Protein Alignment C5 and Tep2

DIOPT Version :9

• Sequence 1: NP_001304092.1
• Gene: C5 / 727
• HGNCID: 1331
• Length: 1682
• Species: Homo sapiens
• Sequence 2: NP_523506.1
• Gene: Tep2 / 34044
• FlyBaseID: FBgn0041182
• Length: 1420
• Species: Drosophila melanogaster
• Alignment Length: 1627
• Identity: 380/1627 - (23%)
• Similarity: 671/1627 - (41%)
• Gaps: 349/1627 - (21%)

Human    29 YVISAPKIFRVGASENIVIQVYGYTEAFDATISIK--SYPDKKFSYSSGHVHL---SSEN-KFQN 87
            |.:..|...|..:..|:|:.|:.........:|:.  ||.:.|      .:.|   |::| :|:
  Fly    23 YSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETK------QIELPPMSTQNVEFE- 80

Human    88 SAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVY 152
                  .||...|..|..:.....||   |..|.::........:|:.|||..|.|...|:.|:.
  Fly    81 ------VPKLATGNYNLSAEGVSGVV---FKNSTKLNYADKKPSVFVQTDKATYKPADLVQFRIL 136

Human   153 SLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHI----GIISFPDFKIPSNPRYGMWTIKAKYKE 213
            .|:::.:|||.|..::.|..:|:: :.::::..:    |:.| .:.::...|..|.|.|....
  Fly   137 FLDENTRPAKIEKPISVIIIDGAQ-NRIKQLSDVKLTKGVFS-GELQLSEQPVLGTWKISVSV-- 197

Human   214 DFSTTGTAYFEVKEYVLPHFSVSIE-PEYNFIGYKNFKNFEITIKARYFYNKVVT-EADVYI--T 274
            |.....|..|||.:||||.|.|.:: |:...|..|..|   .||:|:|.|.|.|. :|.|.:  :
  Fly   198 DGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIK---ATIRAKYTYGKPVKGKATVSMERS 259

Human   275 FGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYL----YIAVTV 335
            :|...||..:..:     .:.|:.::|...|.||       :.:::   ...:||    ..||..
  Fly   260 YGYFGDLNANGNK-----QEKTIDVDGKGHVEFD-------IIHWA---QRGQYLPPIKLFAVVT 309

Human   336 IESTGGFSEEAEIPGI----KYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTL 396
            .|.||. .:.|....:    :|.:.||:     .|...:....:..:|.||:     |.|.|||.
  Fly   310 EELTGN-KQNATATVVLHQQRYSIEPYE-----RPEHFEANKSFIYQVVVKN-----VDGSPVTN 363

Human   397 NAQTIDVNQETSDL---DPSKSVTRV-------DDGVASFVLNLPSGVTVLEFNVKTDAPDLPEE 451
            :|:.:.:..:.|..   :||.. ||:       ::|:|:|.:.||                   :
  Fly   364 SAKNVKIGFDKSYSYFHEPSPK-TRINFEAPVNENGIATFNVRLP-------------------D 408

Human   452 NQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVG------------EHLNIIVTPKSP------- 497
            :.:|. ||..|         ..|.::|    .:|            |.|.|.|..|.|
  Fly   409 SDSRY-YRIFA---------SFDGSEN----TIGSISKFEPTPMSREPLKIQVNTKKPRLGEQVS 459

Human   498 ----YIDKITHYNYLILSKGKIIHFGTREKFSD--------ASYQSINIPVTQNMVPSSRLLVYY 550
                .|:.:.::.|.|:::|.:|       .||        .:| ::....|.:|||.:.:.|||
  Fly   460 FDVVSIEDLPYFVYTIVARGNVI-------LSDYVDVPDGQKTY-TVKFTPTFSMVPKATIYVYY 516

Human   551 IVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAV 615
            :|..    :|..:...::.|::..|.:.|....:|   .|.:.|.|.:.|..||:|.|..||.:|
  Fly   517 VVNN----DLQFEEKTIDFEKEFSNSIDVSAPTNA---KPSEEVKLRIKTDADSFVGLLGVDQSV 574

Human   616 YGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVF---------------HLAGLTFLTNANA 665
            ..::.|.....:.:|                |:.|::               ..:||..|||||
  Fly   575 LLLKSGNDLSQDDIF----------------NSLNIYQTSTPWMNGYGRYPGQTSGLVTLTNAN- 622

Human   666 DDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISL---- 726
                          .|..|....:..:....:|..:.:..|                |:.:
  Fly   623 --------------YPYNTGPLVMSYVFEGSRHPWITRPRY----------------RVGIRGDS 657

Human   727 GPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPE---IRSYFPESWLWEVHLVPR 788
            |.|                  ||.....|...::|.:|....|:   ||..|||:|.:| ::...
  Fly   658 GDR------------------ISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFE-NVGEE 703

Human   789 RKQLQFALPDSLTTWEIQGVGISNT-GICVA-DTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTV 851
            ...|...:||::|:|.:.|..::.| ||.:. :..|.:||:..|:..|:||||.|||.|.:...:
  Fly   704 EFTLTKKIPDTITSWVVTGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVI 768

Human   852 YNYRTSGMQFCVKMSAVE---GICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGL 913
            :||....:...|.|...:   ....:.:.|::....:..:..|..:..:|...|:|.:.|..:|.
  Fly   769 FNYLDKTLDADVVMDNSDQEYEFTEATNEVLEKAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGF 833

Human   914 HNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYR----IPLDLV 974
            ..:..:..:....:.:.:.|:|.||||       ...:.|.::..:..:.|....    ||.::|
  Fly   834 TTLKITATSALAGDAIHQKLKVEPEGV-------TLFENRAVFINLKDQPEMSQSLDADIPNEVV 891

Human   975 PKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLE-TGNHWN 1038
            |::|.     ::..:||::|...|  :.::.|..:|.|..|..:::.||...|..||| ||...
  Fly   892 PQSEF-----IEFSVVGDLLGPTL--QNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKL- 948

Human  1039 IFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVW--KGGSASTWLTAFALRVLGQVNKYVEQ 1101
                 |.:| .|.:|.|:.|....::|::.|.|||.:  ...|.||||||:.:|...|...|.:.
  Fly   949 -----PSVE-SKARKFLEIGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDI 1007

Human  1102 NQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICP 1166
            :...|...|.:||.. |.::|.|.|         .|.|...|.:|.|.||:|.::...:..::.|
  Fly  1008 DPKVITAGLDFLVSK-QKESGEFPE---------VGKLFDNANQNPLALTSFVLLAFFENHELIP 1062

Human  1167 LVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIY 1231
              |..:|:.||..::.|........::|||:|.||.|.  .|||...:::.|:..|..:.:
  Fly  1063 --KYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLA--KHPQSEKVIAKLESVARKEND---- 1119

Human  1232 RFWKDNLQHKDSSVPNTG----------TARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRY 1286
            |.|      ...:..:||          .:..||.|:|.||..|.........|:||||..::..
  Fly  1120 RMW------WSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNS 1178

Human  1287 GGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDD 1351
            .|||.|||||:..::.||:::........:|||:.|...: :.:..|:..:|.|     ||...|
  Fly  1179 NGGFSSTQDTVIGLQALTKFAYKTGSGSGTMDIEFSSAGE-SKNTIKVNPENSL-----VLQTHD 1237

Human  1352 LIVS------TGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVA 1410
            |..|      |..|:|.|.|.: :..:..:..|:..||.:....:|..         :....:..
  Fly  1238 LPKSTRKVDFTAKGTGSAMVQL-SYRYNLAEKEKKPSFKVTPTVKDTP---------NQLLIVDV 1292

Human  1411 CASYKPSRE-ESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQL-FTDYQIKDGHVILQLNSI 1473
            ||.|.|..: :....|:.|||:|:||:|...:...| ..::.||:: ..:.:..|..|::..:|:
  Fly  1293 CAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSL-GKIQAVDRVKRVETKNSDSTVVVYFDSL 1356

Human  1474 PSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADC 1538
            ...|..|:.....:...|....||:.::|:|:..:::.|.:|...: .:..:|||       |||
  Fly  1357 TPGDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKS-SLCDICEG-------ADC 1413

Human  1539 GQ 1540
            |:
  Fly  1414 GE 1415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C5	NP_001304092.1	A2M_N	132..225	CDD:280081	24/96 (25%)
		A2M_N_2	478..616	CDD:285005	39/168 (23%)
		ANATO	688..756	CDD:237984	7/71 (10%)
		A2M	778..865	CDD:278630	27/88 (31%)
		complement_C3_C4_C5	999..1306	CDD:239226	93/319 (29%)
		A2M_comp	1057..1307	CDD:284982	76/261 (29%)
		A2M_recep	1427..1515	CDD:284981	21/88 (24%)
		NTR_complement_C5	1533..1682	CDD:239637	4/8 (50%)
Tep2	NP_523506.1	A2M_N	115..209	CDD:280081	24/97 (25%)
		A2M_N_2	445..576	CDD:285005	36/145 (25%)
		A2M	694..782	CDD:278630	27/88 (31%)
		A2M_2	909..1198	CDD:239227	94/321 (29%)
		A2M_comp	961..1199	CDD:284982	76/261 (29%)
		A2M_recep	1308..1398	CDD:284981	22/90 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149960
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810