Protein Alignment TUBB2A and alphaTub85E

DIOPT Version :10

• Sequence 1: NP_001060.1
• Gene: TUBB2A / 7280
• HGNCID: 12412
• Length: 445
• Species: Homo sapiens
• Sequence 2: NP_524297.1
• Gene: alphaTub85E / 41183
• FlyBaseID: FBgn0003886
• Length: 449
• Species: Drosophila melanogaster
• Alignment Length: 450
• Identity: 181/450 - (40%)
• Similarity: 269/450 - (59%)
• Gaps: 14/450 - (3%)

Human     1 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQL----ERINVYYNEAAGNKYVP 61
            |||.:.:..||.|.|||...||:...||||.|.|  |..||..:    :..:.:::|....|:||
  Fly     1 MRECISVHIGQAGVQIGNACWELYCLEHGIQPDG--HMPSDKTVGGGDDSFSTFFSETGAGKHVP 63

Human    62 RAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESES 126
            ||:.|||||..:|.||:|.:.|:|.|:..:.|:..|.||:|:||||.|.|:||.|||.:||.::.
  Fly    64 RAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDVVLDRIRKLADQ 128

Human   127 CDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQ 191
            |..||||.:.||.|||||||..:||:.::..:|..:....||:.|:|:||..||||||:.|:.|.
  Fly   129 CTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHT 193

Human   192 LVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVN 256
            .:|::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:...|
  Fly   194 TLEHSDCAFMVDNEAIYDICRRNLDIERPTYMNLNRLIGQIVSSITASLRFDGALNVDLTEFQTN 258

Human   257 MVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRM 321
            :||:||:||.:..:||:.|.....:..|||.|:|...|:..|.|..||||.|:|:....::||.:
  Fly   259 LVPYPRIHFPLATYAPVISVEKAYHEQLTVAEITNACFEPANQMVKCDPRRGKYMACCMLYRGDV 323

Human   322 SMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPP--------RGLKMSATFIGNSTAIQELF 378
            ..|:|:..:..::.|.|..||:|.|...|..:...||        ..::.:...:.|:|||.|.:
  Fly   324 VPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAW 388

Human   379 KRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEE 438
            .|:..:|..|:.::||:|||.||||:|.||.||..::..|..:|::....:..|.||.||
  Fly   389 ARLDHKFDLMYAKRAFVHWYVGEGMEEGEFAEAREDLAALEKDYEEVGIDSTTELGEDEE 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBB2A	NP_001060.1	PLN00220	1..430	CDD:215107	176/440 (40%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..445		5/16 (31%)
alphaTub85E	NP_524297.1	PTZ00335	1..448	CDD:185562	179/448 (40%)