DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TRPC6 and trp-1

DIOPT Version :10

Sequence 1:NP_004612.2 Gene:TRPC6 / 7225 HGNCID:12338 Length:931 Species:Homo sapiens
Sequence 2:NP_001367402.1 Gene:trp-1 / 176202 WormBaseID:WBGene00006614 Length:1031 Species:Caenorhabditis elegans


Alignment Length:901 Identity:326/901 - (36%)
Similarity:491/901 - (54%) Gaps:147/901 - (16%)


- Green bases have known domain annotations that are detailed below.


Human    71 VLREKGRR---------------LAN-RGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLE 119
            :|...|||               ||| ..||.:....:..:|.||.|||:|||.||.|.    |:
 Worm    10 MLSAAGRRFSRCAPSPRPRRNYALANIPPPAAVHIRTNDMISPEERRFLEAAELGNKPT----LQ 70

Human   120 EC------HSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVE 178
            ||      ..|||||:|.||:.||::||.||::|:.||||::.:: |:|:|||.||.:|..|:||
 Worm    71 ECLDYDGDRRLNVNCLDSMGRTALEIAVDNENMEVVELLLQQPDI-RIGNALLCAIREGVYRLVE 134

Human   179 AILSHP-----AFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTL 238
            .:::||     ...:|...|..||::.            ...:|.|::|:||||...::||:..|
 Worm   135 VLVNHPNITREMLGDGWSQALDPSEAA------------SAEYSSDISPVILAAQLNQFEILQML 187

Human   239 LRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNE 303
            :||.|.||:||.:.|.|..|::::.:||..:|..|||.::.|||||::||:|.||:::|.:||.:
 Worm   188 IRKDASIEKPHRHSCICETCDRERLNDSLQYSLKRINTFRALASPAWMSLTSPDPILSAFKLSWD 252

Human   304 LAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDH-----GRPNL 363
            |..||..|.|||..|.:||.|||.:...||..||::|||.||||.|...  :.|:     .:.:|
 Worm   253 LQRLAFEEHEFKETYLQLSEQCKQYSCDLLSQCRSSEEVIAILNKDGNV--NDDNIDVWASKLSL 315

Human   364 SRLKLAIKYEVKKFVAHPNCQQQLLSIWYENL-----SGLRQQTMAVKFLVVLAVAIGLPFLALI 423
            ||||||||||.|.||:||:|||.|.|||||.:     ||.........||:.|     .|...|:
 Worm   316 SRLKLAIKYEQKAFVSHPHCQQLLTSIWYEGIPYRQRSGTWANFFLYAFLLFL-----WPIFCLM 375

Human   424 YWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAAD--RFEGTKLLPNETSTDNAKQLFRM 486
            |...|.|::|:::|.|||||..::.||..|||||.....:  |:|..:......::|.....   
 Worm   376 YILMPKSRLGRLVRSPFMKFFYYSVSFATFLGLLTWATFEDYRYEKGERGGMTRASDRGPPA--- 437

Human   487 KTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHA 551
                 :|:|.|:.:|||||:|:|.|::|.:|.|.|:.:.||.|||.|:.::..:...|..|::..
 Worm   438 -----TWVESLVFTWVIGMLWSEIKQLWEEGFKRYMRQWWNWLDFLMICLYLCTISIRLSAYYIF 497

Human   552 SKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPA 616
            :..:                  |..:|  ..|..|...:|.:::|.|:|:..|.||:||.|:...
 Worm   498 TYRE------------------DPYRY--TVRTYWTSEEPMLVAEALFAVGNVFSFARIIYLFQT 542

Human   617 NESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY--------IGA---KQNEAFTT 670
            |...||||||||..:.|:.||..||:::..:|.||:..||.||        .||   ..:..|::
 Worm   543 NPYLGPLQISLGCMLVDVAKFCFIFVLIISSFSIGLAQLYWYYDPNTDVCLPGATCKHSSNVFSS 607

Human   671 VEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIE 735
            :.:|:.||.|::|.:::.:...:..|||..:.:|..::.:|:.|.:||||||||||::.|||.|.
 Worm   608 IADSYLTLLWSLFSITKPEDTDVVENHKITQWVGQGMFIMYHCTSIIVLLNMLIAMMSHSFQIIN 672

Human   736 DDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYL---LLKLKKWISELFQGHKK---- 793
            |.||:||||.|.|||.::|:||.:||.|||::.:||||.|:   |....:|:...:...|.    
 Worm   673 DHADLEWKFHRTKLWMAHFDEGSSLPPPFNIIVTPKSLIYVMNCLFNTVRWLLGKYTYQKNRNRA 737

Human   794 GFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKI 858
            ..:......|.||.:|   .|.|:|                .|::             |..|..|
 Worm   738 TIRRPGYSRKRNEMEK---SGGHDD----------------DSLK-------------PLTYADI 770

Human   859 MKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIR 914
            :.||:.|::.|.:.|.:.|.|||.:|.|||||||||||||.:::.:      |::|
 Worm   771 ITRLVARFIHQTKKDMKMDGVNEDDLHEIKQDISSLRYELRDDRRR------EIVR 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRPC6NP_004612.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
trp 82..897 CDD:273311 314/855 (37%)
ANK 1 97..126 15/34 (44%)
ANK 2 132..161 13/28 (46%)
ANK repeat 132..159 CDD:293786 13/26 (50%)
ANK repeat 161..185 CDD:293786 12/28 (43%)
ANK 3 163..189 11/30 (37%)
ANK repeat 212..247 CDD:293786 14/34 (41%)
ANK 4 218..247 13/28 (46%)
trp-1NP_001367402.1 TRPV 38..809 CDD:454755 314/854 (37%)
ANK repeat 89..119 CDD:293786 14/30 (47%)
ANK repeat 149..195 CDD:293786 17/57 (30%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.