DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TRPC5 and trp

DIOPT Version :9

Sequence 1:	NP_036603.1	Gene:	TRPC5 / 7224	HGNCID:	12337	Length:	973	Species:	Homo sapiens
Sequence 2:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster

Alignment Length:	1061	Identity:	395/1061 - (37%)
Similarity:	579/1061 - (54%)	Gaps:	170/1061 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    17 RIPLQIVRAETE-LSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIEN 80
            |:...::.||.. ||..||.|:.:.|:||...||:.|:|.:.....||||.||:.||||:.||||
  Fly    16 RLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIEN 80

Human    81 ENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTL--MMDTQFSEFTPDI 143
            ||.::|.:||.|::.||||||:||.:|.|.|||.||.:...:.::..|..  .:|...|.||.||
  Fly    81 ENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAVDRSKSTFTVDI 145

Human   144 TPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSL 208
            ||::||||.|||||:|:|:.:..|:|.||.::|.|.|||:|...||||||:||:|.|:||::.||
  Fly   146 TPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSL 210

Human   209 IALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRD 273
            |||||.||:||||:|.||||.|..:|:||:|||.|:.|..:.|...|||.||:|.|||::||...
  Fly   211 IALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNH 275

Human   274 DHSEELDPQKYHD---------LAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVV 329
            :.|        ||         |.:||:||:|.||.|||.||.|||||.:||||.||:|||....
  Fly   276 EPS--------HDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQ 332

Human   330 KLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDL- 393
            :|:..:.:|..||:.|:.|:::|.|....|::|||:|||.|:.||:.||.:|..||..:|:...
  Fly   333 QLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFE 397

Human   394 ----------------HVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAM 442
                            |.:|..|..:|..|:.:::..|:.|:|.::..|..|||.|.||::|:..
  Fly   398 LLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYIS 462

Human   443 NSLYLATISLKIVAYVKYNGSR---------PREEWEMWHPTLIAEALFAISNILSSLRLISLFT 498
            |..|:..|..:..|:|..:...         |||.|..:.|.|::|..||...:.|.|:|:.:|:
  Fly   463 NMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFS 527

Human   499 ANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIR-----C 558
            .|.||||||:|||||::||:||.|||.|||.||..|||||.:||   |..|.|.|..:.     .
  Fly   528 INPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYY---AELEKNKCYHLHPDVADF 589

Human   559 EKQNNA------FSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLL 617
            :.|..|      ||.||||.|||||:.|||::|...::.....||.|....|||:|:||:::|||
  Fly   590 DDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLL 654

Human   618 NMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFC 682
            |||||||:||||:|::.||.||||||::||||||::|||:|||||:.|:.|..
  Fly   655 NMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKML------------ 707

Human   683 PKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELK 747
              |...||:|....:||..::.:. .|..| .:|::.||:||:.|..|....: |:||::..|::
  Fly   708 --RKTLGRKRPSRTKSFMRKSMER-AQTLH-DKVMKLLVRRYITAEQRRRDDY-GITEDDIIEVR 767

Human   748 QDISSFRYEVLDLLGN-------------------------RKHPRSFSTSSTELSQRDDNNDGS 787
            |||||.|:|:|::..|                         |:..:.|.....|..:::.:...|
  Fly   768 QDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQEMSESES 832

Human   788 GGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSS-------GAQGKSKAESSSKRSFMGPSLKKL 845
            |  |....|::..:| :|||..|......:.|.:       |:: :|..:..|:||.....:::.
  Fly   833 G--RDIFSSLAKVIG-RKKTQKGDKDWNAIARKNTFASDPIGSK-RSSMQRHSQRSLRRKIIEQA 893

Human   846 --GLLFS-----KFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSE 903
              ||..:     :||.::.:.:....                :.|.:..:.|..|        .|
  Fly   894 NEGLQMNQTQLIEFNPNLGDVTRATR----------------VAYVKFMRKKMAA--------DE 934

Human   904 VELGEVQGA--AQSSECPLACSSSLHCASSICSSN----------SKLLDSSEDVFE-------- 948
            |.|.:.:||  .:..:.||..|.|   ..||.|..          :.|..|.::|.|
  Fly   935 VSLADDEGAPNGEGEKKPLDASGS---KKSITSGGTGGGASMLAAAALRASVKNVDEKSGADGKP 996

Human   949 -TWGEACDLLMHKWGDGQEEQ 968
             |.|:..|  ..|.||.:::|
  Fly   997 GTMGKPTD--DKKAGDDKDKQ 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRPC5	NP_036603.1	trp	17..756	CDD:273311	344/787 (44%)
		ANK 1	31..60		10/28 (36%)
		ANK repeat	35..67	CDD:293786	12/31 (39%)
		ANK repeat	69..98	CDD:293786	15/28 (54%)
		ANK 2	69..97		14/27 (52%)
		ANK 3	98..124		13/25 (52%)
		ANK 4	141..170		16/28 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..794		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	810..837		6/33 (18%)
		Essential for binding to SLC9A3R1 PDZ domain. /evidence=ECO:0000250\|UniProtKB:Q9QX29	971..973
trp	NP_476768.1	trp	16..776	CDD:273311	344/787 (44%)
		ANK	64..>168	CDD:238125	53/103 (51%)
		ANK repeat	69..98	CDD:293786	15/28 (54%)
		ANK repeat	99..135	CDD:293786	13/35 (37%)
		ANK repeat	137..168	CDD:293786	18/30 (60%)
		TRP_2	178..236	CDD:285535	37/57 (65%)
		BASP1	938..1158	CDD:283191	20/83 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148015
Domainoid	1	1.000	275	1.000	Domainoid score	I1760
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824310at2759
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm8466
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.750