Protein Alignment ZBTB8B and eor-1

DIOPT Version :10

• Sequence 1: NP_001139192.1
• Gene: ZBTB8B / 728116
• HGNCID: 37057
• Length: 495
• Species: Homo sapiens
• Sequence 2: NP_001367921.1
• Gene: eor-1 / 177249
• WormBaseID: WBGene00001324
• Length: 909
• Species: Caenorhabditis elegans
• Alignment Length: 648
• Identity: 133/648 - (20%)
• Similarity: 207/648 - (31%)
• Gaps: 229/648 - (35%)

Human    10 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSD 74
            |...|..|||...|||..|:|:.:.|.||||||.|:|.||.| :..|.:.:....|  ::..:..
 Worm    28 LFQRLQYQRKTGRFCDVEIVVQNKSFAAHRNILAAHSPYFDA-IFKYCKITKEQLT--INSKSPQ 89

Human    75 AFSIILDFLYSGKLDLCGENVIEVMSAASYLQMNDVVNFCKTYIRSSLDICRKMEKEAAVAAAVA 139
            .|.:.|:::|||.:.:...:|.|::..|:...:..:..:|..|:...||        ||...::.
 Worm    90 VFELFLNYMYSGTVIIDRSSVSELLRFANNFLIVKLKVYCAAYLDRYLD--------AANCLSIR 146

Human   140 AAAAA--AAAAAAAAAHQVDSESPSSGREG------TSCGTKSLVSSPAEGEKSVECLRESPCGD 196
            ..|..  ......:|....||.......|.      |......|:..|    |.|:|:
 Worm   147 TLAQRYNLPGLVKSATDYFDSNLNRCLLESRDIIGYTYTQLTRLIGDP----KYVDCI------- 200

Human   197 CGDCHPLELVVRDSLGGGSADSNLSTPPKRIEPKVEFDADEVEVDVGEQLQQYAAPLN------- 254
            ..|.: |:|:||   ..|...|......:.:....||  .||..|..|.|..|:..|:
 Worm   201 TSDTY-LKLIVR---WVGEEVSKREEIFRLLLESCEF--REVSADTLEFLLDYSPLLSKSQKSRF 259

Human   255 -LAHVEEA-----------LPS--GQAVDLAYSNYHVKQFLEALLRNSAAPSKDDADHHFSRSLE 305
             |.||.|.           |.|  .:.|||... :...||.:.:..:|  .|::|.|.:.:   :
 Worm   260 LLLHVMETNNMLMEKYSTQLSSLRQKIVDLPIL-HDPSQFEDDIYDSS--DSEEDPDDYIA---D 318

Human   306 GRPEGAGVA-----------------------------------------MSSMMDVQADWYGED 329
            |.|..|.|.                                         :::..:....|..||
 Worm   319 GHPTSAQVVEYGNDVNNRLKMKIAFQPGNEKKRLKRPKGMKKHHLHPIPPINATENESIPWIDED 383

Human   330 SGDVLVVPIKLH-----------------------------KCPFCPYTAKQKGILKR------- 358
            ..|.:.....|.                             .|.||......:.:|::
 Worm   384 EIDGVYATCSLEGCHTYGPVDNLDPDDCEDEEDQPDENGPSTCIFCGLRTANEELLEKHKARHHN 448

Human   359 ----------------------HIRSHTGERPYPCETC------------------GKRF----- 378
                                  |...|..|.||.||||                  .:||
 Worm   449 RNTYYMCHLCEFETNWSKQFYLHCAEHWTEIPYRCETCPFTSNEIQEFLTHRLQHTDERFFKCGE 513

Human   379 ------TRQE---HLRSHALSVHRSNRPIICKGCRRTFTSH-------LSQGLRRFGLCDSCTCV 427
                  ||.:   |.|.|::   ..:|.:.|:.|.|.|..|       .|....|..:|:.|...
 Worm   514 CAWKGRTRSQLFAHERMHSV---LDDRSLHCEECGRGFQQHSTLDHHVASHNDPRPYICEDCGFA 575

Human   428 TDTPDDDDDLMPINLSLVEASSESQEKSDTDNDWPIYVESGEENDPAGDD--SDDKPQIQPNL 488
            |.|.|        :|||       ..:..|.:::..::        ||.|  |..|.|:..:|
 Worm   576 TKTAD--------HLSL-------HRRQHTGDNFSCHI--------AGCDYSSTKKSQLAAHL 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZBTB8B	NP_001139192.1	BTB_POZ_ZBTB8B	6..118	CDD:349639	33/107 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..178		5/26 (19%)
		zf-H2C2_5	341..365	CDD:404746	6/81 (7%)
		C2H2 Zn finger	343..363	CDD:275368	5/48 (10%)
		zf-H2C2_2	356..380	CDD:463886	12/81 (15%)
		C2H2 Zn finger	371..392	CDD:275368	11/52 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..495		8/45 (18%)
eor-1	NP_001367921.1	PHA03098	34..>229	CDD:222983	54/220 (25%)
		BTB_POZ_ZBTB_KLHL-like	41..118	CDD:349497	26/79 (33%)
		C2H2 Zn finger	455..475	CDD:275368	1/19 (5%)
		C2H2 Zn finger	483..503	CDD:275368	4/19 (21%)
		C2H2 Zn finger	511..531	CDD:275368	4/19 (21%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		C2H2 Zn finger	569..589	CDD:275368	8/34 (24%)
		C2H2 Zn finger	601..618	CDD:275368	5/15 (33%)
		C2H2 Zn finger	626..646	CDD:275368
		zf-H2C2_2	638..663	CDD:463886
		zf-H2C2_5	652..676	CDD:404746
		C2H2 Zn finger	654..674	CDD:275368