Protein Alignment CAPN5 and CalpC

DIOPT Version :10

• Sequence 1: NP_001412250.1
• Gene: CAPN5 / 726
• HGNCID: 1482
• Length: 680
• Species: Homo sapiens
• Sequence 2: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 614
• Identity: 166/614 - (27%)
• Similarity: 267/614 - (43%)
• Gaps: 135/614 - (21%)

Human    13 YSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKYSGHSLAPHRPGWGDARRMENV 77
            |..:..|||.:.||:|||.|||...|::|..||....:||                    |:.::
  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWK--------------------RIMDL 49

Human    78 PRPGSSGCPSSSLRARDLGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIP 142
            ...||....::|..|         .:|::..:..|:..|::|:.|.|:....|:|..:|:.:|:|
  Fly    50 ADSGSGAVAANSSAA---------PVFLNESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVP 105

Human   143 DWKEQEWDPEKPNAYAGIFHFHFWRFGEWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAY 207
            .      |....:|: |:|.|..|..||||:|::||||||:|.:|.:....:.|.||.||:|||.
  Fly   106 A------DQTLASAH-GVFRFRLWWCGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAI 163

Human   208 AKLAGCYQALDGGNTADALVDFTGGVSEPIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASI 272
            |||.|.|:||..|..:|.|.|..|||...:.:...:.      |.|..:.:|........::...
  Fly   164 AKLHGSYEALKYGTRSDGLTDLLGGVVRQMPILSDNI------RPQTLKELLTTTCIVTCLADKS 222

Human   273 KAVTAADMEARLACGLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRN-----PWGER-EW 331
            ..|...::..|:..|::....|.::.:.||:...|       :.:.::.|::     |:||: .:
  Fly   223 ATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMG-------DSVQLVCLKDTFSSKPFGEKTHF 280

Human   332 NGPWSDTSEEWQKVSKSEREKMGVTVQDDGEFWMTFEDVCRYFT---------------DIIKCR 381
            .|.||..|:.|::||:.||.:: :.....||||::|.|....|:               :::|.|
  Fly   281 LGDWSPMSKTWERVSQVERARL-IRQLGPGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSR 344

Human   382 VINTSHLSIHKTWEEARLHGAWTLHEDPRQNRG---GGCINHKDTFFQNPQYIFEVKKPEDEVLI 443
            .::         |:.....|.|        .||   |||.|| ::|..|||.:..| :.|.:::|
  Fly   345 PLH---------WKMKMHQGQW--------KRGVTAGGCRNH-ESFHINPQLLISV-QDEQDLVI 390

Human   444 CIQQRPKRSTRREGKGENLAIGFDIYKVEENRQYRMHSLQHK--------AASSIYINSRSVFLR 500
            .:.|.    |..|.|    .|||.:|..:  .:|.:.....|        ..:|.|.|:|.|...
  Fly   391 ALNQH----TAVEPK----VIGFTMYTWD--GEYMLSECLQKDFFKNHVSYLNSDYGNTRHVSYH 445

Human   501 TDQPEGRYVIIPTTFEPGHTGEFLLRVFTDVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLG 565
            |....|.||:||||:||.....|.:|:.     .....||     :|         |.||..:
  Fly   446 THLEAGHYVLIPTTYEPAEEAHFTVRIL-----GTGSFRL-----SC---------LETQTMI-- 489

Human   566 AAGLKDSPTGANSYVIIKCEGDKVRSAVQ 594
               |.|......|....:|.|.||:|..|
  Fly   490 ---LLDPFPALKSTDAERCGGPKVKSVCQ 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAPN5	NP_001412250.1	Peptidase_C2	27..381	CDD:459889	100/374 (27%)
		Calpain_III	392..538	CDD:238132	44/156 (28%)
		C2_Calpain	555..678	CDD:176011	12/40 (30%)
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	104/371 (28%)
		Calpain_III	346..483	CDD:238132	47/184 (26%)
		EFh_PEF	515..680	CDD:355382	1/1 (100%)
		EF-hand motif	515..543	CDD:320054	1/1 (100%)
		EF-hand motif	556..585	CDD:320054
		EF-hand motif	586..615	CDD:320054
		EF-hand motif	622..650	CDD:320054
		EF-hand motif	652..680	CDD:320054