Protein Alignment TRPC4 and Trpgamma

DIOPT Version :10

• Sequence 1: NP_003297.1
• Gene: TRPC4 / 7223
• HGNCID: 12336
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Alignment Length: 901
• Identity: 427/901 - (47%)
• Similarity: 578/901 - (64%)
• Gaps: 114/901 - (12%)

Human    28 ELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSF 92
            :|:..||.:|.|||:||.|..::.|::|:....||:||:|||||||||:||:|||||::|||:::
  Fly    77 QLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINY 141

Human    93 NVYVGDALLHAIRKEVVGAVELLLNHK--------KPSGEKQVPPILLDKQFSEFTPDITPIILA 149
            ||...|||||:|.:|.|.|||:||:|:        ..|.|.      ..:..|.|||||||:|||
  Fly   142 NVDTKDALLHSISEEFVEAVEVLLDHENVTFHSEGNHSWES------ASEDTSTFTPDITPLILA 200

Human   150 AHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSE 214
            ||.:||||||:|:.:|..:|.||:|||.|.|||.|...|||||||||:|.|:||||||||||||:
  Fly   201 AHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSK 265

Human   215 DPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIE 279
            ||.||||:|||||:.||.:|:|||:||:||.:||:.||..|||.||:|.||||:||:.....:.|
  Fly   266 DPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTGPVYE 330

Human   280 EQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFS 344
            ......|.|||||||.|||:|||..|.||||||.||:..||:||::.|::.|....||::||:||
  Fly   331 HGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFS 395

Human   345 VCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHI----------DRSDL------- 392
            :.|::||.|.:|..:||||||||||:|||.||||||:||||.|          |.|.:
  Fly   396 LAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEEL 460

Human   393 -NRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF 456
             .::|..||.:||:||.||.|.||.|:||:||.|||:|::|.||::|||.||||:||::|::|:|
  Fly   461 PTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSF 525

Human   457 VK---------YSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRM 512
            .:         ::...|||.||.|.|.|::|.||:.|||||||:|:.:|:.|.||||||:||.||
  Fly   526 FQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRM 590

Human   513 LLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCK---------GIRCEKQNNA------FS 562
            ::||:||.|:|.|||.||.:|||||.:||.:.:...|.         .:......||      ||
  Fly   591 VMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFS 655

Human   563 TLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLI 627
            .||||.|:|||::||||:|....:.....||.|.|..|||||:||::|||||:||||||:|||||
  Fly   656 NLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLI 720

Human   628 ADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTI 692
            ::.||:||||||:|||:||||||||.|.|||:||:|||:||.|||:....|......:.|...||
  Fly   721 SERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSSAARREHLKTI 785

Human   693 GVRTQHRRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLG 757
              |.:.::|:|   |..:||::|||||:|||....|.|:: :|:||::..|:|||||:||.|::.
  Fly   786 --RRKAQQASD---RDFKYQQIMRNLVRRYVTVEQRKAES-QGVTEDDVNEIKQDISAFRCELVE 844

Human   758 LLRGSKLSTIQSANASKESSNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNI 822
            :|:.|.:.|..:|.              ....|..|:::|...|.....:..|.
  Fly   845 ILKNSGMDTNVTAG--------------QGGGGGKKNRQKERRLMKGFNIAPPG----------- 884

Human   823 SNGSALVVQEPPREKQRKVNFVTDIKNF-----------------GLFHRRSKQNA 861
            |.||...|.|          |.|.:.|:                 ...|:|.:..|
  Fly   885 STGSLAPVAE----------FSTSLDNYDNQHEILSSTLSTLFTPNFMHKRQQSQA 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPC4	NP_003297.1	trp	17..754	CDD:273311	406/775 (52%)
		ANK 1. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN	29..60		12/30 (40%)
		ANK 2. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN	71..93		15/21 (71%)
		ANK 3. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN	96..118		13/21 (62%)
		ANK repeat	122..167	CDD:293786	23/44 (52%)
		ANK 4. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM, ECO:0007744|PDB:8WPN	141..165		17/23 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	767..795		3/27 (11%)
		PDZ-binding domain. /evidence=ECO:0000269|PubMed:12154080	980..982
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	406/775 (52%)
		ANK repeat	118..147	CDD:293786	19/28 (68%)
		ANK repeat	175..217	CDD:293786	22/47 (47%)
		TRP_CaM_bind1	865..>891	CDD:467881	7/36 (19%)