DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TSG101 and TSG101

DIOPT Version :9

Sequence 1:	NP_006283.1	Gene:	TSG101 / 7251	HGNCID:	15971	Length:	390	Species:	Homo sapiens
Sequence 2:	NP_524120.1	Gene:	TSG101 / 39881	FlyBaseID:	FBgn0036666	Length:	408	Species:	Drosophila melanogaster

Alignment Length:	411	Identity:	208/411 - (50%)
Similarity:	273/411 - (66%)	Gaps:	31/411 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     2 AVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGN 66
            ||.|:|:.|.:|||||...|.::.|:|:|.::.|...|..:|||||||:||..:.|||||.|:.|
  Fly     3 AVEETQITKYLSKYKYVAATKKDVVDVVTSFRSLTYDLQRFVFNDGSSKELFTIQGTIPVVYKNN 67

Human    67 TYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVM 131
            ||.||||:||:||:|.|.|:||||||.:|.||...:||.|||:||||||:|:...||||.|||||
  Fly    68 TYYIPICIWLMDTHPQNAPMCFVKPTPTMQIKVSMYVDHNGKVYLPYLHDWQPHSSDLLSLIQVM 132

Human   132 IVVFGDEPPVFSRPISASYPPYQATGPPNTSYM--PGMPGGIS---PYP-------SGYPPNPSG 184
            ||.|||.|||:|:|......||     |..|||  ||.|||.:   |||       |.:||.|:|
  Fly   133 IVTFGDHPPVYSKPKEQIAAPY-----PTNSYMPQPGAPGGSNSFLPYPTAGGAGGSNFPPYPTG 192

Human   185 YPGCPYPP-------GGPYPA------TTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSD 236
            ....||||       |..|||      .|:..||.........||..|||:|:.|:||:|||:.|
  Fly   193 SNVGPYPPTPAGPAGGSGYPAYPNFIQPTAGGYPPAAGYNPSNPSSTGTITEEHIKASIISAIDD 257

Human   237 KLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSA 301
            |||.|::|::::.|||:..|.||:::|.:|..|::.::.||::|..::.|||.:||.|::||..|
  Fly   258 KLRRRVQEKVNQYQAEIETLNRTKQELLEGSAKIDAIIERLEREHIDMQKNISILKDKEQELEKA 322

Human   302 LEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLL 366
            ||.:|:....|. ||.:..|||||:|:||.||:|.|.||.|:||||.||.|||||:.||||||.|
  Fly   323 LEDLESAEAINP-DEAVTTTAPLYRQLLNAYADEAATEDAIYYLGEGLRGGVIDLETFLKHVRQL 386

Human   367 SRKQFQLRALMQKARKTAGLS 387
            |||||.|||.|||.|:.|||:
  Fly   387 SRKQFILRATMQKCRQKAGLA 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TSG101	NP_006283.1	UEV	21..139	CDD:399041	70/117 (60%)
		Interaction with CEP55	158..162		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..220		6/27 (22%)
		DUF1640	<236..292	CDD:400241	21/55 (38%)
		Vps23_core	316..375	CDD:401418	40/58 (69%)
		PTAP motif	320..323		1/2 (50%)
TSG101	NP_524120.1	UEV	22..140	CDD:283415	70/117 (60%)
		ARS2	<149..227	CDD:282772	36/102 (35%)
		TBPIP	<242..353	CDD:284512	50/110 (45%)
		Vps23_core	336..393	CDD:286532	38/53 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148018
Domainoid	1	1.000	162	1.000	Domainoid score	I3992
eggNOG	1	0.900	-	-		E1_KOG2391
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4584
Inparanoid	1	1.050	391	1.000	Inparanoid score	I2003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54978
OrthoDB	1	1.010	-	-		D1435538at2759
OrthoFinder	1	1.000	-	-		FOG0001267
OrthoInspector	1	1.000	-	-		oto90988
orthoMCL	1	0.900	-	-		OOG6_102944
Panther	1	1.100	-	-	LDO	PTHR23306
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5678
SonicParanoid	1	1.000	-	-		X3220
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800