Protein Alignment TSC2 and gig

DIOPT Version :9

• Sequence 1: XP_011520940.2
• Gene: TSC2 / 7249
• HGNCID: 12363
• Length: 1879
• Species: Homo sapiens
• Sequence 2: NP_524177.1
• Gene: gig / 40201
• FlyBaseID: FBgn0005198
• Length: 1847
• Species: Drosophila melanogaster
• Alignment Length: 1990
• Identity: 599/1990 - (30%)
• Similarity: 942/1990 - (47%)
• Gaps: 440/1990 - (22%)

Human    97 SKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQICEV--- 158
            |||   |.|||:.|     :..|....|::|   :..|..|||..|..:..|.||:.::.:.
  Fly     3 SKD---KSKFKLFL-----KSLPAGYVGERT---LRPEFERELRPEQPVAQRCRMLKELGDTQLH 56

Human   159 -------------------------AKTKKF----------EEGERLGVLRALFFKVIKDYPSNE 188
                                     |:|::.          .:.:.|.::|..||.||:::.:.|
  Fly    57 NFNLDESAITILFNLTNDLIVPNKPAETRQIALSFYKRLIHTQYKNLTIMREKFFLVIQNHEARE 121

Human   189 DLHERLEVFKALTDNGRHITYLEEELADFVLQWM----DVGLSSEFLLVLVNLVKFNSCYLD-EY 248
            ||...||:...|||||:.||..||::..|:|.|:    :..|.:.:|.:||||:|||:.:|| :.
  Fly   122 DLRHLLELLDTLTDNGKDITNFEEKIGKFMLLWIPAITEANLLTPYLDILVNLIKFNAAHLDKDI 186

Human   249 IARMVQMIC-LLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWK 312
            :..:||..| |.|..|.:.:.:: .|.:|:.|:.|...|:|.||..|.|||||:|....|...:|
  Fly   187 LVGIVQNACDLSCSVTVNEIGLQ-CLTILEMVIGYTIFPSEPLPQCITTLCRTVNHAPYCPSSFK 250

Human   313 LMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSP----TSV 373
            :|:|||||.||:.::..||.::.|||..:||.|||||||.:.|.::|::.::.:  ||    |:|
  Fly   251 IMKNLLGTQLGYHSMKMMCSILNDRALYDDAHLLRGAVFHLNMNIFGSNIIFQV--SPMTYATNV 313

Human   374 LPSFYQAMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDS------- 431
            |.:|.:|:.....:|::|::||:..:|.|  ::|..:.||::.:|:..::..::..:.
  Fly   314 LTAFLRALDSRQVIVTFEVILSVRMVITK--RQLSEIIWDLICDIMSSIVSNIEYYEEVNINKDR 376

Human   432 -PELRTIVHDLLTTVEELC--DQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKD 493
             ..|:...|:.:..:|:|.  |:::..|:.||.::|:||.||:|||:|:|.||.||::.:...:.
  Fly   377 LHHLQINFHENIDCIEKLLQQDRSQILGNVERIYDLIERVADRRPEASVLALIEYRSRRVTATRP 441

Human   494 GWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQV 558
            .|:|.|...:.|::|. |...||||.::.|..::..||..||||:::.||:..||||..:...||
  Fly   442 DWLQVLAQFVRRYYRM-SNVNVRIKTIEALVQIMDQNRACYEEEILSRVVLVHLSHIHLESSVQV 505

Human   559 RKLATQLLVDLAEGCHTHHFNSLLDIIEKVMAR--------SLSPPPELEERDVAAYS--ASLED 613
            |....:.|.:.|..|.|.....||||:|.::.|        |.|....|.|......:  :.:.|
  Fly   506 RVAVARALSNFATHCDTKRCMDLLDILEALINRPFEHTRHGSSSGEGTLAEVTFGLVNNESEISD 570

Human   614 VKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRAD 678
            :..||.||:.:...||:.||..||.:::.:|:.|::|||:........|.:|.:.|.:||..||:
  Fly   571 IIAAVDGLVKVFAIKLHRLPGIHALKIFNILMDHLELHYERPKIFEHISVVRYKIFAWLLKARAN 635

Human   679 SLHRLGLP-NKDGVVRFSPYCVCDYMEPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSL 742
            ..:.:|.| ....||:||||...|             .||.|...|.            ::....
  Fly   636 GSYHIGYPEGSTEVVKFSPYLGID-------------SPLLPQAHPT------------AISIRR 675

Human   743 LFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSAL--CSMLSGPKTLERLR 805
            :.:::::||:.::|::|.:||:..||:.|:.|.|:..:  .:::|.:.|  .:::|..|
  Fly   676 VCKLIVRCLEHDTDYQVFQLVIRELPKVLQNKALVQGN--DIEELANTLLKINLVSNNK------ 732

Human   806 GAPEGFSR-TD-LHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVE 868
                 |.| || .|..|:|.:.:|:.||..|...:...::..|...::...||.|:..::|..:|
  Fly   733 -----FKRPTDEFHALVLPAIASLVIYHESLQPQQHYGIITALNSRVLTGIASVCINTMTILILE 792

Human   869 MPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARL-PHLYRNFAAEQYASVFAISLPYTNP 932
            ||:.:::.||.::::::.:|.|.::|.|:|||||.|..| .||:.||.:.....||||:||||.|
  Fly   793 MPEALMRKLPDVLLQMSKMSDTNALATPVLEFLSLLIHLSKHLFANFTSMHNMYVFAITLPYTKP 857

Human   933 SKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNV------LLSFDDTPEKDSFRARS 991
            .:::.|.|.|||||||.||::|:|..|::.|.:|...::||.      :::.:...|..|.|.||
  Fly   858 HRYDHYTVSLAHHVIAGWFLKCKLELRRNCVNYIKSSIQSNAKMLSSDIVNLNSLNEDSSNRKRS 922

Human   992 TSLNERPKSLRIARPPKQGLNNSPPVKEFKESSAAEAFRCRSISVSEHVVRSRIQTSLTSASLGS 1056
            |||.||            |..|:           |.|:.
  Fly   923 TSLTER------------GSRNN-----------ANAWN-------------------------- 938

Human  1057 ADENSVAQADDSLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLV 1121
             |.....|.::.|:|.|.||.|||.|.:||:.:|...::|||.|..||||..|.::||||||.||
  Fly   939 -DLEMRPQMNNGLRNFHAELAETCFDFLARHTYSPCPSMPKRLPAAEFLLKDGVSQTWLVGNNLV 1002

Human  1122 TVTTSVGTGTRSLLGLDSGELQSG-----PESSSSPGVHV---------------RQTKEAPAKL 1166
            |:|||         |..|...:||     .:...:|.:.:               |:.:.....|
  Fly  1003 TITTS---------GCPSAPARSGLCERCAQLGKAPSISLNSKSLSDAAPPLSPERERRYTKVSL 1058

Human  1167 ESQAGQQVSRGARDRVRSMS------GGHGLR------VGALDVPA-----SQFLGSATSPGPRT 1214
            :..:|.: |.|:.:...|.|      |||..|      ..:||..:     .:.||||...|..|
  Fly  1059 QHSSGNE-SAGSTELTSSSSSNSAAAGGHPHRQISNSSTASLDALSRRGSNPEALGSALGEGAHT 1122

Human  1215 --------------APAAKPEKASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMS 1265
                          :.:..|...|.     ||:...:.|     ..||||:||||||||.||:..
  Fly  1123 GSNTSLLGNSLSQSSVSMSPSSGSV-----VQQPVCVRA-----CTGWAEVLVRRPTGNVSWITR 1177

Human  1266 LENPLS--------PFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAASTAKPPPLP- 1321
            ::||::        || :::.::.|......:...:           .::..|..:.|.|.|.|
  Fly  1178 IQNPITNDCFGQELPF-NNVVSLFLPTAHGGVFGPD-----------NTIQAPPHTLADPEPEPE 1230

Human  1322 --------------RSNTVASFSSLYQSSCQGQLHRSVSWAGIASQREAVGCRAPLCLIDSAVVM 1372
                          ||..||...:|.:   |.::| ||...|..:........||
  Fly  1231 AEVNAATAPQASALRSRMVAKARALQR---QEEIH-SVGGNGNGNGNGNGSGNAP---------- 1281

Human  1373 EEGSPGEVPV-LVEPPGLEDVEAALGMDRRTDAYSRSSSVSSQE--EKSLHAEELVGRG-IPIER 1433
            ..|....:|: .|...|....||||           ..|||..|  :.||..|:...|. .|:.|
  Fly  1282 STGGAAAIPIPRVPASGKRGKEAAL-----------CGSVSDGEADDDSLAFEDAQSRARNPVRR 1335

Human  1434 VVSSEGGRPSVDLSFQPS-----------QPLSKSSSSPE-LQTL-------------------- 1466
            |.||    |.:..|::.|           :|:..::..|: |.||
  Fly  1336 VNSS----PEMSSSWRQSFLTNKPTPLSQEPVKTTADEPQSLLTLKKKTVQYSTKDMRVSCEAIP 1396

Human  1467 QDILGD-PGDKADVGRLSPEVKARSQSGTLD------GESAAWSASGED---------------S 1509
            ::|.|. |..:|....|.||      ||||.      .:.::..|.|.:               |
  Fly  1397 EEIAGSTPPSQAAALALQPE------SGTLPPKQHSADDVSSHVAGGSNLQAGGSTLKLGKPPLS 1455

Human  1510 RGQP------------------EGPLPSSSPRSPSG--------------------LRPRGYTIS 1536
            .|||                  .|.|..||....:|                    :|.|..|||
  Fly  1456 PGQPPLLGTGRVTSFGGTSVPQPGALAKSSSSGSNGTNVGVITSDYDNGNNGNGDMMRGRSKTIS 1520

Human  1537 DSAPSRRGKRVERDALKSRATASNAEKVP-----GINPSFVFLQLYHSPFFGDESNKPILLPNES 1596
            .......|.  .|....|......|.|.|     .:||||:|:|||.:...| .:::|:.:..|:
  Fly  1521 VVREVNNGN--TRPPPASSFRNFGAAKPPINTKLCMNPSFIFMQLYTTGQLG-VTDEPLKVGPEN 1582

Human  1597 QSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQP 1661
            .|   :|.|:|.:|.::||||.|||||:||.|:|:.||.|.|||.||.|||..:|.|:.||:.:.
  Fly  1583 SS---AVSLIDLVPPFETHKIGVLYVGQGQCNNEVEILRNSHGSARYVEFLRNIGTLVSLKEAEQ 1644

Human  1662 DKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRC-DKKRHLGNDFVSIVYNDS 1725
            :.::: .||..|.||:|.|.|.|||:|..||:||||||...|...| :||.|:|||||.|:||:|
  Fly  1645 NNLFI-MLDRNGADGKFAYIWKDDILQVTFHVATLMPTNLQDDPNCNEKKSHIGNDFVKIIYNES 1708

Human  1726 GEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALH 1790
            ||::.|.||.||||:..|||.|||...|.|.::.|.::...|..:..:|||||:.|.:|||||||
  Fly  1709 GEEYNLNTISGQFNYACVIVEPLDLNSNRVYVKARSEISKFVCHAEYRIVSDRSAPLLARQMALH 1773

Human  1791 ANMASQVHHS--RSNPTDIYPSKWIARLRHIKRLRQRICE 1828
            ||:||.|:.|  :.:|   |.|.|:.|||.:||||.::.|
  Fly  1774 ANLASLVYQSVQKKHP---YASNWLERLRKLKRLRSKLIE 1810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSC2	XP_011520940.2	None
gig	NP_524177.1	DUF3384	40..467	CDD:288697	135/432 (31%)
		HEAT repeat	484..515	CDD:293787	11/30 (37%)
		Tuberin	566..882	CDD:281532	108/353 (31%)
		Rap_GAP	1617..1802	CDD:280332	93/188 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144555
Domainoid	1	1.000	251	1.000	Domainoid score	I2111
eggNOG	1	0.900	-	-		E1_KOG3687
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H462
Inparanoid	1	1.050	747	1.000	Inparanoid score	I585
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47539
OrthoDB	1	1.010	-	-		D341431at2759
OrthoFinder	1	1.000	-	-		FOG0005485
OrthoInspector	1	1.000	-	-		oto88903
orthoMCL	1	0.900	-	-		OOG6_104155
Panther	1	1.100	-	-	LDO	PTHR10063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1559
SonicParanoid	1	1.000	-	-		X5077
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800