Protein Alignment TSC1 and hsp-90

DIOPT Version :10

• Sequence 1: NP_000359.1
• Gene: TSC1 / 7248
• HGNCID: 12362
• Length: 1164
• Species: Homo sapiens
• Sequence 2: NP_506626.1
• Gene: hsp-90 / 179971
• WormBaseID: WBGene00000915
• Length: 702
• Species: Caenorhabditis elegans
• Alignment Length: 880
• Identity: 163/880 - (18%)
• Similarity: 300/880 - (34%)
• Gaps: 275/880 - (31%)

Human   209 MKENLETF----------EEVVKPMMEHVRIH-PELVTGSKDHELDPRRWKRLETHDVVIECAKI 262
            |.||.|||          ..::.....:..|: .||::.:.| .||..|::.|
 Worm     1 MSENAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASD-ALDKIRYQAL------------ 52

Human   263 SLDPTEASYEDGYSVSHQISARFPHRSADVTTSPYADTQNSYGCATSTPYSTSRLMLLNMPGQLP 327
             .:|:|  .:.|..:..:|:   |::.....|            ...|....::..|:|..|
 Worm    53 -TEPSE--LDTGKELFIKIT---PNKEEKTLT------------IMDTGIGMTKADLVNNLG--- 96

Human   328 QTLSSPSTRLITEPPQA------------TLWSPSMVCGMTTPPTSPGNVPPDLSHPYSKVFGTT 380
             |::...|:...|..||            ..:|..:|..... .||..|  .|.|:.:.    ::
 Worm    97 -TIAKSGTKAFMEALQAGADISMIGQFGVGFYSAFLVADKVV-VTSKNN--DDDSYQWE----SS 153

Human   381 AGGKGT--PLGTPATSPPPAPLCH-SDDYVHISLPQATVTPPRKEERMDSARPCLHRQH-----H 437
            |||...  |...|..:.....:.| .:|.:..           .|||........|.|.     .
 Worm   154 AGGSFVVRPFNDPEVTRGTKIVMHIKEDQIDF-----------LEERKIKEIVKKHSQFIGYPIK 207

Human   438 LLNDRGSEEPPGSKGSVTLSDLPGFLGDLASEEDSIEKDKEEAAISRELSEITTAEAEPVVPRGG 502
            |:.::..|:....:.:|...|.....|::.:..|..:|.|.:....:...:....:.:|:..|..
 Worm   208 LVVEKEREKEVEDEEAVEAKDEEKKEGEVENVADDADKKKTKKIKEKYFEDEELNKTKPIWTRNP 272

Human   503 FD------SPFYRDSLPGSQRKTHSAASSSQGASVNPEPLHSSLDKLGPDTPKQAFTPIDLPCGS 561
            .|      :.||: || .:..:.|.|..            |.|:
 Worm   273 DDISNEEYAEFYK-SL-SNDWEDHLAVK------------HFSV--------------------- 302

Human   562 ADESPAGDRECQTSLETSIFTPSPCKIPPPTRVGFGSGQPPPYDHLFEVALPKTA------HHFV 620
                     |.|......:|.|                |..|:| |||....|.:      ..|:
 Worm   303 ---------EGQLEFRALLFVP----------------QRAPFD-LFENKKSKNSIKLYVRRVFI 341

Human   621 IRKTEELLKK----AKGNTEEDGVPSTSPMEVLDRLIQQGADAHSKELN--KLPLPSKSVDWTHF 679
            :...|||:.:    .||..:.:.:    |:.:...::||     ||.|.  :..|..|.::..
 Worm   342 MENCEELMPEYLNFIKGVVDSEDL----PLNISREMLQQ-----SKILKVIRKNLVKKCMELI-- 395

Human   680 GGSPPSDEIRTLRDQLLLLHNQLLYERFKRQ-----QHALRNRRLLRKVIK--------AAALEE 731
                  ||:...:|..     :..||:|.:.     .....||:.|...::        ..:|:|
 Worm   396 ------DEVAEDKDNF-----KKFYEQFGKNLKLGIHEDSTNRKKLSDFLRYSTSAGDEPTSLKE 449

Human   732 HNAAMKD-QLKL-----QEKDIQMWKVSLQKEQAR---------------YNQLQE---QRDTMV 772
            :.:.||: |.::     :.||:......:::.::|               ..||:|   ::...|
 Worm   450 YVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQQLKEYDGKKLVSV 514

Human   773 TKLHSQIRQLQHDREEFYNQSQELQTKLEDCRNMIAELRIELKKANNKVCHTELLLSQVSQKLSN 837
            ||...::.:.:.::::|    :|.:...|:...:|.::   |:|...||..:..|:|.....:::
 Worm   515 TKEGLELPETEEEKKKF----EEDKVAYENLCKVIKDI---LEKKVEKVGVSNRLVSSPCCIVTS 572

Human   838 SESVQQQME-FLNRQLLVLGEVNELYLEQLQNKHSDTTKEVEMMKAAYRKELEKNRSHVLQQTQR 901
            .......|| .:..|.|               :.|.|     |...|.:|.||.|..|.:.:|.|
 Worm   573 EYGWSANMERIMKAQAL---------------RDSST-----MGYMAAKKHLEINPDHAIMKTLR 617

Human   902 ----LDTSQKRILELESHLAKKDHLLLEQKKYLEDVKLQARG-QLQAAESRYEAQKRITQVFELE 961
                :|.:.|.:         ||.::|     |.:..|.|.| .|:..:|.   ..||.::.:|.
 Worm   618 DRVEVDKNDKTV---------KDLVVL-----LFETALLASGFSLEEPQSH---ASRIYRMIKLG 665

Human   962 ILDLYGRLEKDGLLKK--LEEEKAEAAEAAEERLD 994
             ||:.....:|..:..  ..|.|.|.||....|::
 Worm   666 -LDIGDDEIEDSAVPSSCTAEAKIEGAEEDASRME 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TSC1	NP_000359.1	Hamartin	7..719	CDD:461287	100/563 (18%)
		Mediates interaction with WDR45B. /evidence=ECO:0000269|PubMed:28561066	403..787		73/443 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..571		18/137 (13%)
		Smc	<708..>960	CDD:440809	55/294 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1006..1085
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1131..1164
hsp-90	NP_506626.1	HSP90	6..702	CDD:481033	160/875 (18%)