Protein Alignment TRPS1 and srp

DIOPT Version :9

• Sequence 1: NP_054831.2
• Gene: TRPS1 / 7227
• HGNCID: 12340
• Length: 1294
• Species: Homo sapiens
• Sequence 2: NP_732100.2
• Gene: srp / 41944
• FlyBaseID: FBgn0003507
• Length: 1264
• Species: Drosophila melanogaster
• Alignment Length: 1326
• Identity: 247/1326 - (18%)
• Similarity: 433/1326 - (32%)
• Gaps: 440/1326 - (33%)

Human   125 AFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGD--SLETKEDQKMSPKATEETGQA-QSGQAN 186
            |..|.||....|.....:..||..|...|...:.:  |||:...|.::...:|...|| .:..|:
  Fly    80 ATGSNAAANETEIAIETENGEAATPTAAATAAAANLSSLESARSQALTSVVSETARQAVTTANAS 144

Human   187 CQGLSPVSVASK-NPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPT 250
            ....|.|:.|:: .....||     ..:.::..::|:|.....:....:.|..        ||.:
  Fly   145 ATSTSTVTAATEIATATASD-----TAATSEAAIDDDPSAINTNNNNNNSKAQ--------NDAS 196

Human   251 DLIK-HFRKYHLGLHNRTRQDAE----------LDSKILALHNMVQFSHSKDFQKVNRSVFSGVL 304
            :.:| ....||.....:.:|..:          |..::::.|...|      .|:..:.....|:
  Fly   197 ESVKTKVISYHQSEDQQQQQQQQAQIYEQQQQFLSQQLISHHQQEQ------HQQAQQQQHQQVV 255

Human   305 QDINSSRPVLLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTY--MGNSSTELEQHF 367
            |:.:.:..:    .||  :|||...............:.      |..|:|  ..::.|:|.:|:
  Fly   256 QEQHQASWL----AYD--LTSGSAAAAAAAAAAASHPHL------FGQFSYPPSHHTPTQLYEHY 308

Human   368 ---------------------------LQTHPNKIKASLPSSEVAKPSEKNSNKSIPALQSSDSG 405
                                       :.:|.:...|:..::.||:.:..|.::.|
  Fly   309 PSTDPIMRNNFAFYSVYTGGGGGVGVGMTSHEHLAAAAAAAAAVAQGTTPNIDEVI--------- 364

Human   406 DLGKWQDKITVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCESSSSLKLLEHYGK 470
                 ||.:..:..:|   |:|.....|       |..:..:..|..|....:...|...:|:.:
  Fly   365 -----QDTLKDECFED---GHSTDYHVL-------TSVSDMHTLKDSSPYALTHEQLHQQQHHHQ 414

Human   471 Q----HGAVQSGGLNPELNDKLSRGSVINQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDN 531
            |    |...|....:.:...:..:....:.|:...|:.|::.
  Fly   415 QQLHHHQQQQQQLYHQQQQQQQQQQHHHHHNNSTSSAGGDSP----------------------- 456

Human   532 MVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITY 596
                          |.||....      |:.:.||.:..:          |...|||
  Fly   457 --------------SSSHALST------LQSFTQLTSATQ----------RDSLSPE-------- 483

Human   597 PFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCHQCSFTTPDVDVLLFHYESVHESQASDVKQEA 661
                   |.::.|...|       |||......:..|..|...:.:.:..:|.:::||
  Fly   484 -------NDAYFAAAQL-------GSSLQNSSVYAGSLLTQTANGIQYGMQSPNQTQA------- 527

Human   662 NHLQGSDGQQSVKESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNT 726
             |||....||..::.::|.      ..|::::..:|:...|..:.    |.:::...:.|.|.::
  Fly   528 -HLQQQHHQQQQQQHQQHQ------QQQLQQQQQQHHHNQHQHHN----SSSSSPGPAGLHHSSS 581

Human   727 VHCQEQDITTANGEEDGHAISTIKE---EPKIDFR---VYNLLTPDSKMGEPVSESVVKREKLEE 785
            .......:..|....:||. |::::   .|:....   ....|....::..|.|.||.:...:..
  Fly   582 SAATAAAVAAATAAVNGHN-SSLEDGYGSPRSSHSGGGGGGTLPAFQRIAYPNSGSVERYAPITN 645

Human   786 KDGLKEKVWTE------SSSDDLRNVTWRGA----DILRGSPSYTQASLGLLTPVSGTQEQTKTL 840
            ..| :...|.:      |||...:.....||    :::|...:.:.|:........||     |.
  Fly   646 YRG-QNDTWFDPLSYATSSSGQAQLGVGVGAGVVSNVIRNGRAISAANAAAAAAADGT-----TG 704

Human   841 RDSPNVEAAHLARPIYGLAVETKG-------FLQGAPAGGEKSGA----LPQQYPASGENKSK-- 892
            |..|....:..| .:..:|.|:.|       |..|   ||.:|.|    ....|...|.|.:.
  Fly   705 RVDPGTFLSASA-SLSAMAAESGGDFYKPNSFNVG---GGGRSKANTSGAASSYSCPGSNATSAA 765

Human   893 ----------------DESQSLLRRRRGS-----GVFCANCLTTKTSLWRKNANGGYVCNACGLY 936
                            ||..|....||.|     |:.|:||.||.|||||:|..|..||||||||
  Fly   766 TSAVASGTAATAATTLDEHVSRANSRRLSASKRAGLSCSNCHTTHTSLWRRNPAGEPVCNACGLY 830

Human   937 QKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRG------------------- 982
            .||||.||||.:.|..     |::|.||   |:..::|:...:.:.
  Fly   831 YKLHSVPRPLTMKKDT-----IQKRKRK---PKGTKSEKSKSKSKNALNAIMESGSLVTNCHNVG 887

Human   983 ----SNEEQVNGS---PLERRSEDHLTESHQREIP-----------------------------L 1011
                |::..||..   .|:.:..:..:...|:::|                             .
  Fly   888 VVLDSSQMDVNDDMKPQLDLKPYNSYSSQPQQQLPQYQQQQQLLMADQHSSAASSPHSMGSTSLS 952

Human  1012 PSLSKYEAQGSLTKSHSAQQPVLVSQTLDI----HKRMQPLHIQIKSPQES-------------- 1058
            ||...::.|   |..|..||..|.| .||:    :.:|.||::|....|:|
  Fly   953 PSAMSHQHQ---THPHQQQQQQLCS-GLDMSPNSNYQMSPLNMQQHQQQQSCSMQHSPSTPTSIF 1013

Human  1059 -TGDP----------GNSSSV-----SEGKGSSERGSP-IEKYMRPAKHPNYSPPGSPIEKYQYP 1106
             |..|          .|:||:     :....|:|..:. |:||::..:..:.|..||..: :|..
  Fly  1014 NTPSPTHQLHNNNNNNNNSSIFNNNNNNNSSSNENNNKLIQKYLQAQQLSSSSNSGSTSD-HQLL 1077

Human  1107 LFGLPFVHNDFQSEA-------------DWLRFWSKYK-------LSVPGNP-------HYLSH- 1143
            ...||   |...:.|             :.|...|:..       |.|...|       ..|||
  Fly  1078 AQLLP---NSITAAAAAAAAAAAAAIKTEALSLTSQANCSTASAGLMVTSTPTTASSTLSSLSHS 1139

Human  1144 -VPGLPNP--------CQNYVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTK 1199
             :..|.||        |:...|.|.:.|.|.
  Fly  1140 NIISLQNPYHQAGMTLCKPTRPSPPYYLTPE---------------------------------- 1170

Human  1200 APPNVKNEGPLNVVKTEKVDRSTQDE 1225
                 ::|.|. ::|.|::|:|.|.:
  Fly  1171 -----EDEQPA-LIKMEEMDQSQQQQ 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPS1	NP_054831.2	ZnF_GATA	904..947	CDD:214648	29/47 (62%)
		ZnF_GATA	908..964	CDD:238123	31/55 (56%)
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	30/53 (57%)
		ZnF_GATA	802..853	CDD:238123	31/55 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141001
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6068
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.780