DRSC/TRiP Functional Genomics Resources

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Protein Alignment TRPC6 and trp

DIOPT Version :10

Sequence 1:NP_004612.2 Gene:TRPC6 / 7225 HGNCID:12338 Length:931 Species:Homo sapiens
Sequence 2:NP_476768.1 Gene:trp / 43542 FlyBaseID:FBgn0003861 Length:1275 Species:Drosophila melanogaster


Alignment Length:924 Identity:298/924 - (32%)
Similarity:450/924 - (48%) Gaps:205/924 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    95 LSIEEERFLDAAEYGNIPVVRKMLEE---CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKE 156
            ||..|:.|:.:.|.|::|.|:|:|||   ....|:||.|.|.::||..|:.||:.::..:||  |
  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILL--E 91

Human   157 NLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVT 221
            :...||||||.|||:.||..||.:|..          ...:..|.|...:.|.|...:.|:.|:|
  Fly    92 HNIEVGDALLHAISEEYVEAVEELLQW----------EETNHKEGQPYSWEAVDRSKSTFTVDIT 146

Human   222 PIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYL 286
            |:|||||...|||:..||.:||.:..|||..|.|::|...|..||..||:||||||:.|::.:.:
  Fly   147 PLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLI 211

Human   287 SLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVE 351
            :|||.|||:||.:||.||..|..:|.||:.:|.::....:||...|||..|.:.|:|.:||.:.|
  Fly   212 ALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHE 276

Human   352 TLQSGDHG------RPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVV 410
            .    .|.      |..|.||||||:|:.|.||||||.||.|.:|||:.|.|.|::..:.:.:.|
  Fly   277 P----SHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDV 337

Human   411 LAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAAD------RFEGTK 469
            :.:....|..:|.|..||.|:..|.||.||:||:.|:.|:..|  |:::.||.      .||   
  Fly   338 VKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFF--LMLLGAASLRVVQITFE--- 397

Human   470 LLPNETSTDNAKQLFRMKTSCFSWM-------------------EMLIISWVIGMIWAECKEIWT 515
            ||                  .|.||                   |:.||::::.:|:.|.|.:::
  Fly   398 LL------------------AFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYS 444

Human   516 QGPKEYLFELWNMLDFGMLAIFAASFIARFMAF-------WHASKAQSIIDANDTLKDLTKVTLG 573
            .|..||:.:|||::|:.....:....:.|..|:       |...     ||              
  Fly   445 DGLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRG-----ID-------------- 490

Human   574 DNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFM 638
               .|:  .|..|.|.||.::|||.:|..:|.|:.::.:|...|...||||:||||.:.||.||.
  Fly   491 ---PYF--PREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFF 550

Human   639 VIFIMVFVAFMIGMFNLYSYYIGAKQNEA----------------------FTTVEESFKTLFWA 681
            .|:.:|..||..|:..|..||...::|:.                      |:.:.|:.::||||
  Fly   551 FIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWA 615

Human   682 IFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFAR 746
            .|||.::.|..:.....|......:::|.|:|..:||||||||||:::|:|.|.:.||.||||||
  Fly   616 SFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFAR 680

Human   747 AKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLG 811
            ::||.||||:|.|:|.||||.|:.|.|                                 .|.||
  Fly   681 SQLWMSYFEDGGTIPPPFNLCPNMKML---------------------------------RKTLG 712

Human   812 ILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKES 876
                                .|:||  .::.|...|.......:.|:||.|::||:...|..::.
  Fly   713 --------------------RKRPS--RTKSFMRKSMERAQTLHDKVMKLLVRRYITAEQRRRDD 755

Human   877 DEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIR----------------------ELG-- 917
            ..:.|.::.|::|||||||:||||..:.|..|:.::.:                      ::|  
  Fly   756 YGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFV 820

Human   918 EKLSMEPNQEETNR 931
            |.|..|.::.|:.|
  Fly   821 ENLKQEMSESESGR 834

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRPC6NP_004612.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
trp 82..897 CDD:273311 286/864 (33%)
ANK 1 97..126 10/31 (32%)
ANK 2 132..161 9/28 (32%)
ANK repeat 132..159 CDD:293786 9/26 (35%)
ANK repeat 161..185 CDD:293786 14/23 (61%)
ANK 3 163..189 12/25 (48%)
ANK repeat 212..247 CDD:293786 16/34 (47%)
ANK 4 218..247 15/28 (54%)
trpNP_476768.1 trp 16..776 CDD:273311 286/864 (33%)
ANK repeat 69..98 CDD:293786 10/30 (33%)
ANK repeat 99..135 CDD:293786 14/45 (31%)
ANK repeat 137..168 CDD:293786 14/30 (47%)
TRP_CaM_bind1 797..860 CDD:467881 6/38 (16%)
PRK12323 <891..1102 CDD:481241
PspC_subgroup_2 <1015..1156 CDD:468202
Blue background indicates that the domain is not in the aligned region.

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