DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment C5 and Tep3

DIOPT Version :9

Sequence 1:NP_001304092.1 Gene:C5 / 727 HGNCID:1331 Length:1682 Species:Homo sapiens
Sequence 2:NP_523507.2 Gene:Tep3 / 34045 FlyBaseID:FBgn0041181 Length:1469 Species:Drosophila melanogaster


Alignment Length:1656 Identity:366/1656 - (22%)
Similarity:638/1656 - (38%) Gaps:367/1656 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    18 CGAFAFGLRCRYVISAPKIFRVGASENIVIQVYGYTEA--FDATISIKSYPDKKF----SYSSGH 76
            |...|.||   |.|.||...|..:..::.:.::...|:  |...|...||.|.|.    .:|:..
  Fly    23 CQTSAQGL---YSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYTDFKTVELRPFSTQL 84

Human    77 VHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVY 141
            :|      |:..|:.|.:.:....|...|.:.  .....|| :||:..:       .:.|||.:|
  Fly    85 LH------FEIPALRTDRYRLTAEGLGGVQFT--NETQLHF-ESKQHTV-------LVQTDKSIY 133

Human   142 TPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPS-------- 198
            .|...|..||..|:.:||||:....:        .||:.:..|:| |.|:.|.::.:        
  Fly   134 KPGDLVHYRVLILDANLKPARGYGRV--------HVDIKDSGDNI-IRSYKDIRLTNSIYSNELR 189

Human   199 ---NPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARY 260
               :||:|.|:|.....:.   ..|..||:.:::||.|.|.|:...:.| ||:.| ...|::|.|
  Fly   190 LSDSPRFGTWSIVVDVSDQ---EHTQTFEILDHILPKFVVDIDTPKHAI-YKDGK-IAATVRAHY 249

Human   261 -FYNKVVTEA--DVYIT-FGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSL 321
             |...:|.||  .:|.| ||..:...:|      ...:..:.|:|.|...||.|..:     :..
  Fly   250 AFGQPIVGEATLSIYPTFFGSLQPFVND------LITRKVVPIDGNAYFEFDIENEL-----HLK 303

Human   322 EDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKV------- 379
            :|...:||..|:...:|||.....:.:  :...|:.|::..|..|.:..||:|:....       
  Fly   304 QDYERQYLLDALVEEKSTGSVQNYSTV--LTLHLNHYRVEAVKVPSYYIPGVPFEATARIARNDG 366

Human   380 -QVKDSLDQL------VGGVPVTLN--AQTIDVNQE--------TSDLDPSKSVTRVDDGVASFV 427
             |::|...|:      |.|.....|  |.::|.:.|        ..|.|...|:.....||.|.|
  Fly   367 GQLRDFNPQITAYLTNVYGSSEMYNRTAYSLDASGEIKMKFTVPIGDRDEFHSIIVDYQGVISEV 431

Human   428 LNLPS----GVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHL 488
            ..:||    ....:...|..|.|                                    .|.:.:
  Fly   432 GKIPSKHLHSKNYITAKVLNDRP------------------------------------TVNQEI 460

Human   489 NIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVT 553
            :::|...:|    |.::.|.::.:|.|| .......:..::.:|....:..|:|.:.||||.::.
  Fly   461 SVVVRSFAP----IKYFMYQVVGRGDII-LSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTVID 520

Human   554 GEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYS-PGQTVSLNMATGMDSWVALAAVDSAVYG 617
            |    |.|.|...:.:||...|.:||    ||...: |||.:.:.::|...|:|.|..||.....
  Fly   521 G----EFVYDEQVIQLEENLLNAVQV----DAPIRAPPGQDIDIGISTKPYSYVGLMLVDQNAND 577

Human   618 VQRG---AKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANAD---DSQENDEPCK 676
            ::.|   ..|.|....:..|.||:....|.....:.|        :|.:|.|   :.:....|  
  Fly   578 LRSGHDLTHKRLMDALRSYELSDVNTPMGSPGKESGV--------ITMSNTDYFIEKEAESNP-- 632

Human   677 EILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVA 741
                   .|.:::.....:.|.:.|:|                    ..:||             
  Fly   633 -------ALDREVSTGPEEDKLTTVRK--------------------TDIGP------------- 657

Human   742 SQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLW---EVHLV----------------P 787
                   :||      :.:.||.|.......||.|:.: |   .||::                .
  Fly   658 -------AHK------IEVNTLPPGKGRYAFSYTPKPF-WHNPRVHVMRDPADTWLFLNISASSD 708

Human   788 RRKQLQFALPDSLTTW--------EIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQ 844
            .|..:...:|..:|:|        .:.|:|:|      ....|.:.:|:.::...:|||:.|.|.
  Fly   709 GRNSIHRRIPSEMTSWVVSAFALDPVNGLGLS------PPNGKLEAYKEFYISTELPYSIKRDEL 767

Human   845 IQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSK--CVRQK---VEGSSSHLVTF 904
            |.:...|:|.|.|.:.  |:::........:.|.:|.:.|...|  ..|::   |.|.|:..|:|
  Fly   768 IAIPFVVHNNRDSDLN--VEVTFYNSALDFDFPQLDPKATNQPKVELYRRRSLQVPGRSARSVSF 830

Human   905 TVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPR------GIYGTISR-- 961
            .|.|..:|              .:|||.:..       .|.:|.|::..      |....|:|  
  Fly   831 IVTPKRVG--------------PLLVKAMAA-------SSQAGDTVEQNLLVEHPGAMERINRGF 874

Human   962 ----------RKEFPYRIPLDLVPKT---EIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGS 1013
                      |:.....:|.:.:|::   |:..:..:.|.|||.:.|.:|          ||.|.
  Fly   875 LFELNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLIL----------LPTGC 929

Human  1014 AEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGG 1078
            .|..:::.||...|..||     ..:....|.:| .:....|..|...|:.||:.:.::|.:  |
  Fly   930 GEQTMVNFVPNLIVLRYL-----GRLRQLTPEVE-LRATNNLAIGYQRILYYRHENGAFSAF--G 986

Human  1079 ----SASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTL 1139
                .:||||||:..|.|.|...:.:.:.|.:..:|.:| .:.|..||.|:|         :|.:
  Fly   987 LDIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYL-GSVQSANGGFEE---------RGDV 1041

Human  1140 PVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLG 1204
            .....::.:.||||..:.:.:..|:.|  :....:.||.:|:......:.:...:||..|.||  
  Fly  1042 FERFGDDGISLTAFVTLALMENVDLYP--EYRNNINKALDFITRGLDGSSNLHAMAIGTYVLS-- 1102

Human  1205 DKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVP--NTGTARMVETTAYALLTSLNL 1267
               .....:..:.|:|...:..|....::|.......:...|  |...:..:|.:|||.|..|..
  Fly  1103 ---RANHNAKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSPWYNATRSVNIEISAYAALALLEN 1164

Human  1268 KDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNY 1332
            ..:....||:.||.:::...|||.::|||:..::.|..::........::.|...| .:||....
  Fly  1165 NLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAERFSSQGNNLQIGFHY-GEGAETII 1228

Human  1333 KMTDKNFLGRPVEVLLND--DLIVS-TGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEA 1394
            .:..:|.|......|.|:  :|.|| ||.|..||.|..|   :.|:.:.....|.|  |......
  Fly  1229 NVNAENSLALQTVELPNNLKNLSVSATGRGMALAQVSYT---YNTNVTSAWPRFVL--DPTVNRN 1288

Human  1395 SHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDY 1459
            ||      :||..:.||||:.....|:...|:.|||::.||:|...:.:.|..|.........:.
  Fly  1289 SH------ADYLHLSACASFVSVVGENEQRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVET 1347

Human  1460 QIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQK 1524
            |.::..|::..:.:...: :|.....::..:|....|....:|:|:...::...||......|..
  Fly  1348 QNRNTKVVIYFDYLDRRE-VCPTLHAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKSNICD 1411

Human  1525 VCEGAACKCVEADCGQMQEELDLTISAETRK 1555
            :||       .|:||      ||...||.|:
  Fly  1412 ICE-------HANCG------DLCEKAEKRE 1429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C5NP_001304092.1 A2M_N 132..225 CDD:280081 27/103 (26%)
A2M_N_2 478..616 CDD:285005 35/138 (25%)
ANATO 688..756 CDD:237984 7/67 (10%)
A2M 778..865 CDD:278630 23/113 (20%)
complement_C3_C4_C5 999..1306 CDD:239226 73/312 (23%)
A2M_comp 1057..1307 CDD:284982 61/255 (24%)
A2M_recep 1427..1515 CDD:284981 15/87 (17%)
NTR_complement_C5 1533..1682 CDD:239637 8/23 (35%)
Tep3NP_523507.2 A2M_N 124..215 CDD:280081 26/109 (24%)
A2M_N_2 448..573 CDD:285005 37/173 (21%)
A2M 697..787 CDD:278630 20/97 (21%)
A2M_2 918..1203 CDD:239227 75/319 (24%)
A2M_comp 967..1200 CDD:284982 60/251 (24%)
A2M_recep 1313..1402 CDD:284981 16/89 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149959
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
65.810

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