DRSC/TRiP Functional Genomics Resources

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Protein Alignment TRPC1 and trpl

DIOPT Version :10

Sequence 1:NP_001238774.1 Gene:TRPC1 / 7220 HGNCID:12333 Length:793 Species:Homo sapiens
Sequence 2:NP_476895.1 Gene:trpl / 36003 FlyBaseID:FBgn0005614 Length:1124 Species:Drosophila melanogaster


Alignment Length:816 Identity:300/816 - (36%)
Similarity:464/816 - (56%) Gaps:85/816 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    12 SGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEEN-SSGDL 75
            :|.||.   .|.:||:|..|........:.:...|.||.||||.::||...|::||::. ....:
  Fly     9 TGVSSG---VSHASSAPKSVGGCCVPLGLPQPLLLEEKKFLLAVERGDMPNVRRILQKALRHQHI 70

Human    76 NINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRP 140
            ||||:|.|||.|:|:.|:||||::::||:..|.::.||||.||::|.|.||::||.|      ..
  Fly    71 NINCMDPLGRRALTLAIDNENLEMVELLVVMGVETKDALLHAINAEFVEAVELLLEH------EE 129

Human   141 TIVKLMERI--QNPEYSTTM---DVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSA 200
            .|.|..|..  |..:.:|.|   |:.|::||||:||:|||.:||.:..::|.||.:.|.|..|..
  Fly   130 LIYKEGEPYSWQKVDINTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVR 194

Human   201 KNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQC 265
            ...:||||||..|::|||.|.||:||.||..|||:.||:||.:|:.|:|.|.|.:::|.:|.|||
  Fly   195 LTAEDSLRHSLSRVNIYRALCSPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQC 259

Human   266 KMFAKDLLAQARNSRELEVILNH---TSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNC 327
            :.||.|||.|.|.|.||.:|||:   .||.||.|       ||:|:||..||.|.||:||:.||.
  Fly   260 QKFAVDLLDQTRTSNELAIILNYDPQMSSYEPGD-------RMSLTRLVQAISYKQKKFVAHSNI 317

Human   328 QQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGA 392
            ||.|:::|:..:.|:|||....|::.:..|.:.:|:..|.|:.||..:.|:::..|||||:||.:
  Fly   318 QQLLSSIWYDGLPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHAS 382

Human   393 SYFTFLLLLNLYSLVYNED----------KK-------NTMGPALERIDYLLILWIIGMIWSDIK 440
            ||..||.:|.|.|...::|          ||       ...|....:::.::::::||.:|.:::
  Fly   383 SYLFFLFILILVSQRADDDFVRIFGTTRMKKELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQ 447

Human   441 RLWYEGLEDFLEESRNQLSFVMNSLYLATFALKV---------VAHNKFHDFADRKDWDAFHPTL 496
            .::..|::.:|....|.:.|:.||||::...|:.         :|.:....:..|:.|..|.|.|
  Fly   448 EIFAVGMKSYLRNMWNFIDFLRNSLYVSVMCLRAFAYIQQATEIARDPQMAYIPREKWHDFDPQL 512

Human   497 VAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQL--Y 559
            :||||||.|||.|.|:|..:::.:..|||||||:|:|:.|..||..::.||||:|..||.||  |
  Fly   513 IAEGLFAAANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWY 577

Human   560 DKGYTSKEQKDCV------------GIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFS 612
               :.:.|:..|.            |..|.:...  |.:...:..:|||..|.:..:..|  ..|
  Fly   578 ---FAALEKSKCYVLPGGEADWGSHGDSCMKWRR--FGNLFESSQSLFWASFGMVGLDDF--ELS 635

Human   613 YGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCT 677
            ..:....|.|.::.|:|:|:.||||..||:||:..|:.:|..|.|.||||||.|||:|||:|..|
  Fly   636 GIKSYTRFWGLLMFGSYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSAT 700

Human   678 LPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRY 742
            ||||||::||.|.:..:....||.|....|| |.|.|....|           |..:|..||.||
  Fly   701 LPPPFNVLPSVKWVIRIFRKSSKTIDRQRSK-KRKEQEQFSE-----------YDNIMRSLVWRY 753

Human   743 LTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDL 778
            :.:|.:|.:: :..:.:::||::.:::..|.|:.::
  Fly   754 VAAMHRKFEN-NPVSEDDINEVKSEINTMRYEMLEI 788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRPC1NP_001238774.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 7/17 (41%)
ANK 1. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM 46..75 12/29 (41%)
TRPV 48..774 CDD:454755 290/774 (37%)
ANK 2. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM 83..109 13/25 (52%)
ANK 3. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM 111..156 17/46 (37%)
ANK 4. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM 158..180 13/24 (54%)
trplNP_476895.1 TRPV 48..784 CDD:454755 285/768 (37%)
ANK repeat 78..114 CDD:293786 18/35 (51%)
ANK repeat 134..177 CDD:293786 17/42 (40%)
TRP_CaM_bind1 798..883 CDD:467881
PHA03247 <961..1069 CDD:223021
Blue background indicates that the domain is not in the aligned region.

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