DRSC/TRiP Functional Genomics Resources

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Protein Alignment TRPC6 and Trpgamma

DIOPT Version :10

Sequence 1:NP_004612.2 Gene:TRPC6 / 7225 HGNCID:12338 Length:931 Species:Homo sapiens
Sequence 2:NP_001137830.2 Gene:Trpgamma / 34991 FlyBaseID:FBgn0032593 Length:1188 Species:Drosophila melanogaster


Alignment Length:880 Identity:328/880 - (37%)
Similarity:490/880 - (55%) Gaps:137/880 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    74 EKGRRLANRGPAYMFSDRST--------SLSIEEERFLDAAEYGNIPVVRKMLEECHS---LNVN 127
            |..||:.......|..:.:|        .|::||::||.|.|.|::...|:||::...   :|||
  Fly    49 EPARRVKRHSIHGMMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVN 113

Human   128 CVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSH---PAFAEG 189
            |||.:|:.||.:|:.||:||:.|||:.....::  ||||.:||:.:|..||.:|.|   ...:||
  Fly   114 CVDPLGRTALLMAIDNENLEMVELLINYNVDTK--DALLHSISEEFVEAVEVLLDHENVTFHSEG 176

Human   190 KRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCK 254
            .....|.|             ||.:.|:.|:||:|||||...|||:..||.:||.:..|||..|.
  Fly   177 NHSWESAS-------------EDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCG 228

Human   255 CNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYK 319
            |::|.|.::.||..|||||||||:.||||:.::|||:||::||.|||.||..|:.:|.||||:|:
  Fly   229 CDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQ 293

Human   320 KLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHG-RPNLSRLKLAIKYEVKKFVAHPNC 383
            :|..||:||...|||..|.:.|:|.:||.| .|....:|| |.:|:|||||||...||||||.|.
  Fly   294 ELRKQCQDFATALLDHTRTSHELEILLNHD-PTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNV 357

Human   384 QQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAA 448
            ||.|.|||||.|.|.|::.||::.:.::.:.|..|..:|.|..||.|.:|:.||.||:||:.|:|
  Fly   358 QQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSA 422

Human   449 SFTIFLGLLVMNAADRFE----GTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAE 509
            |:..||.||:: |:.|.|    |.....:....:..::|...:.:..:::|.||::||.|:||:|
  Fly   423 SYFTFLFLLML-ASQRIETFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWSE 486

Human   510 CKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGD 574
            .|::|..|.:|||.::||::||...:::.|:...|.::|:...| :.|.:::.|           
  Fly   487 VKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQK-EMIYNSHAT----------- 539

Human   575 NVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMV 639
                 :|.|.:||..||.:|||||::.|.:.|..::.||...|...||||:||.|.|.||.||..
  Fly   540 -----DLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFF 599

Human   640 IFIMVFVAFMIGMFNLYSYYIGAKQNEA--------------------------FTTVEESFKTL 678
            ::::|..||..|:..|..||...::...                          |:.:.|:.:||
  Fly   600 LYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQTL 664

Human   679 FWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWK 743
            |||:|||.::.|..::....|....|.:::|.|:|..::||||:||||:|.|:|.|.:.||||||
  Fly   665 FWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADVEWK 729

Human   744 FARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELF--------QGHKKGFQEDAE 800
            |||:|||.||||||.|.|.|||::|:|||::|.:    ||:..:|        :.|.|..:..|:
  Fly   730 FARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAI----KWMRRVFCSGSSAARREHLKTIRRKAQ 790

Human   801 MNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKR 865
            .                                    .|..||          :||:||:.|::|
  Fly   791 Q------------------------------------ASDRDF----------KYQQIMRNLVRR 809

Human   866 YVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE 900
            ||...|...||..|.|.::.|||||||:.|.||:|
  Fly   810 YVTVEQRKAESQGVTEDDVNEIKQDISAFRCELVE 844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRPC6NP_004612.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
trp 82..897 CDD:273311 322/867 (37%)
ANK 1 97..126 10/31 (32%)
ANK 2 132..161 11/28 (39%)
ANK repeat 132..159 CDD:293786 11/26 (42%)
ANK repeat 161..185 CDD:293786 11/26 (42%)
ANK 3 163..189 11/28 (39%)
ANK repeat 212..247 CDD:293786 17/34 (50%)
ANK 4 218..247 15/28 (54%)
TrpgammaNP_001137830.2 trp 77..841 CDD:273311 320/847 (38%)
ANK repeat 118..147 CDD:293786 11/30 (37%)
ANK repeat 175..217 CDD:293786 20/54 (37%)
TRP_CaM_bind1 865..>891 CDD:467881
Blue background indicates that the domain is not in the aligned region.

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