Protein Alignment TUBB2A and alphaTub67C

DIOPT Version :10

• Sequence 1: NP_001060.1
• Gene: TUBB2A / 7280
• HGNCID: 12412
• Length: 445
• Species: Homo sapiens
• Sequence 2: NP_524009.2
• Gene: alphaTub67C / 39130
• FlyBaseID: FBgn0087040
• Length: 462
• Species: Drosophila melanogaster
• Alignment Length: 467
• Identity: 185/467 - (39%)
• Similarity: 268/467 - (57%)
• Gaps: 33/467 - (7%)

Human     1 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSY--------HGDS-----DLQLERINVYYN 52
            |||:|.||.||||.|||...||:...||||:..||.        .|.|     |........::.
  Fly     1 MREVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFT 65

Human    53 EAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVL 117
            |....|.|||:|.|||||..:|.||:|...:::.|:..:.|:..|.||:|:|.|:.|.|::|.|.
  Fly    66 ETGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVT 130

Human   118 DVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEP 182
            ..::|.:|.||.||||.:.||||||||||..:||:.::..:|..:....|:|.||||||..||||
  Fly   131 SRLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEP 195

Human   183 YNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLN 247
            |||.|:.|..::::|..:.:||||:||||..:|.:..|.|.:||.|::..:|..|..|||.|.:|
  Fly   196 YNALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMN 260

Human   248 ADLRKLAVNMVPFPRLHFFMPGFAPLTS--RGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRY 310
            .||.:...|:|||||:||.:..:|||.|  |.:.:..|:|.  ||...|:|.|||..||||.|::
  Fly   261 VDLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITT--LTNACFESSNMMVKCDPRAGKF 323

Human   311 LTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAV-----CDIPPRGL---KMSATF 367
            :....::||.:..|:|:..:..:::|....||:|.|...|..:     ..:|...|   ..:...
  Fly   324 MACCMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCM 388

Human   368 IGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADE 432
            :.|:|||...|..:|.:|..||:::||:|||.||||:|.|||||..|:..|..::        :|
  Fly   389 LSNTTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDF--------EE 445

Human   433 QGEFEEEEGEDE 444
            .|....|||.||
  Fly   446 VGLDNAEEGGDE 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBB2A	NP_001060.1	PLN00220	1..430	CDD:215107	178/451 (39%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..445		7/23 (30%)
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	177/453 (39%)