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Protein Alignment TSHR and rk

DIOPT Version :9

Sequence 1:	NP_000360.2	Gene:	TSHR / 7253	HGNCID:	12373	Length:	764	Species:	Homo sapiens
Sequence 2:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	248/776 - (31%)
Similarity:	363/776 - (46%)	Gaps:	143/776 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    11 LLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRI--PSLPPSTQTLKLIETHLRTIPSHAFS 73
            |:..||..|..:.         |.::..:|...::.|  ..||.|.|.|.:....|.||...||.
  Fly   358 LISSLPEGLSKLS---------QLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFR 413

Human    74 NLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEI--RNTRNLTYIDPDALKELPLLKFLGIFNT 136
            .:..:.::.:|...||:     ||..|.....:||  .:...:..:..:..::.|.||.|.:...
  Fly   414 GMSKLRKLILSDVRTLR-----SFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTN 473

Human   137 GLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTK 201
            .||..|:|:.                             |.:...|.|.:|....:||..|||.|
  Fly   474 SLKRIPNLSS-----------------------------CRDLRLLDLSSNQIEKIQGKPFNGLK 509

Human   202 -LDAVYLNKNKYLTVIDKDAFGGV--------------------YSGPSLLD---VSQTSVTALP 242
             |:.:.|:.|: :..:.:|||.|:                    :||.:.|:   :.......||
  Fly   510 QLNDLLLSYNR-IKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELP 573

Human   243 SKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAF------KNQKKIRGILESL-- 299
            ..||..|..|...|...|::.|...:|..:....|||..|||||      .:|||...:.|::
  Fly   574 ESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLF 638

Human   300 ---------MCNESSMQSLRQRKSVN-ALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYV 354
                     :.|.|.|....|..::: .|.:.:|..:|..:.
  Fly   639 PSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAIN----------------------- 680

Human   355 FFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICG---------DSED-----MVCTPKSDEF 405
            |.|||.....| ||...:..||..:..|.....|..|         .:||     :.|.|....|
  Fly   681 FNEEQLQTQTG-GQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPF 744

Human   406 NPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLI 470
            .||.|:..:..||..||.|.||:||||..|:.:||.|..|::|||||:||||.|||.||:||.::
  Fly   745 LPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGIL 809

Human   471 ASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRL 535
            |.||..|..|:...||.||....|..:||..|.:||||||||.||||||.||||.|:.|::::.|
  Fly   810 AIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSL 874

Human   536 RHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTET-PLALAYIVFVLTLNIVAFVIVCC 599
            :.|..||..|||...::||:||||:|.|.|.::|||.:|.| |.:|.|::.::.:|..||:.:..
  Fly   875 KQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMG 939

Human   600 CYVKIYITVRNPQ-YNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILL 663
            ||:|:|..:|..| :|  ..|::||||||:|:||||:|.:||:|::::||....||::..:||..
  Fly   940 CYLKMYWAIRGSQAWN--TNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFT 1002

Human   664 VLFYPLNSCANPFLYAIFTKAFQRDVFILLSKF-----------GICKRQAQAYRGQRVPP 713
            |...|||||.|||||||.||.|::|...|...|           |.....|:..||...||
  Fly  1003 VFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGGGPGGRGAVARTKRGDLPPP 1063

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.