Protein Alignment TSC2 and tsc2

DIOPT Version :10

• Sequence 1: XP_011520938.1
• Gene: TSC2 / 7249
• HGNCID: 12363
• Length: 1825
• Species: Homo sapiens
• Sequence 2: XP_012825619.2
• Gene: tsc2 / 100170546
• XenbaseID: XB-GENE-981706
• Length: 1808
• Species: Xenopus tropicalis
• Alignment Length: 1855
• Identity: 1238/1855 - (66%)
• Similarity: 1454/1855 - (78%)
• Gaps: 79/1855 - (4%)

Human     1 MAKPTSKDSGLKEKFKILLGLGTPRPNPRSAEGKQTEFIITAEILRELSMECGLNNRIRMIGQIC 65
            |||...||.|||||.|:||||...|...:.:|.|..|::|||::::|||.|..|:.|||.|.|:|
 Frog     1 MAKQMGKDPGLKEKVKMLLGLVPARVKTKPSEWKHPEYVITADLMKELSSESALHVRIRAIIQVC 65

Human    66 EVAKTKKFEEHAVEALWKAVADLLQPERPLEARHAVLALLKAIVQGQGERLGVLRALFFKVIKDY 130
            |:|||||||||||||:.::|.||:|||:|:||||.||.|||||:.|||||||||||.||:|||:|
 Frog    66 ELAKTKKFEEHAVEAICQSVGDLIQPEQPVEARHHVLQLLKAIIVGQGERLGVLRAHFFRVIKEY 130

Human   131 PSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYI 195
            |.||||.||||||||||||||.|.|||||||.||||||::||:.:||.|||||||||||||:.:|
 Frog   131 PMNEDLAERLEVFKALTDNGREIAYLEEELAVFVLQWMEIGLTPDFLHVLVNLVKFNSCYLEHFI 195

Human   196 ARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRTINVKELCEPCWKLM 260
            |.|||||||||.||.|..||||||:||||||||||||:||:|:|::|||||||||||||||||||
 Frog   196 APMVQMICLLCNRTTSPYDIEVSLKVLDAVVCYNCLPSESIPIFVMTLCRTINVKELCEPCWKLM 260

Human   261 RNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGAHRLYSLRNSPTSVLPSFYQ 325
            ||||||||||||||.|..:|||||:||||||||||||||||.|||||||:.|:|||.||||||.:
 Frog   261 RNLLGTHLGHSAIYTMSRIMEDRAHMEDAPLLRGAVFFVGMGLWGAHRLFCLKNSPISVLPSFLK 325

Human   326 AMACPNEVVSYEIVLSITRLIKKYRKELQVVAWDILLNIIERLLQQLQTLDSPELRTIVHDLLTT 390
            ||.|.|.|||||||||:|||||||.|::|...||:||:|||||.||||.|.|.||:..||:|:||
 Frog   326 AMNCNNAVVSYEIVLSVTRLIKKYGKDVQAATWDVLLDIIERLFQQLQVLRSQELKAAVHNLMTT 390

Human   391 VEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQALMERFFRS 455
            .|||.:||.|||.:||:|||||:.||:||.:|::|||:||||||||.|:|||.|||.||:|:|||
 Frog   391 TEELYNQNGFHGDEERFFELVEKGADERPFASVVNLITYRAQSIHPGKEGWIMNLQKLMDRYFRS 455

Human   456 ESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCH 520
            |||..||:|:||||||.|.|||||||:|||..||..||:|||||||||||||||||||||||.||
 Frog   456 ESRSVVRMKILDVLSFALSINRQFYEDELIEKVVTCQLAHIPEDKDHQVRKLATQLLVDLAECCH 520

Human   521 THHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHATR 585
            :.|||||:||||||:.||||.|....:      |:|||||||:||||:||||||||.||||||.|
 Frog   521 SCHFNSLMDIIEKVVNRSLSTPESGHD------SSSLEDVKTSVLGLMVILQTKLYILPASHAMR 579

Human   586 VYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRADSLHRLGLPNKDGVVRFSPYCVCDYM- 649
            |||||::|||||||::|:.|||:|||||.|||||.||||||.|:|||||||..||||||:|:.:
 Frog   580 VYEMLINHIQLHYKYNYSSPIATSIRLQVFDFLLHLRADSLRRVGLPNKDGAFRFSPYCLCESVN 644

Human   650 -EPERGSEKKTSGPLSPPTGPPGPAPAGPAVRLGSVPYSLLFRVLLQCLKQESDWKVLKLVLGRL 713
             :.:|.:|:|.:|.||||:|.|.........|:|.:|:||.|.|:|||||||:|||||||||.:|
 Frog   645 EQEKRAAERKPAGTLSPPSGSPSVPSQTVTPRMGFLPFSLAFGVILQCLKQETDWKVLKLVLNKL 709

Human   714 PESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLRGAPEGFSRTDLHLAVVPVLTALISYHN 778
            ||.||||:||.:|||::|||..:||:||:.....:||...|:|||||||.||||||||||.|||.
 Frog   710 PECLRYKLLILSSPCNIDQLAGSLCAMLTDKTASDRLYITPDGFSRTDLQLAVVPVLTALTSYHQ 774

Human   779 YLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAVPL 843
            :|:.:||||||.|||.|||.||..|||||||:|.:|||.|:||:||||:|||||||||.:||:|:
 Frog   775 HLELSKQREMVRCLETGLIFRCGKQCVVALSMCVIEMPSILIKSLPVLIVKLTHISATVTMAIPM 839

Human   844 LEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDF 908
            |||||||.||||||.||||||||||||||||||||||||||||.|||||||||||||||..|:||
 Frog   840 LEFLSTLVRLPHLYANFAAEQYASVFAISLPYTNPSKFNQYIVFLAHHVIAMWFIRCRLSLRRDF 904

Human   909 VPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNSPPVKEFKESSAAE 973
            ||:|||||||||||||||||||.||||||||||||||||::::..|.|.:::.||||.::.|  .
 Frog   905 VPYITKGLRSNVLLSFDDTPEKGSFRARSTSLNERPKSLKLSKHTKPGFSDTSPVKEMRDLS--N 967

Human   974 AFRCRSISVSEHVVRSRIQTSLTSASLGSADENSVAQADDSLKNLHLELTETCLDMMARYVFSNF 1038
            |||.||||||||...||:|||:||:||.||||:|:||||||||||||||||.||||||||.|:||
 Frog   968 AFRSRSISVSEHAAYSRMQTSVTSSSLSSADESSMAQADDSLKNLHLELTEICLDMMARYAFANF 1032

Human  1039 TAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGELQSGPESSSSPGVHVR 1103
            ||||||||||||||.|||||||||||||||:|||||.|||||||||:|....|...:||| |...
 Frog  1033 TAVPKRSPVGEFLLDGGRTKTWLVGNKLVTITTSVGMGTRSLLGLDTGGENHGDTENSSP-VQTE 1096

Human  1104 QTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGALD-VPASQFLGSATSPGPRTAPAAKPE 1167
            |.||.|:.|:.|..:...:..|.||||||||..||.|:|: .|.|..:|.     |...|..:.|
 Frog  1097 QVKEFPSMLDLQQRKPGMQTPRHRVRSMSGGTTLRAGSLEGTPLSASMGQ-----PGATPVTRAE 1156

Human  1168 KASAGTRVPVQEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELS 1232
            |.|..|::. :|||.||.:||:|||||||:|||||||||||||||||||||||||||||||||||
 Frog  1157 KPSRRTQMK-KEKTTLADFVPVLTQGWAEVLVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELS 1220

Human  1233 NALMAAERFKEHRDTALYKSLSVPAA----STAKPPPLPRSNTVASFSSLYQSSCQGQLHRSVSW 1293
            ||||||||.||||:|||||||||||:    ||.|...|.|:|||||.|.:.|||.||:|.||:||
 Frog  1221 NALMAAERLKEHRETALYKSLSVPASTLSPSTTKCTLLQRANTVASVSLVTQSSGQGKLLRSISW 1285

Human  1294 AGIASQREAVGCRAPLCLIDSAVVMEEG--SPGEVPVLVEPPG---LEDVEAALGMD-------- 1345
            |                  :|..|.|||  :.||...:..|.|   |||.||.:..|
 Frog  1286 A------------------ESCAVPEEGAQADGEAEEVSTPGGSQELEDFEAVVSEDTTSEEKSA 1332

Human  1346 RRTDAYSRSSSVSSQEEK-SLHAEELVGRGIPIERVVSSEGGRPSVDLSFQPSQPLSKSSSSPEL 1409
            ::.:..|||||.|||||. :...||....||||      ||....|     |.|.||||||||||
 Frog  1333 KKMECISRSSSTSSQEESAATQTEESEAGGIPI------EGSTREV-----PFQTLSKSSSSPEL 1386

Human  1410 QTLQDILGDPGDKADVGRLSPEVKA----------RSQSGTLDGESAAWSASGEDSRGQPEGPLP 1464
            ||||::..:.|...|:.:.|.:.|.          |::|.......|.....|| .|.:||  ||
 Frog  1387 QTLQELPKELGPTEDIKKPSADFKTLPHVENPLSHRTKSEEERSAGALAKPEGE-MRLEPE--LP 1448

Human  1465 SSSPRSPSGLRPRGYTISDSAPSRRGKRVERDALKSRATASNAEKVPGINPSFVFLQLYHSPFFG 1529
            ..||:||:|.||||:|||||.|||||:|.:.|..|:...::.|||||||:|||||||||||||||
 Frog  1449 VLSPQSPTGHRPRGHTISDSEPSRRGRRFQVDPFKNSTKSTKAEKVPGIDPSFVFLQLYHSPFFG 1513

Human  1530 DESNKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLT 1594
            ||||||||:|| :|:|||::.|||:||.||||||.||||||||..:|.|||||||||||||:|||
 Frog  1514 DESNKPILVPN-TQTFERTMGLLDRIPPYDTHKIGVLYVGEGQVGNERAILSNEHGSYRYTQFLT 1577

Human  1595 GLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHL 1659
            |||:||||||.||||::|||||.||:||||||||||||||.:|.|.||||.|::|.:||:||||:
 Frog  1578 GLGKLIELKDTQPDKIFLGGLDGCGDDGQFTYCWHDDIMQVIFQITTLMPNKEIDPNRCNKKRHV 1642

Human  1660 GNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDR 1724
            ||:||:|:||||||.:||||:|||||||.|.:.|||.|.|||:|||||||||||||||||||||:
 Frog  1643 GNNFVNIIYNDSGEFYKLGTLKGQFNFVDVNIQPLDCESNLVTLQCRKDMEGLVDTSVAKIVSDK 1707

Human  1725 NLPFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRICEEAAYSNPSLPLVHPP 1789
            ||||:|||||||:|||||||||||||||||||||||||||||::|.:|.||....:.::|...|.
 Frog  1708 NLPFLARQMALHSNMASQVHHSRSNPTDIYPSKWIARLRHIKKMRPKIQEELQELSANMPYQVPT 1772

Human  1790 SHSKAPAQTPAEPTPGYEVGQRKRLISSVEDFTEF 1824
            ..:|.|:|.|..|...:|.|||.||||:|:|||||
 Frog  1773 MANKPPSQNPQTPPGAFETGQRTRLISAVDDFTEF 1807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSC2	XP_011520938.1	DUF3384	54..419	CDD:463376	275/364 (76%)
		Tuberin	555..903	CDD:460965	248/349 (71%)
		Rap_GAP	1580..1766	CDD:460463	151/185 (82%)
tsc2	XP_012825619.2	DUF3384	54..419	CDD:463376	275/364 (76%)
		Tuberin	549..899	CDD:460965	248/349 (71%)
		Rap_GAP	1563..1749	CDD:460463	151/185 (82%)