DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment C5 and Tep1

DIOPT Version :9

Sequence 1:NP_001304092.1 Gene:C5 / 727 HGNCID:1331 Length:1682 Species:Homo sapiens
Sequence 2:NP_523578.1 Gene:Tep1 / 34937 FlyBaseID:FBgn0041183 Length:1354 Species:Drosophila melanogaster


Alignment Length:1587 Identity:366/1587 - (23%)
Similarity:636/1587 - (40%) Gaps:330/1587 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    29 YVISAPKIFRVGASENIVIQVYGYTEAFDATISI-------KSYPDKKFSYSSGHVHLSSENKFQ 86
            |.:.|||..|..::.|:|:.::..|...:.::|:       :.|.|.: |.||..|....     
  Fly    23 YSVLAPKTLRSNSAYNVVVAIHNTTRTTEVSVSLTGPSLNSRKYVDVQ-SMSSKSVRFDI----- 81

Human    87 NSAILTIQPKQLPGGQNPVSYVYLEVVSK---HFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVK 148
                    ||...|...      |:|:..   .|..|.::....|..:|:|.:||..|.|...::
  Fly    82 --------PKLTEGDYE------LKVMGSGGIEFQNSTKLSFAPDLNWLYIQSDKATYKPGDKIQ 132

Human   149 VRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHI----GIISFPDFKIPSNPRYGMWTIKA 209
            .||..|:.:.:||..:..:. |:....:.::::....|    |:.| .:.::...|..|.||:.|
  Fly   133 FRVLFLDKNTRPAVIDKPIK-IEIRDGDQNLIKSWKDIKPAKGVYS-GELQLSDRPVLGNWTVTA 195

Human   210 KYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNF---IGYKNFKNFEITIKARYFYNKVVTEADV 271
            ..:::...|..  ..|.:||:|.|.|.:....|.   .||     ...||||||.:.|.|....|
  Fly   196 TVQDEGKVTNV--LVVDKYVVPKFEVVVLTAKNVAASAGY-----IRATIKARYTFKKPVKGHVV 253

Human   272 YITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVI 336
            ....|              ::.:.::.|:|...|.|......|.|            |.|...|.
  Fly   254 ATIEG--------------SSTEQSLPIDGEVNVEFPISATAKRL------------LKITAIVT 292

Human   337 ESTGGFSEEAEIPGIKYVLSPY--------KLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVP 393
            |         |:..||:..:.|        ||..:..|...:||:....|..|: :||    |.|
  Fly   293 E---------ELTDIKHNGTAYVTVHQHRHKLEDLFWPTHYRPGVSSEFKTVVR-NLD----GSP 343

Human   394 VTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGY 458
            |..:::.::.|.....:..:.|.:                   |:.::.|:...|||..|:    
  Fly   344 VMDSSKMVNFNVLCCQVSKNFSAS-------------------LQNSIATEHIMLPETCQS---- 385

Human   459 RAIAYSSLS-----QSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKI--------THYNYLIL 510
             .:..|:..     :.|:|          .:.:.|.|.:..|.|.:.|:        |:..|.||
  Fly   386 -CLVTSTFDTAENIERYIY----------KLNKPLMIAINTKKPQLRKLLKINIISDTYLPYFIL 439

Human   511 ---SKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEK 572
               ::|.|:....:|.......|.|....|..:||.:.:.|:||:.|    .|:||...::||..
  Fly   440 TVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYIIDG----VLMSDEKTVDIERD 500

Human   573 CGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSD 637
            ..|.:::..:.:|   .|...|||.:.|...|:|.|..||.:|..::.|  ..|.|        |
  Fly   501 FENTIEILTTNEA---LPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSG--NDLNR--------D 552

Human   638 LGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVK 702
            |      .|||...:. ..|..|||||.:                            .|:.|   
  Fly   553 L------ILNNLATYS-TDLVILTNANIN----------------------------IYRSS--- 579

Human   703 KCCYDGACVNNDETCEQRAARISLGPRCIKAFTEC--CVVASQLRANISHKDMQLGRLHMKTLLP 765
                 |.|..|                  ..:|.|  .::...:..|...|:.....:...|...
  Fly   580 -----GGCYTN------------------PGYTNCTGSLIGRTMFKNEPTKNSGPVPIVGSTRAQ 621

Human   766 VSKPEIRSYFPESWLW-EVHLVPRRKQ--LQFALPDSLTTWEIQGVGIS-NTGICVA-DTVKAKV 825
            .|.|.:|..|||:||: .:..|....:  ::..:||:||:|.|.|..:| .:|:.|. :..:.:|
  Fly   622 ASLPPVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRV 686

Human   826 FKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEG----ICTSESPVIDH-QGTK 885
            |:..|:..|:||||.|||.|.:...|:||....::..|.|...:|    |.|:...|..: :|.:
  Fly   687 FQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVR 751

Human   886 SSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTL 950
            ..|.:  .:..::...::|.:.|.::||..:..:..:.:..:.|.:.|:|..:||::.....|.:
  Fly   752 RKKTL--WIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILKVEADGVQKYVNKAVLI 814

Human   951 DPRGIYGTISRRKEFPYRIPLDLVPKTEI---KRILSVKGLLVGEILSAVLSQ----EGINILTH 1008
            :.:    .::||...|        |:..|   |....::|....|......||    |.::.|.|
  Fly   815 NVQ----RLNRRSLAP--------PEKTIIIEKADNVIEGSETVEFEVCGTSQAPQLEHLDDLVH 867

Human  1009 LPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYS 1073
            ||.|..|..:.:.||......||:..|     ..|..|| .|.|:.::.|....::|:..|.|:|
  Fly   868 LPCGCGEQNMFNFVPSILALSYLKAKN-----RQDQEIE-NKAKRYVETGYQIELNYKRNDGSFS 926

Human  1074 VWKGGSA--STWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKE------NSQY 1130
            .|....|  ||||||:.:|...|..||::.::|.:...|.:||.....| |.|||      ||..
  Fly   927 AWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTD-GKFKELGMVIHNSHG 990

Human  1131 QPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLA 1195
            .|:.|...:.:...||..|:..:..:             ||.|:    .|::.....:...:.||
  Fly   991 SPLALTSFVLLTFFENEEYMPKYKHV-------------IDRAV----EFVVTEVHQSNEPYDLA 1038

Human  1196 ISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYA 1260
            |:|.||||....:..  .::..|.:.|..:|:   :::|..:.:.|.|.         ||||:|.
  Fly  1039 IAALALSLARNRNAY--KVLDKLDKLATRRGD---HKWWTGSDKCKSSE---------VETTSYV 1089

Human  1261 LLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKH 1325
            ||..|.....:...|::.||..::...|||.|:|||:..|..||:|.|.......::||:..:.:
  Fly  1090 LLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQSHASTEAIDIEFWHLN 1154

Human  1326 KGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQ 1390
            :...|.....:..|..:..::..|.:.:.....|.|.|.|.: |..:..:|.|...||.|   |.
  Fly  1155 EDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQL-TYRYNVATKEARPSFKL---TT 1215

Human  1391 DIEASHYRGYGNSDYKRIV--ACASYKP-SREESSSGSSHAVMDISLPTGISANEE---DLKALV 1449
            .::.|| :|       |::  .|.:|.| :..|.:..::.|:|.:.||:|...:.|   |::| :
  Fly  1216 TVKKSH-KG-------RLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCDIEPFADIEA-I 1271

Human  1450 EGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMF 1514
            ..|.::.|..:..:.|:..:  .:...|..|:.........|..|.|:...:|:|:..::..|.|
  Fly  1272 SDVKRVETKNEDTEVHIYFE--KLSPGDRKCLTLEAIYTHAVANLKPSWVRLYDYYATERSATEF 1334

Human  1515 YSTSNIKIQKVCEGAACKCVEADCGQM 1541
            |.. :..:..:|.|       .:||.|
  Fly  1335 YHV-DTSLCDICHG-------NECGNM 1353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C5NP_001304092.1 A2M_N 132..225 CDD:280081 21/96 (22%)
A2M_N_2 478..616 CDD:285005 38/148 (26%)
ANATO 688..756 CDD:237984 9/69 (13%)
A2M 778..865 CDD:278630 29/91 (32%)
complement_C3_C4_C5 999..1306 CDD:239226 91/318 (29%)
A2M_comp 1057..1307 CDD:284982 72/257 (28%)
A2M_recep 1427..1515 CDD:284981 19/90 (21%)
NTR_complement_C5 1533..1682 CDD:239637 3/9 (33%)
Tep1NP_523578.1 A2M_N 116..201 CDD:280081 20/86 (23%)
A2M_N_2 411..542 CDD:285005 38/137 (28%)
A2M 634..726 CDD:278630 29/91 (32%)
A2M_2 859..1135 CDD:239227 89/313 (28%)
A2M_comp 910..1135 CDD:284982 72/256 (28%)
A2M_recep 1245..1335 CDD:284981 19/92 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149958
Domainoid 1 1.000 53 1.000 Domainoid score I11337
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
76.810

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