Protein Alignment TRPC6 and trpc6a

DIOPT Version :10

• Sequence 1: NP_004612.2
• Gene: TRPC6 / 7225
• HGNCID: 12338
• Length: 931
• Species: Homo sapiens
• Sequence 2: XP_005161247.1
• Gene: trpc6a / 563989
• ZFINID: ZDB-GENE-040724-114
• Length: 874
• Species: Danio rerio
• Alignment Length: 904
• Identity: 652/904 - (72%)
• Similarity: 736/904 - (81%)
• Gaps: 61/904 - (6%)

Human    24 RRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLRE---KGRRLANRGPA 85
            :||.|:|.|||:...|||        |||.|..:.|         :.|.|:   |.||.|.||.|
Zfish    21 KRNRSKDNLLMNEHFGED--------CYGSYGNYHG---------ENVARQVLPKSRRQAVRGAA 68

Human    86 YMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITE 150
            |||:....||:..|||||||||||||||||:||||...|:||||||||||||||||||||||:||
Zfish    69 YMFNGHPNSLTPLEERFLDAAEYGNIPVVRRMLEELPELDVNCVDYMGQNALQLAVANEHLEVTE 133

Human   151 LLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTR 215
            |||||:||||:||||||||||||.|||||||||.|||:.:||..||||:.: .|||:||||||||
Zfish   134 LLLKKDNLSRIGDALLLAISKGYTRIVEAILSHKAFADSRRLTASPSQAPM-HDDFFAYDEDGTR 197

Human   216 FSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGL 280
            |||||||:|||:||.||||||.||.||||||:||||||.|:.||..||:|||.|||||||||:||
Zfish   198 FSHDVTPVILASHCHEYEIVHILLGKGARIEQPHDYFCTCDTCNYHQKYDSFCHSRSRINAYRGL 262

Human   281 ASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAI 345
            |||||||||:||||:.|||||||||.||||||||||:|:||||||||||||||||||:|||||||
Zfish   263 ASPAYLSLSNEDPVLAALELSNELASLANIEKEFKNEYRKLSMQCKDFVVGLLDLCRSTEEVEAI 327

Human   346 LNGDV-ETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLV 409
            |||:. :||:.  .|||:|.|||||||||:|||||||||||||||||||:|..|||||.|:||||
Zfish   328 LNGEEDDTLEL--PGRPSLIRLKLAIKYELKKFVAHPNCQQQLLSIWYEHLPELRQQTTAIKFLV 390

Human   410 VLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNE 474
            ||.||:||||||::||.||||||||||||||:||||||||||||||||||||||||:|||||||.
Zfish   391 VLGVAMGLPFLAMVYWVAPCSKMGKIMRGPFLKFVAHAASFTIFLGLLVMNAADRFDGTKLLPNM 455

Human   475 TSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAA 539
            |..|...|||||||:.|:||||||||||||||||||||||:|||:|||.|.||:|||||||||.|
Zfish   456 TIHDYPTQLFRMKTTPFTWMEMLIISWVIGMIWAECKEIWSQGPREYLLEPWNLLDFGMLAIFVA 520

Human   540 SFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVV 604
            |||:|.|||||||.||..:|.:.|  |||.|.|...|.|:..|||.|.|||||::||||||||||
Zfish   521 SFISRIMAFWHASSAQRYVDEHYT--DLTNVVLPFEVGYFQRARIDWLPSDPQLVSEGLYAIAVV 583

Human   605 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFT 669
            ||||||||||||||||||||||||||||||||||||||:||:|||||||||||||.|||||||||
Zfish   584 LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFILVFLAFMIGMFNLYSYYRGAKQNEAFT 648

Human   670 TVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEI 734
            |||||||||||||||||||||||:|..||||||||||||||||||:|||||||||||||:|||||
Zfish   649 TVEESFKTLFWAIFGLSEVKSVVVNNGHKFIENIGYVLYGVYNVTVVIVLLNMLIAMINNSFQEI 713

Human   735 EDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDA 799
            |||||||||||||||||:||||||||||||||:|||||:..|::.:|..:.|| ...:|...:.:
Zfish   714 EDDADVEWKFARAKLWFTYFEEGRTLPVPFNLIPSPKSVLSLVMGVKGLLREL-SVRQKAIMKGS 777

Human   800 EMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIK 864
            |::::.:.|              :...|.:.       |||             :||||||||:|
Zfish   778 ELSELGQSK--------------TCQAKTLP-------RSS-------------RYQKIMKRLVK 808

Human   865 RYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSME 923
            ||:::||.|||.|||||||||||||||||||||||||||.|.|:||:|:|.|.:.||.:
Zfish   809 RYIIKAQNDKECDEVNEGELKEIKQDISSLRYELLEEKSHNMEELAKLVRTLEKNLSQD 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPC6	NP_004612.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		0/1 (0%)
		trp	82..897	CDD:273311	614/815 (75%)
		ANK 1	97..126		22/28 (79%)
		ANK 2	132..161		26/28 (93%)
		ANK repeat	132..159	CDD:293786	24/26 (92%)
		ANK repeat	161..185	CDD:293786	21/23 (91%)
		ANK 3	163..189		23/25 (92%)
		ANK repeat	212..247	CDD:293786	29/34 (85%)
		ANK 4	218..247		23/28 (82%)
trpc6a	XP_005161247.1	TRPV	65..841	CDD:454755	614/815 (75%)
		ANK repeat	76..113	CDD:293786	27/36 (75%)
		ANK repeat	115..146	CDD:293786	27/30 (90%)
		ANK repeat	194..228	CDD:293786	28/33 (85%)