DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTK and Mps1

DIOPT Version :9

Sequence 1:	NP_003309.2	Gene:	TTK / 7272	HGNCID:	12401	Length:	857	Species:	Homo sapiens
Sequence 2:	NP_001262677.1	Gene:	Mps1 / 42126	FlyBaseID:	FBgn0000063	Length:	672	Species:	Drosophila melanogaster

Alignment Length:	719	Identity:	203/719 - (28%)
Similarity:	291/719 - (40%)	Gaps:	221/719 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   115 RFAELKAIQEPDDARDYF------QMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERG 173
            |..::.|:....|:.|.|      :.|.|..:|...|    |.|::         |...|..|..
  Fly     8 RTKDMMALGLDSDSEDDFNTPYRPRQAAAGERKQQPV----ASFQV---------QTRGKENEPH 59

Human   174 AVPLEMLEIALRNLNLQKKQLLSEEEKKN-------LSASTVLTAQESFSGS------------- 218
            .:|:.||...:..|.:.......|:.|.|       |:.|.||:..:..:.|
  Fly    60 PLPINMLPRRVSELTMMDSDSDEEDIKSNHNLNCAILNDSFVLSPSQELTNSNSNITTRRTPSAA 124

Human   219 -----------LGHLQNRNNSCDSRGQ---------------TTKARFLYGENMPPQDAEIGYRN 257
                       ||...:...:|.|:|.               |.:|.....|..|.|:.|...||
  Fly   125 PLKQSDSNLSFLGRFNDMGINCSSQGSPVANSEKQVAKKTAPTLQAAPSATERRPLQETETPLRN 189

Human   258 SLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSC 322
            .|..|:|||               ||.|..|               .:.|.:   ||..:|....
  Fly   190 ELPSTSKTK---------------PDADFIT---------------PQVRTI---GSTLAGKSRS 221

Human   323 ELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQW 387
            .:.|....|...|:.|:.....:.  :.:|||:.      ||...:.|:     |::||..:|..
  Fly   222 AVSNDFRAQKVLFQTPMTVSRAAP--VASDSISF------SLCDTITES-----PDIPEPPKKAE 273

Human   388 QSKRKSECINQNPAASS-NHWQIPELARKVNTEQKHTTFEQPVFSVS-KQSPPISTSKWFDPKSI 450
            ..|      :|:|:..| :|                      ||..| |.:.|..... .:||.:
  Fly   274 PPK------SQHPSKKSLDH----------------------VFRESDKDNVPDKVDN-VEPKEL 309

Human   451 CKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSAN 515
            ...|:                         ::.|..||                      |...:
  Fly   310 VSIPA-------------------------VAVPPEQP----------------------SHKTS 327

Human   516 ECISVKGRIYSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ 579
            ..:.:|...|:|.|::|.||||.||.. .::....:|:|.|:| :||.|.:..|.||...|.|||
  Fly   328 NILKIKNHEYTIDKKLGCGGSSSVFLARRSDSGNEFALKVVDL-QADPQVVQGYLNETKLLAKLQ 391

Human   580 QHSDKIIRLYDYEIT--DQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKN------------ 630
            .:. .::.||||::.  :..:|||||.|:.|||..|           :||..|
  Fly   392 GNV-CVVALYDYQLVREESKLYMVMEKGDCDLNKIL-----------QSYTTNLPLYSLMNILYQ 444

Human   631 MLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 695
            ||:||:.|||||::||||||||||:|.|.|||||||||:.:..|:||::|.||.||.||:.|||:
  Fly   445 MLQAVNYIHQHGVIHSDLKPANFLMVSGRLKLIDFGIASNIAVDSTSIIKFSQAGTFNYISPEAL 509

Human   696 KDMSSS----RENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEF 756
            .|.|:.    |...:.|.|||.||||||||||||.:.|.||||..|.|..:|:.||..|...||:
  Fly   510 TDTSTGNSPMRRADQPKIKISTKSDVWSLGCILYLLLYQKTPFGHIRNVYAKMSAITTPGTSIEY 574

Human   757 PDIP 760
            |.||
  Fly   575 PAIP 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTK	NP_003309.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..410		9/39 (23%)
		PKc_Mps1	523..791	CDD:271033	119/257 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	836..857
Mps1	NP_001262677.1	PKc_Mps1	335..579	CDD:271033	119/257 (46%)
Mps1	NP_001262677.1	S_TKc	337..575	CDD:214567	116/250 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160317
Domainoid	1	1.000	185	1.000	Domainoid score	I3405
eggNOG	1	0.900	-	-		E1_KOG0596
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3702
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005632
OrthoInspector	1	1.000	-	-		oto90948
orthoMCL	1	0.900	-	-		OOG6_103440
Panther	1	1.100	-	-	LDO	PTHR22974
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R740
SonicParanoid	1	1.000	-	-		X4035
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780