Protein Alignment TSG101 and sst6

DIOPT Version :10

• Sequence 1: NP_006283.1
• Gene: TSG101 / 7251
• HGNCID: 15971
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_001018287.1
• Gene: sst6 / 3361461
• PomBaseID: SPAC11H11.01
• Length: 487
• Species: Schizosaccharomyces pombe
• Alignment Length: 419
• Identity: 85/419 - (20%)
• Similarity: 146/419 - (34%)
• Gaps: 136/419 - (32%)

Human    73 CLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQS--DLLGLIQVMI--- 132
            |:.:...||..|||     ...:..|.|||     |.....|..||:.:|  ::..|:|.:|
pombe    81 CITVRSYYPSQPPI-----VQLLDEKGGKH-----KYTSLLLQLWKNERSVFNIYRLVQALIKQD 135

Human   133 ------------------------VVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISP 173
                                    ....:.|||    |.|.  |:.::...:...:|.:|..:.|
pombe   136 FEREHTSPPELPTKLVNTIEKLKVKEENEAPPV----IPAK--PFSSSSEQHFRKVPALPSKLPP 194

Human   174 YP----------SGYPPNPSGYPGCPYPPG-GPYPATT-------------SSQYPSQPPVTTVG 214
            .|          .....|.|.:....:... .|:.||:             ||..|:|.|:....
pombe   195 KPLKITANSSLGQETNSNSSSFQSTLFSLNTAPFSATSQQLVHDSVSLRRPSSNIPAQKPIPPKP 259

Human   215 PSRDGTISEDTIRASLISAVSDKLRWRMKEEMDR-----------------AQAELNALKRTEED 262
            ...:..|::||  .||....|.......|.::.:                 :|:.||.:....|.
pombe   260 EQNEIIITKDT--PSLKDKYSKPALLPQKPKVSKGQIVQQVSVFSTGKKIESQSLLNLIDTDIET 322

Human   263 LKKGHQKL---------------------------EEMVTR-------------LDQE---VAEV 284
            ..||..:|                           |:.:::             ||||   :..:
pombe   323 PLKGSSELLYSEDFKPNVDPVKIQQILHKQNKIIEEKWISQIRISKNLEVKQRLLDQERHALETL 387

Human   285 DKNIE----LLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYL 345
            .||||    :|.|:..:...||:|::|..:.:..:..|||:....| ...|..::..:::.|..|
pombe   388 AKNIENNRFILGKRRRKAREALQKLDNLKDLSVQELFIIPSERELK-YYELKRKDEKLDEGIRAL 451

Human   346 GEALRRGVIDLDVFLKHVRLLSRKQFQLR 374
            .:||....|....:||.::||:|:||.:|
pombe   452 NQALHHESIMPASWLKGIKLLARQQFLIR 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSG101	NP_006283.1	UEV	21..139	CDD:399041	18/94 (19%)
		Interaction with CEP55	158..162		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..220		7/34 (21%)
		COG4372	211..>349	CDD:443500	36/201 (18%)
		Vps23_core	316..375	CDD:462803	18/59 (31%)
		PTAP motif	320..323		1/2 (50%)
sst6	NP_001018287.1	Vps23_core	<435..480	CDD:462803	13/44 (30%)