.|||||:|||.|.|||||
  Fly   434 GRTSEDVFTMDYRYPLCAMQAFAIALSSFD 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TULP3	NP_001153880.1	Required for association with the IFT complex A (IFT-A)	23..68		16/43 (37%)
		Tub_N	31..169	CDD:292938	41/205 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..177		19/118 (16%)
		Tub	195..435	CDD:279506	142/240 (59%)
ktub	NP_611549.2	Tub	228..462	CDD:279506	142/240 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1121
eggNOG	1	0.900	-	-		E1_KOG2502
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20711
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2142
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1445357at2759
OrthoFinder	1	1.000	-	-		FOG0000431
OrthoInspector	1	1.000	-	-		otm41820
orthoMCL	1	0.900	-	-		OOG6_101683
Panther	1	1.100	-	-	O	PTHR16517
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2866
SonicParanoid	1	1.000	-	-		X288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.860