Protein Alignment TSG101 and tsg101a

DIOPT Version :10

• Sequence 1: NP_006283.1
• Gene: TSG101 / 7251
• HGNCID: 15971
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_001002089.1
• Gene: tsg101a / 415179
• ZFINID: ZDB-GENE-030217-1
• Length: 390
• Species: Danio rerio
• Alignment Length: 392
• Identity: 332/392 - (84%)
• Similarity: 353/392 - (90%)
• Gaps: 9/392 - (2%)

Human     3 VSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNT 67
            |:|..||||:.:||||||||||..|||:.|||||||:|:|||||||||:||:||||:||.||||.
Zfish     4 VNEGALKKMLKQYKYRDLTVREITNVISQYKDLKPVMDAYVFNDGSSRDLMSLTGTVPVSYRGNV 68

Human    68 YNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMI 132
            ||||:|||||||||||||||||||||:|.||||||:|||||||||||||||||||||.|||||||
Zfish    69 YNIPVCLWLLDTYPYNPPICFVKPTSAMMIKTGKHIDANGKIYLPYLHEWKHPQSDLYGLIQVMI 133

Human   133 VVFGDEPPVFSRPISASYPPY---QATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGG 194
            ||||:||||||||  .:.|||   |||||||.||||||| .:|||  |...||.||||.|||.|.
Zfish   134 VVFGEEPPVFSRP--TTQPPYQAFQATGPPNQSYMPGMP-AVSPY--GPNQNPCGYPGYPYPGGN 193

Human   195 PYPATTS-SQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKR 258
            .||||.. |.|.||.|||||||||||||.|||||||||||||||||||||||||||||||:||||
Zfish   194 AYPATGGPSHYTSQTPVTTVGPSRDGTIGEDTIRASLISAVSDKLRWRMKEEMDRAQAELDALKR 258

Human   259 TEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAP 323
            |||||||||||||:||:||||||||||:|||||||||||||.|||||||||||||||:|||||||
Zfish   259 TEEDLKKGHQKLEDMVSRLDQEVAEVDRNIELLKKKDEELSEALEKMENQSENNDIDDVIIPTAP 323

Human   324 LYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSD 388
            |||||||.|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
Zfish   324 LYKQILNRYAEENAIEDTIFYLGEALRRGVIDLEVFLKHVRLLSRKQFQLRALMQKARKTAGLSD 388

Human   389 LY 390
            ||
Zfish   389 LY 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSG101	NP_006283.1	UEV	21..139	CDD:399041	100/117 (85%)
		Interaction with CEP55	158..162		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..220		16/22 (73%)
		COG4372	211..>349	CDD:443500	129/137 (94%)
		Vps23_core	316..375	CDD:462803	55/58 (95%)
		PTAP motif	320..323		2/2 (100%)
tsg101a	NP_001002089.1	UEV	22..140	CDD:399041	100/117 (85%)
		COG4372	<241..>365	CDD:443500	115/123 (93%)
		Vps23_core	316..375	CDD:462803	55/58 (95%)