Protein Alignment CAPN5 and CalpC

DIOPT Version :9

• Sequence 1: XP_011543527.1
• Gene: CAPN5 / 726
• HGNCID: 1482
• Length: 680
• Species: Homo sapiens
• Sequence 2: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 585
• Identity: 162/585 - (27%)
• Similarity: 260/585 - (44%)
• Gaps: 117/585 - (20%)

Human    53 YSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPAVRWKRPKGICED-----------PRLFVD 106
            |..:..|||.:.||:|||.|||...|::|..||....:|||...:.:.           ..:|::
  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLN 69

Human   107 GISSHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFGEW 171
            ..:..|:..|::|:.|.|:....|:|..:|:.:|:|.      |....:|: |:|.|..|..|||
  Fly    70 ESAEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPA------DQTLASAH-GVFRFRLWWCGEW 127

Human   172 VDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEP 236
            |:|::||||||:|.:|.:....:.|.||.||:|||.|||.|.|:||..|..:|.|.|..|||...
  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVRQ 192

Human   237 IDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVTAADMEARLACGLVKGHAYAVTDVRK 301
            :.:...:.      |.|..:.:|........::.....|...::..|:..|::....|.::.:.|
  Fly   193 MPILSDNI------RPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDK 251

Human   302 VRLGHGLLAFFKSEKLDMIRLRN-----PWGER-EWNGPWSDTSEEWQKVSKSEREKMGVTVQDD 360
            |:...|       :.:.::.|::     |:||: .:.|.||..|:.|::||:.||.:: :.....
  Fly   252 VKTLMG-------DSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARL-IRQLGP 308

Human   361 GEFWMTFEDVCRYFT---------------DIIKCRVINTSHLSIHKTWEEARLHGAWTLHEDPR 410
            ||||::|.|....|:               :::|.|.::         |:.....|.|
  Fly   309 GEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLH---------WKMKMHQGQW------- 357

Human   411 QNRG---GGCINHKDTFFQNPQYIFEVKKPEDEVLICIQQRPKRSTRREGKGENLAIGFDIYKVE 472
             .||   |||.|| ::|..|||.:..| :.|.:::|.:.|.    |..|.|    .|||.:|..:
  Fly   358 -KRGVTAGGCRNH-ESFHINPQLLISV-QDEQDLVIALNQH----TAVEPK----VIGFTMYTWD 411

Human   473 ENRQYRMHSLQHK--------AASSIYINSRSVFLRTDQPEGRYVIIPTTFEPGHTGEFLLRVFT 529
              .:|.:.....|        ..:|.|.|:|.|...|....|.||:||||:||.....|.:|:.
  Fly   412 --GEYMLSECLQKDFFKNHVSYLNSDYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRIL- 473

Human   530 DVPSNCRELRLDEPPHTCWSSLCGYPQLVTQVHVLGAAGLKDSPTGANSYVIIKCEGDKVRSAVQ 594
                .....||     :|         |.||..:     |.|......|....:|.|.||:|..|
  Fly   474 ----GTGSFRL-----SC---------LETQTMI-----LLDPFPALKSTDAERCGGPKVKSVCQ 515

Human   595  594
              Fly   516  515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAPN5	XP_011543527.1	CysPc	53..391	CDD:128526	103/369 (28%)
		Calpain_III	394..533	CDD:279416	44/149 (30%)
		C2_Calpain	555..678	CDD:176011	12/40 (30%)
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	100/342 (29%)
		Calpain_III	346..483	CDD:238132	47/184 (26%)
		FRQ1	<567..648	CDD:227455

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920