Protein Alignment TRPS1 and GATAd

DIOPT Version :10

• Sequence 1: NP_054831.2
• Gene: TRPS1 / 7227
• HGNCID: 12340
• Length: 1294
• Species: Homo sapiens
• Sequence 2: NP_609383.2
• Gene: GATAd / 34395
• FlyBaseID: FBgn0032223
• Length: 842
• Species: Drosophila melanogaster
• Alignment Length: 791
• Identity: 163/791 - (20%)
• Similarity: 274/791 - (34%)
• Gaps: 217/791 - (27%)

Human   360 STELEQHFLQTHPNKIK----ASLPSSEVAKPSEKNSNKSIPA--------LQSSDSGDLGKWQD 412
            |.:::...|..|.|:.|    .|:||:..||.||:.....:.:        .:|..|.|    .:
  Fly   104 SQQIQSQTLHHHQNQTKIHYTPSVPSAADAKSSERERQCQLESDIAERSTVFKSQSSSD----HE 164

Human   413 KITVKAGDDTPVG-------YSVPIKPLDS-----SRQNGTEATSYYWCKFCSFSCESSSSLKLL 465
            .|.......:|..       .|.|::..:.     ::|:|.|.||.           :::::...
  Fly   165 HIEYSGETPSPSASLSQSQTKSEPMREEEEHQHNHNQQSGREETSV-----------NTTNISGT 218

Human   466 EHYGKQHGAVQSGGLNPELNDKLSRGSVIN--QND-LAKSSEGETMTKTDKSSSGAKKKDFSSKG 527
            ::|||:||...|.  :|.|..::.....|.  .|| |.....|:...|.|              .
  Fly   219 DNYGKEHGRDDSS--SPHLTFQIFNCLSIKALPNDGLPNVVCGDCRQKLD--------------S 267

Human   528 AEDNMVTSYNCQFC--DF-RYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEK 589
            .|.....::|.|..  :| ..||:..||                            |..|   |.
  Fly   268 FEKFRTMAHNSQIALKEFLNISKNLRPD----------------------------PNDL---ET 301

Human   590 HLGEITYPFACRKSNCSHCALLLLHLSPGAAGSSRVKHQCHQC-SFTTPDVD--------VLLFH 645
            .|..|     .:.|:.:..|..|..||.    .|:||:...:. |...|.:|        .:..|
  Fly   302 KLDAI-----LKASSEAIAAKALTELST----FSKVKYDHSKLDSSIQPGLDRKIEISNQEMPAH 357

Human   646 --YESVHESQASDVKQEANHLQGSDGQQ-SVKESKEHSCTKCDFITQVEE------EISRHYRRA 701
              |.|:.:|......|::..:.||...| ..|..|:....|.:.:.|..|      :||:....:
  Fly   358 SLYPSLFKSITMKSDQKSKAMSGSSHSQFDSKLQKDSDIEKYENLQQQLETAAVLMDISKKIVIS 422

Human   702 HSCYKCRQCSFTAA-DT------------------QSLLEHFNTVHCQEQDITTANGEEDGHAI- 746
            ..|...:...|:|| ||                  |..:|...:|..|:.|.:........|..
  Fly   423 PPCSNPQSPCFSAAVDTSIKSSVIKSKRPSNQNEIQDGVEIDLSVKKQKNDYSNQRNAAPIHHFC 487

Human   747 --------STIKEEPKIDFRVYNLLT-----PDSKMGEPVSESVVKREKLEEKDGLKEKVWTESS 798
                    |.::.|.  ||:.|::..     .|.|...|.:.:....:..:..|..|.::...||
  Fly   488 QTPMLDIQSHLRSEE--DFQNYSITINQVGGSDFKSKAPKASTGSLLDSGDSSDSHKLEMDITSS 550

Human   799 SDDLRNVTWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSP------NVEAAHLARPIYG 857
            .:|.:.     .|.|....:...|:..|...::  :...|:..|:|      |:.:...|.|:..
  Fly   551 INDRKT-----PDSLSSDHATDAATTQLWQALA--RSAAKSKEDNPASQIFRNMMSQPFAFPVPS 608

Human   858 LAVETK---------GFLQGAPAGGEKSGALPQQYP---------------------ASGENKSK 892
            ....||         ..|..|.:...|.....|.:|                     |:.::|..
  Fly   609 TVSFTKVPEEPIALLKDLSEAQSSKSKPCRRKQSFPTKTDCIDVVNENVTDTYTTSEATPDDKKD 673

Human   893 DESQSLLRRRRGS--GVFCANCLTTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGE 955
            ..:.:|.....|:  .:.|:||.|..|::||::..|..||||||||.|||...||
  Fly   674 KRNINLFNAIPGAQKDMSCSNCGTLTTTIWRRSVRGEMVCNACGLYFKLHGVNRP---------- 728

Human   956 QIIRRRT--RKRLNPEALQAEQLNKQQRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYE 1018
            ..:||.|  .:|..|:.|:..:...:|..|      .|.:|...:|.||......|....|:|::
  Fly   729 HSMRRDTIHTRRRRPKELERSKKKHKQMSS------CSSIETTKQDFLTARESLAISGLVLNKFK 787

Human  1019 AQGSLTKSHSA 1029
            .:...|::.:|
  Fly   788 KEIDDTETPAA 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPS1	NP_054831.2	ZnF_GATA	908..964	CDD:238123	24/57 (42%)
GATAd	NP_609383.2	zf-AD	<228..284	CDD:214871	13/71 (18%)
		GAT1	625..>742	CDD:227928	34/126 (27%)
		ZnF_GATA	691..742	CDD:238123	25/60 (42%)