DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C4B and Tep1

DIOPT Version :9

Sequence 1:	NP_001002029.3	Gene:	C4B / 721	HGNCID:	1324	Length:	1744	Species:	Homo sapiens
Sequence 2:	NP_523578.1	Gene:	Tep1 / 34937	FlyBaseID:	FBgn0041183	Length:	1354	Species:	Drosophila melanogaster

Alignment Length:	1675	Identity:	373/1675 - (22%)
Similarity:	629/1675 - (37%)	Gaps:	414/1675 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     3 LLWGLIWASSFF---TLSLQKPRLLLFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRN 64
            :|| ||.:|:..   .||.......:.:|..:......:|.|.:.:..|...|  ||.|..||.|
  Fly     1 MLW-LILSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTRTTEV--SVSLTGPSLN 62

Human    65 N---------VPCSPKVDFTLSSERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDS 120
            :         ...|.:.|....:|.|:       .||...|.|:       |.|
  Fly    63 SRKYVDVQSMSSKSVRFDIPKLTEGDY-------ELKVMGSGGI-------EFQ----------- 102

Human   121 LSRTTNIQGINLLFSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMVENSHG-- 183
                   ....|.|:.....|::|:|:..|.||.::::||..||:..||:.....:.:|...|
  Fly   103 -------NSTKLSFAPDLNWLYIQSDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQ 160

Human   184 -LRVRKKEVYMPSSIFQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITP 247
             |....|::.....::..:..:.|....|.|.::|...|  |...:....|.|||:|.|||.:..
  Fly   161 NLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTATVQD--EGKVTNVLVVDKYVVPKFEVVVLT 223

Human   248 GKPYILTVPGHLDEMQLDIQARYIYGKPVQG--VAYVRFGLLDEDGKKTFFRGLESQTKLVNGQS 310
            .|    .|......::..|:|||.:.|||:|  ||.:       :|..|      .|:..::|:.
  Fly   224 AK----NVAASAGYIRATIKARYTFKKPVKGHVVATI-------EGSST------EQSLPIDGEV 271

Human   311 HISLSKAEFQDALEKLNMGIT-DLQGLR----LYVAAAIIESPGGEMEEAELTSWYFVSSPFSLD 370
            ::....:.....|.|:...:| :|..::    .||.   :.....::|:   ..|
  Fly   272 NVEFPISATAKRLLKITAIVTEELTDIKHNGTAYVT---VHQHRHKLED---LFW---------- 320

Human   371 LSKTKRHLVPGAPFLLQALVREMSGSPASGIPVKVSATVSSPGSVPEVQDIQQNTDGSGQVSIP- 434
                ..|..||.....:.:||.:.|||.......|:..|.       ...:.:|...|.|.||.
  Fly   321 ----PTHYRPGVSSEFKTVVRNLDGSPVMDSSKMVNFNVL-------CCQVSKNFSASLQNSIAT 374

Human   435 --IIIPQTISELQLSVSAGSPHPAIARLTVAAPPSGGPGFLSIERP-----DSRPPRVGDTLNLN 492
              |::|:|.... |..|.......|.|.           ...:.:|     :::.|::...|.:|
  Fly   375 EHIMLPETCQSC-LVTSTFDTAENIERY-----------IYKLNKPLMIAINTKKPQLRKLLKIN 427

Human   493 LRAVGSGATFSHYYYM-ILSRGQIV---FMNREPKRTLTSVSVFVDHHLAPSFYFVAFYYHGDHP 553
            :    ...|:..|:.: :::||.||   |...:.|:....:.......|.|.......|......
  Fly   428 I----ISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYIIDGVL 488

Human   554 VANSLRVDVQAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKP 618
            :::...||::.. .|..:|:........|  :.|.|.::|:..:.|.|..:|.::...  :|...
  Fly   489 MSDEKTVDIERD-FENTIEILTTNEALPR--DEVSLKVKTNPHSFVGLLGVDQSVLLL--RSGND 548

Human   619 LNMGKVFEAMNSYDLGCGPGGGDSALQVFQAAGLAFSDGDQWTLSRKRLSCPKEKTTRKKRNVNF 683
            ||...:...:.:|         .:.|.:...|                             |:|.
  Fly   549 LNRDLILNNLATY---------STDLVILTNA-----------------------------NINI 575

Human   684 QKAINEKLGQYASPTAKRCCQDGVTRLPMMRSCEQRAARVQQPDCREPFLSCCQFAESLRKKSRD 748
            .::..   |.|.:|        |.|                  :|....:....|.....|.|..
  Fly   576 YRSSG---GCYTNP--------GYT------------------NCTGSLIGRTMFKNEPTKNSGP 611

Human   749 KGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVET---VDRFQILTLWLPDSLTTWEIHG 810
            ....|..||...|.          |||..|||.||:...|   .:...|:...:||:||:|.|.|
  Fly   612 VPIVGSTRAQASLP----------PVRKLFPETWLFSNITDVGANGEYIIKETVPDTLTSWVITG 666

Human   811 LSLSKTKGLCVA-TPVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVEG 874
            .|||...||.|. .|.::|||:.|.:...||.||:|.|.:.:..:::|||..::...|.:...:|
  Fly   667 FSLSPQSGLAVTRNPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDG 731

Human   875 LC------------LAGGGGLAQQVLVPAGSARPVAFSVVPTAATAVSLKVVARGSFEFPVGDAV 927
            ..            ...|....:.:.:||.:.|.::|.:.|......:||:.|...:   .||.:
  Fly   732 QYEFIETTNKNVSQYLRGVRRKKTLWIPANTGRGISFMIRPKKVGLTTLKITAISKY---AGDRL 793

Human   928 SKVLQIEKEGA---IHREEL--VYELNPLDHRGRTLEIPGNSDPNMIPDGDFNSYVRVTASDPLD 987
            .::|::|.:|.   :::..|  |..||     .|:|..|..:  .:|...|  :.:..:.:...:
  Fly   794 HQILKVEADGVQKYVNKAVLINVQRLN-----RRSLAPPEKT--IIIEKAD--NVIEGSETVEFE 849

Human   988 TLGSEGALSPGGVASLLRLPRGCGEQTMIYLAPTLAASRYLD-KTEQWSTLPPETKDHAVDLIQK 1051
            ..|:..|.....:..|:.||.|||||.|....|::.|..||. |..|    ..|.::.|...::.
  Fly   850 VCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQ----DQEIENKAKRYVET 910

Human  1052 GYMRIQQFRKADGSYAAWLSRGS--STWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQAD 1114
            ||.....:::.|||::||....:  ||||||:|::....|.:.:......|....::|:|:|..|
  Fly   911 GYQIELNYKRNDGSFSAWGQHDALGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTD 975

Human  1115 GSFQDLSPVIHRSMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKASSFL 1179
            |.|::|..|||.|       :...:|||:||.      |..|::|...|..:.|   |.:|..|:
  Fly   976 GKFKELGMVIHNS-------HGSPLALTSFVL------LTFFENEEYMPKYKHV---IDRAVEFV 1024

Human  1180 GEKASAGLLGAHAA------AITAYALTLTKAPADLRGVAHNNLMAMAQETGDNLYWGSVTGSQS 1238
                   :...|.:      ||.|.||:|.:.....:.:  :.|..:|...||:.:|   |||..
  Fly  1025 -------VTEVHQSNEPYDLAIAALALSLARNRNAYKVL--DKLDKLATRRGDHKWW---TGSDK 1077

Human  1239 NAVSPTPAPRNPSDPMPQAPALWIETTAYALLHLLLHEGKAEMADQ---AAAWLTRQGSFQGGFR 1300
            ...|.                  :|||:|.||.||.|    .::|:   ...||..:.:..|||.
  Fly  1078 CKSSE------------------VETTSYVLLALLEH----NISDEPKPIVDWLISKRNSNGGFV 1120

Human  1301 STQDTVIALDALSAYWIASHTTEER------GLNVT---LSSTGRNGFK--SHALQLNNRQIRGL 1354
            |:||||:.:.||:.|.:.||.:.|.      .||..   :..|..|.||  :|.|..|..:::.|
  Fly  1121 SSQDTVVGIMALTKYELQSHASTEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLL 1185

Human  1355 EEELQFSLGSKINVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYTMEANEDYED 1419
            .:               |..:..:::...|||.                      |.||...:
  Fly  1186 AK---------------GQGRAQVQLTYRYNVA----------------------TKEARPSF-- 1211

Human  1420 YEYDELPAKDDPDAPLQPVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVC-----IWRNGKVG 1479
                                             :....|.:..:.|:...:|     |..:.:..
  Fly  1212 ---------------------------------KLTTTVKKSHKGRLILGICGTYTPIAASERNK 1243

Human  1480 LSGMAIADVTLLSGFHALRADLE---KLTSLSDRYVSHFET--EGPHVLLYFDSV-PTSRECVGF 1538
            .:.||:..|.|.||:   ..|:|   .:.::||  |...||  |...|.:||:.: |..|:|:..
  Fly  1244 TTNMALMQVQLPSGY---VCDIEPFADIEAISD--VKRVETKNEDTEVHIYFEKLSPGDRKCLTL 1303

Human  1539 EAVQEVPVGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVC 1588
            ||:....|..::|:...|||||..||..:.||...:.   |..:|....|
  Fly  1304 EAIYTHAVANLKPSWVRLYDYYATERSATEFYHVDTS---LCDICHGNEC 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C4B	NP_001002029.3	A2M_N	141..233	CDD:280081	22/94 (23%)
		A2M_N_2	478..610	CDD:285005	26/140 (19%)
		ANATO	686..750	CDD:237984	9/63 (14%)
		A2M	782..869	CDD:278630	32/90 (36%)
		complement_C3_C4_C5	996..1315	CDD:239226	95/330 (29%)
		A2M_comp	1051..1317	CDD:284982	79/276 (29%)
		A2M_recep	1481..1570	CDD:284981	31/94 (33%)
		NTR_complement_C4	1588..1742	CDD:239639	1/1 (100%)
Tep1	NP_523578.1	A2M_N	116..201	CDD:280081	21/86 (24%)
		A2M_N_2	411..542	CDD:285005	25/137 (18%)
		A2M	634..726	CDD:278630	32/91 (35%)
		A2M_2	859..1135	CDD:239227	95/329 (29%)
		A2M_comp	910..1135	CDD:284982	78/274 (28%)
		A2M_recep	1245..1335	CDD:284981	31/94 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149978
Domainoid	1	1.000	53	1.000	Domainoid score	I11337
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810