DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TRPC4 and trp

DIOPT Version :9

Sequence 1:	NP_003297.1	Gene:	TRPC4 / 7223	HGNCID:	12336	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster

Alignment Length:	947	Identity:	380/947 - (40%)
Similarity:	546/947 - (57%)	Gaps:	148/947 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    17 RIPLRIVRAESE-LSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIEN 80
            |:...::.||.. ||..||.::.:.|:||...|||.|||.:...|.||||.||:.|:||:.||||
  Fly    16 RLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIEN 80

Human    81 ENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLL-----NHK--KPSGEKQVPPILLDKQFSE 138
            ||.:|:.:||..|:.|||||||||.:|.|.|||.||     |||  :|...:.|     |:..|.
  Fly    81 ENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAV-----DRSKST 140

Human   139 FTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKAL 203
            ||.||||:|||||.|||||:|:|:.:|.::|.||:|:|.|.|||:|...||||||:||:|.|:||
  Fly   141 FTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRAL 205

Human   204 ASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEII 268
            ::.|||||||.||.||||||||||:.|..:|:||::||.|:.:..:.|...|||..|:|.|||::
  Fly   206 SASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVM 270

Human   269 LNYRDDNS-----LIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAV 328
            ||:..:.|     |.:.|:   |.||||||:|:||.|||.||.|||||:.|||..||:||:..:.
  Fly   271 LNFNHEPSHDIWCLGQRQT---LERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQ 332

Human   329 KMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDL- 392
            :::....:|..||::|:.|::||.|....|:||||:|||.|:.||:.||.||..||..:.:...
  Fly   333 QLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFE 397

Human   393 ----------------NRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVM 441
                            :.:|..|..:|..|:.:::..|:.|:|.::..||.:||.|.||::|::.
  Fly   398 LLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYIS 462

Human   442 NSLYLATISLKIVAFV------KYSALN---PRESWDMWHPTLVAEALFAIANIFSSLRLISLFT 497
            |..|:..|..:..|:|      .:..::   |||.|..:.|.|::|..||...:||.|:|:.:|:
  Fly   463 NMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFS 527

Human   498 ANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIR-----CEKQ 557
            .|.||||||:|||||::||:||.|||.|||.||..|||||.:||.|.:...|..:.     .:.|
  Fly   528 INPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQ 592

Human   558 NNA------FSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNML 616
            ..|      ||.||||.|||||:.|||::|...::.....||.|....|||:|:||:::||||||
  Fly   593 EKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNML 657

Human   617 IAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKK 681
            ||||:||||:|::.||.||||||::|||||||:|||:|.|||:.|:.|.|            :|.
  Fly   658 IAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKML------------RKT 710

Human   682 MRRKPESFGTIGVRTQH--RRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKEL 744
            :.||..|      ||:.  |::.:..:..|  .:||:.||:||:.|..| .:.:.|:||::..|:
  Fly   711 LGRKRPS------RTKSFMRKSMERAQTLH--DKVMKLLVRRYITAEQR-RRDDYGITEDDIIEV 766

Human   745 KQDISSFRFEVL------------------GLLRGSKLSTIQS-----------ANASKESSNSA 780
            :|||||.|||:|                  |:.|.:|...::.           .|..:|.|.|.
  Fly   767 RQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQEMSESE 831

Human   781 D---------------SDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVV 830
            .               ..:|.|.:.|:..:|..|:           |..|.|:|.::...|
  Fly   832 SGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFA-----------SDPIGSKRSSMQRHS---- 881

Human   831 QEPPREKQRKVNFVTDIKNFGLFHRRSKQNAAEQNAN 867
               .|..:||   :.:..|.||  :.::....|.|.|
  Fly   882 ---QRSLRRK---IIEQANEGL--QMNQTQLIEFNPN 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRPC4	NP_003297.1	trp	17..754	CDD:273311	351/788 (45%)
		ANK 1	31..60		11/28 (39%)
		ANK 2	69..97		13/27 (48%)
		Multimerization domain. /evidence=ECO:0000250	87..172		46/91 (51%)
		ANK repeat	122..167	CDD:293786	22/44 (50%)
		Multimerization domain. /evidence=ECO:0000250	254..304		26/54 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..795		7/53 (13%)
		PDZ-binding domain	980..982
trp	NP_476768.1	trp	16..776	CDD:273311	351/788 (45%)
		ANK	64..>168	CDD:238125	58/108 (54%)
		ANK repeat	69..98	CDD:293786	14/28 (50%)
		ANK repeat	99..135	CDD:293786	18/40 (45%)
		ANK repeat	137..168	CDD:293786	19/30 (63%)
		TRP_2	178..236	CDD:285535	38/57 (67%)
		BASP1	938..1158	CDD:283191
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148013
Domainoid	1	1.000	275	1.000	Domainoid score	I1760
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824310at2759
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm8466
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.750