DRSC/TRiP Functional Genomics Resources

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Protein Alignment TRPC5 and trp-2

DIOPT Version :10

Sequence 1:NP_036603.1 Gene:TRPC5 / 7224 HGNCID:12337 Length:973 Species:Homo sapiens
Sequence 2:NP_001022703.1 Gene:trp-2 / 192056 WormBaseID:WBGene00006615 Length:886 Species:Caenorhabditis elegans


Alignment Length:895 Identity:377/895 - (42%)
Similarity:533/895 - (59%) Gaps:100/895 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    16 DRIPLQIVRAETELS-AEEKAFLNAVEKGDYATVKQALQ--EAEIYYNVNINCMDPLGRSALLIA 77
            |.:...:...|::.| ..||.||.:.|:||..:|::.|.  ..|.:   ||||:|||||:|||||
 Worm    16 DDVSNNVTWTESDNSRLREKQFLLSCERGDIGSVRKLLAGISTETF---NINCLDPLGRNALLIA 77

Human    78 IENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRP----SGEKQVPTLMMDTQFSE 138
            |||||:|::||||:|::..|||:||||.:|.|.|||:::.:...    ..|:|...:   |:.|.
 Worm    78 IENENIEMIELLLDHNIETGDAILYAIGEENVEAVEIIVEHLEKMDKFDSERQGVEI---TEHSA 139

Human   139 FTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKAL 203
            ||||||||:||||.:|||.|||.:.|:.|:|.||.:||:|.||..:.|.||||.||||:|.|:||
 Worm   140 FTPDITPIVLAAHKDNYECIKLFLDKKGTVPHPHDVRCSCPECYVAREEDSLRLSRSRINAYRAL 204

Human   204 ASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEII 268
            .|||||.||:.||||.||.|.||||.||.:||||:.:||||||:|:.|...:|||.|.|:|||::
 Worm   205 TSPSLICLSARDPILYAFELSWELKRLSFIENEFRTDYEELSQKCQKFCVHMLDQVRGSKELEVV 269

Human   269 LNHRDDHSEELDPQKY---HDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVK 330
            |||..:...::....|   ..||:||:||:..||.|||.|||||||..:||:|....|..:::.|
 Worm   270 LNHTTNAWHDVTSANYGNPEKLARLKLAIQLSQKRFVAHPNCQQLLLDIWYEGVESVRCTNFIYK 334

Human   331 LLTCMTIGFL-FPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQ------HI 388
            |:..: :|.| ||:.|:.||::|.|::|.|.|||||||:.|:.||:.||.:|::|||      :|
 Worm   335 LIFYI-LGMLSFPLFSLVYLLAPHSSMGQFAKKPFIKFLSHSGSYIFFLILLIMASQRMNVIDNI 398

Human   389 VRTD----LHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLAT 449
            :|||    ...:|||||::|..|..||||.||.|||::|:.|...|..:.||::||..|||||.|
 Worm   399 LRTDDVDRKETRGPPPTIIECAIFLWVLGLIWVEIKQLWECGLYNYCRNLWNILDFITNSLYLCT 463

Human   450 ISLKIVAYVKYNGSR------------PREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSH 502
            .:|::||||:.....            ||.:|:.|.|||::|..||.:||.|||:|:.:||.:.|
 Worm   464 TALRVVAYVQVEQEALRANSVHIARHLPRRDWDAWDPTLLSECFFATANIFSSLKLVHIFTVSPH 528

Human   503 LGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPN------NCKGI----- 556
            ||||:||||||::||:||..:|.|||.|||.|||||.:||.:...:|.|      |.|.:     
 Worm   529 LGPLKISLGRMVIDIVKFFMVYALVLFAFACGLNQLLWYYASMRQNECNLYEQYKNEKSLSYKYE 593

Human   557 ----RCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLL 617
                .|:.:..:.|:::.|.::|||::|||::|....:|..|..:|:.|.|:||:|...|::|||
 Worm   594 HLKESCDDKYKSCSSIYHTAETLFWALFGLVDLTHFRLKEDHFLSEWTGKTIFGSYCCCSIIVLL 658

Human   618 NMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFC 682
            |||||||:||||.|:|.|||||||||::|::.|||:..||||||||:|||||..|..::.....|
 Worm   659 NMLIAMMSNSYQYISDQADIEWKFARSRLFLEYFDDTATLPPPFNIVPSPKSIYYCLHYLTKKLC 723

Human   683 -------PKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVK-RYVAAMIRN-SKTHEGL 738
                   |.:....|...:||          .|:.:..:::..|..| ||..|...: :|....:
 Worm   724 NCTKLQQPSKQKSMRVESKNL----------AIRQRPRKQLPENCAKNRYSGAQFHSRNKKKTAM 778

Human   739 TEENFKELKQDISSF-----------RYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARA 792
            .|...|.....:..|           ...:..:..|.:...||..||::||.  .|........:
 Worm   779 AERRLKNSALLLKEFPVPQMFKAGQRNMSISSIQSNGRLKPSFMPSSSKLSW--SNLKVKASRLS 841

Human   793 KSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSL 842
            ||||:.        |.|     ..:.|......||..:..:..||...||
 Worm   842 KSKSID--------TTH-----LDVTRLHALSKKSPLQKQAHTSFDTSSL 878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRPC5NP_036603.1 trp 17..756 CDD:273311 355/806 (44%)
ANK 1. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 30..60 11/32 (34%)
ANK repeat 35..67 CDD:293786 12/33 (36%)
ANK repeat 69..98 CDD:293786 19/28 (68%)
ANK 2. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 69..97 19/27 (70%)
ANK 3. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 98..124 11/29 (38%)
ANK 4. /evidence=ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX 141..170 18/28 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 766..794 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 810..837 3/26 (12%)
Essential for binding to NHERF1 PDZ domain. /evidence=ECO:0000250|UniProtKB:Q9QX29 971..973
trp-2NP_001022703.1 TRPV 34..757 CDD:454755 344/739 (47%)
ANK repeat 69..96 CDD:293786 19/26 (73%)
Blue background indicates that the domain is not in the aligned region.

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