Protein Alignment TRPC5 and YVC1

DIOPT Version :10

• Sequence 1: NP_036603.1
• Gene: TRPC5 / 7224
• HGNCID: 12337
• Length: 973
• Species: Homo sapiens
• Sequence 2: NP_014730.2
• Gene: YVC1 / 854255
• SGDID: S000005613
• Length: 675
• Species: Saccharomyces cerevisiae
• Alignment Length: 729
• Identity: 146/729 - (20%)
• Similarity: 260/729 - (35%)
• Gaps: 205/729 - (28%)

Human   144 TPIMLAAHTNNYEIIKLLVQKRVTIP-RPHQIRCNCVECVSSSEVDSLRH--------SRSRLNI 199
            ||..:...|.|   :|.|:.|.|.|. .|:.|.|:..| :.|.:|..|.:        .::....
Yeast    31 TPRQILRVTLN---LKYLIDKVVPIVYDPNDIVCDHSE-ILSPKVVKLAYEACGGNPKDKANKRK 91

Human   200 YKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQ--CKLFAKDLLDQARSS 262
            |:::...||:.:.....||...          :|.|....|...|:.|  ||     ||.:...:
Yeast    92 YQSVIIFSLLKVCEWYSILATM----------EVHNAKLYETRNLASQQLCK-----LLIEREET 141

Human   263 RELEI----------ILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYD 317
            |:|:.          ::|..|:..|.|:        .|::|...|....:.....|:.|..:|
Yeast   142 RDLQFLFMQLLLRRYVINENDEDQEPLN--------ALELATDMHCTTVIGSSGFQRCLKWIW-- 196

Human   318 GFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLL 382
                   :.|:|:.....|.......|:...|||..:.:.|  |.|..:      :||..:|..|
Yeast   197 -------RGWIVQNGLDPTTFIKDDSLAEVSLISHFNPVRL--KAPVYQ------NYLQMIFSFL 246

Human   383 LA-----------SQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIH-DWW 435
            ..           |:.:...||         :|.:...:..|||..|:.:::   :..|.| .:|
Yeast   247 FLGLYTLVVNGKDSERVQSFDL---------LESIFYVFNTGFILDELTKLY---YIGYAHLSFW 299

Human   436 NLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWE-MWHPTLIAEALFAISNILSSLRLISLFTA 499
            ||.:.....:....:..:.::....|.....|:|: :.:..|...|.|..|      ||:....:
Yeast   300 NLFNDTTYLIITFAMGFRAMSVTPLNAKYSSEDWDKISYRVLSCAAPFVWS------RLLLYLES 358

Human   500 NSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNA 564
            ...:|.:.:.|..|:.:.:.|.|:..|:::.|..|...|......|.|..|
Yeast   359 QRFIGIMLVILKHMMKESIVFFFLLFLIMIGFTQGFLGLDSADGKRDITGP-------------- 409

Human   565 FSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF----VGATMFGTYNVISLVVLLNMLIAMMN 625
                          :.|.|.:.|..:.:...|.||    .....:|.|.::| |:|||:|||:.:
Yeast   410 --------------ILGNLTITVLGLGSFDVFEEFAPPYAAILYYGYYFIVS-VILLNILIALYS 459

Human   626 NSYQLIADHADIEWKFARTKLWMSYF---DEG----------GTLPPPFNIIPSPKS-------- 669
            .:||.:.|:||.|:....::..:.|.   ||.          ..:.|.|.|:|..::
Yeast   460 TAYQKVIDNADDEYMALMSQKTLRYIRAPDEDVYVSPLNLIEVFMTPIFRILPPKRAKDLSYTVM 524

Human   670 ------FLYLGN----------WFNNTFCPKR--------------------DPDG---RRRRRN 695
                  ||.|.:          .:|..   ||                    |.||   ..|...
Yeast   525 TIVYSPFLLLISVKETREARRIKYNRM---KRLNDDANEYDTPWDLTDGYLDDDDGLFSDNRNSG 586

Human   696 LRSFTERNADSL-IQNQHYQEVIR-NLVKRYVAAMIRNSKTHE-----------GLTEENFKELK 747
            :|:...:|:.|| :|....||.:. .:.|::...:.:.|.:.|           |..::..|||.
Yeast   587 MRATQLKNSRSLKLQRTAEQEDVHFKVPKKWYKNVKKCSPSFEQYDNDDTEDDAGEDKDEVKELT 651

Human   748 QDISSFRYEVLDLL 761
            :.:.:....:.|||
Yeast   652 KKVENLTAVITDLL 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPC5	NP_036603.1	trp	17..756	CDD:273311	143/722 (20%)
		ANK 1. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX	30..60
		ANK repeat	35..67	CDD:293786
		ANK repeat	69..98	CDD:293786
		ANK 2. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX	69..97
		ANK 3. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX	98..124
		ANK 4. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX	141..170		9/26 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	766..794
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	810..837
		Essential for binding to NHERF1 PDZ domain. /evidence=ECO:0000250|UniProtKB:Q9QX29	971..973
YVC1	NP_014730.2	Ion_trans	235..470	CDD:459842	57/287 (20%)