DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GOLGA6L6 and FUN12

DIOPT Version :9

Sequence 1:	NP_001138476.2	Gene:	GOLGA6L6 / 727832	HGNCID:	37225	Length:	724	Species:	Homo sapiens
Sequence 2:	NP_009365.1	Gene:	FUN12 / 851196	SGDID:	S000000033	Length:	1002	Species:	Saccharomyces cerevisiae

Alignment Length:	452	Identity:	109/452 - (24%)
Similarity:	214/452 - (47%)	Gaps:	102/452 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   204 DEELKEKNAELQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK 268
            |||.:|..|:.:|    :.:..:                    |..:..|.||...:| .|.||:
Yeast    14 DEEFEEDAAQNEE----ISATPT--------------------PNPESSAGADDTSRE-ASASAE 53

Human   269 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 333
             .|:..|.:..:.|.|.::    :||:|:  .||| ::.:..::.::||.:|::||
Yeast    54 -GAEAIEGDFMSTLKQSKK----KQEKKV--IEEK-KDGKPILKSKKEKEKEKKEK--------- 101

Human   334 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 398
            ||::|          ||:..|::.:...:| ||.:||.::  ..||...::...::.:|.:.:..
Yeast   102 EKQKK----------KEQAARKKAQQQAQK-EKNKELNKQ--NVEKAAAEKAAAEKSQKSKGESD 153

Human   399 RQEQEAKMWRQEEKIREQEEKIREQ-EKKMWRQEEKIHEQEKI-REEEKRQEQEEMWRQEEKIRE 461
            :....||  :..:|:......:|.| |.|     :::.||||: ||||:|.|:||    ||::..
Yeast   154 KPSASAK--KPAKKVPAGLAALRRQLELK-----KQLEEQEKLEREEEERLEKEE----EERLAN 207

Human   462 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 526
            :       |||.|:.:..:|::||..|::   |:.|.|:..:::|   :|:|:.|:.   |....
Yeast   208 E-------EKMKEEAKAAKKEKEKAKREK---RKAEGKLLTRKQK---EEKKLLERR---RAALL 256

Human   527 MHEQEKIWEEEKRQEQEDK----MWRQEEKIREQEEKVWRQEEKIREQEEKRQE--QEEKMWKQE 585
            .....|:....|:..:|:|    ::.:::|...||    ...|.|:...:|..|  .::::.:.|
Yeast   257 SSGNVKVAGLAKKDGEENKPKKVVYSKKKKRTTQE----NASEAIKSDSKKDSEVVPDDELKESE 317

Human   586 EKIREQEEKIR---EQEEKIREQEEK---IREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 641
            :.:.:..|.:.   :.||...|:.::   ..|.|:..|.:||:.||:||:  |:||:....|
Yeast   318 DVLIDDWENLALGDDDEEGTNEETQESTASHENEDQNQGEEEEEGEEEEE--EEEERAHVHE 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GOLGA6L6	NP_001138476.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..342		8/27 (30%)
		TPH	367..713	CDD:290579	71/289 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..454		22/81 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..548		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..724		22/89 (25%)
FUN12	NP_009365.1	InfB	400..964	CDD:392272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000