Protein Alignment TRPC6 and Trpc6

DIOPT Version :10

• Sequence 1: NP_004612.2
• Gene: TRPC6 / 7225
• HGNCID: 12338
• Length: 931
• Species: Homo sapiens
• Sequence 2: XP_006509912.1
• Gene: Trpc6 / 22068
• MGIID: 109523
• Length: 949
• Species: Mus musculus
• Alignment Length: 931
• Identity: 871/931 - (93%)
• Similarity: 893/931 - (95%)
• Gaps: 1/931 - (0%)

Human     1 MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLA 65
            |||||.|..|||.|.:.|.||..|||||||||||| |||:||.||.|||.|||||.|||::|||.
Mouse    20 MSQSPRFVTRRGGSLKAAPGAGTRRNESQDYLLMD-ELGDDGYPQLPLPPYGYYPSFRGNENRLT 83

Human    66 HRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVD 130
            |||||:|||||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||
Mouse    84 HRRQTILREKGRRLANRGPAYMFNDHSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVD 148

Human   131 YMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATS 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||
Mouse   149 YMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATS 213

Human   196 PSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQ 260
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.:|:|
Mouse   214 PSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQ 278

Human   261 KQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQC 325
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
Mouse   279 KQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQC 343

Human   326 KDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSI 390
            ||||||||||||||||||||||||.||.|.||.||||||||||||||||||||||||||||||||
Mouse   344 KDFVVGLLDLCRNTEEVEAILNGDAETRQPGDFGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSI 408

Human   391 WYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLG 455
            |||||||||||||||||||||||||||||||||||.|||||||||:|||||||||||||||||||
Mouse   409 WYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLG 473

Human   456 LLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKE 520
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
Mouse   474 LLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKE 538

Human   521 YLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIK 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   539 YLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIK 603

Human   586 WDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMI 650
            |||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   604 WDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMI 668

Human   651 GMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTM 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   669 GMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTM 733

Human   716 VIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL 780
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||.
Mouse   734 VIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKF 798

Human   781 KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHL 845
            |||:.||.||.|:||||||||||.|||||.||.||||||||.||||.|:.||||.|.|||||:||
Mouse   799 KKWMCELIQGQKQGFQEDAEMNKRNEEKKFGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHL 863

Human   846 NSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLA 910
            |||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   864 NSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLA 928

Human   911 ELIRELGEKLSMEPNQEETNR 931
            ||||:|||:||:||..||:.|
Mouse   929 ELIRKLGERLSLEPKLEESRR 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPC6	NP_004612.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		14/24 (58%)
		trp	82..897	CDD:273311	781/814 (96%)
		ANK 1	97..126		28/28 (100%)
		ANK 2	132..161		28/28 (100%)
		ANK repeat	132..159	CDD:293786	26/26 (100%)
		ANK repeat	161..185	CDD:293786	22/23 (96%)
		ANK 3	163..189		24/25 (96%)
		ANK repeat	212..247	CDD:293786	34/34 (100%)
		ANK 4	218..247		28/28 (100%)
Trpc6	XP_006509912.1	TRPV	100..915	CDD:454755	781/814 (96%)
		ANK repeat	150..177	CDD:293786	26/26 (100%)
		ANK repeat	179..203	CDD:293786	22/23 (96%)
		ANK repeat	230..265	CDD:293786	34/34 (100%)