Protein Alignment TSG101 and tsg-101

DIOPT Version :9

• Sequence 1: NP_006283.1
• Gene: TSG101 / 7251
• HGNCID: 15971
• Length: 390
• Species: Homo sapiens
• Sequence 2: NP_500364.2
• Gene: tsg-101 / 182474
• WormBaseID: WBGene00015658
• Length: 425
• Species: Caenorhabditis elegans
• Alignment Length: 427
• Identity: 165/427 - (38%)
• Similarity: 248/427 - (58%)
• Gaps: 47/427 - (11%)

Human     3 VSESQLKKMVSKY--KYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRG 65
            :|..|:::.:.:.  ||.|...::.:..::.:|||.|..|:::|.||..|....|.|||||.|:|
 Worm     1 MSAHQVQQCLQRAGGKYADSAKKDIIGALSQFKDLSPGTDTFMFPDGKRRTAFRLKGTIPVYYKG 65

Human    66 NTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQV 130
            ..||||:.::|.||:||..|||:|.|||:|.||..:||:..||::||||:||:.|..||.||:||
 Worm    66 ACYNIPVTVYLWDTHPYYAPICYVNPTSTMVIKESEHVNKEGKVFLPYLNEWRFPGYDLSGLLQV 130

Human   131 MIVVFGDEPPVFSRPISASYPPYQATGP-----------PNTSYMPGMPGGISPYPSG-----YP 179
            |.:||.::.|||:|..:.|.....||.|           |..|..|.||   :|||:|     ||
 Worm   131 MAMVFQEKCPVFARSAANSATNASATNPSAGSSASSTPTPYPSSQPTMP---TPYPTGSGAAPYP 192

Human   180 PNPSGYPGC---------------PYPPG----GPYPATTSSQY---PSQPPV---TTVGPSRDG 219
            |:.:.||..               |||.|    .|||:.:|:..   |..|||   |:|..|..|
 Worm   193 PSSTPYPSAGAMGYNPYMNVPQSTPYPMGASGASPYPSASSNPAPPPPRPPPVTAQTSVSSSSGG 257

Human   220 TISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEV 284
            ||..||||||::|||.:|:|.:::|.|....||:.:::.|.::|::|.|||:.|:..|:.:.:.:
 Worm   258 TIQADTIRASVMSAVEEKIRAKLRERMGTNSAEMASIRTTSDELREGQQKLKRMLEELETQRSSL 322

Human   285 DKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEAL 349
            ....|:...|..||:.||.. ...::...|||.|....||::||:..||::...:|.|:.||::|
 Worm   323 QTACEIYTAKKAELAKALSD-AGGTDAPPIDEAIDAAFPLHRQIVLNYAKDLTCDDVIYSLGQSL 386

Human   350 RRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGL 386
            ::..|.|..:|:|||.:||:||..||.|||.|:||||
 Worm   387 KKRQITLAEYLRHVRDVSREQFIYRATMQKCRRTAGL 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSG101	NP_006283.1	UEV	21..139	CDD:399041	56/117 (48%)
		Interaction with CEP55	158..162		2/14 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..220		8/27 (30%)
		DUF1640	<236..292	CDD:400241	15/55 (27%)
		Vps23_core	316..375	CDD:401418	23/58 (40%)
		PTAP motif	320..323		0/2 (0%)
tsg-101	NP_500364.2	UEV	21..139	CDD:283415	56/117 (48%)
		Vps23_core	353..408	CDD:286532	21/54 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161455000
Domainoid	1	1.000	133	1.000	Domainoid score	I3476
eggNOG	1	0.900	-	-		E1_KOG2391
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4584
Inparanoid	1	1.050	284	1.000	Inparanoid score	I1977
Isobase	1	0.950	-	0	Normalized mean entropy	S1648
OMA	1	1.010	-	-		QHG54978
OrthoDB	1	1.010	-	-		D1435538at2759
OrthoFinder	1	1.000	-	-		FOG0001267
OrthoInspector	1	1.000	-	-		oto22719
orthoMCL	1	0.900	-	-		OOG6_102944
Panther	1	1.100	-	-	LDO	PTHR23306
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5678
SonicParanoid	1	1.000	-	-		X3220
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750