DRSC - DRSC Integrative Ortholog Prediction Tool

Protein Alignment TRIO and trio

Sequence 1:	NP_009049.2	Gene:	TRIO / 7204	HGNCID:	12303	Length:	3097	Species:	Homo sapiens
Sequence 2:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster

Alignment Length:	27	Identity:	6/27 - (22%)
Similarity:	13/27 - (48%)	Gaps:	0/27 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    11 ISVMFEFLEYSLEHQLPNFSECWWDHW 37
            |..:.:.|.....:.:|...:|.||::
  Fly    64 IEQLIQVLSLRKRNIMPILKDCRWDYY 90

Gene	Sequence	Domain	Region	External ID	Identity
TRIO	NP_009049.2	SEC14	69..204	CDD:214706
		SPEC	230..445	CDD:238103
		Spectrin 1	311..418
		SPEC	341..566	CDD:238103
		Spectrin 2	538..644
		SPEC	567..783	CDD:238103
		SPEC	787..1014	CDD:238103
		Spectrin 3	878..984
		SPEC	908..1137	CDD:238103
		Spectrin 4	1109..1216
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1601..1650
		SH3_Kalirin_1	1659..1718	CDD:212786
		SH3-RhoG_link	1715..1972	CDD:465196
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1779..1906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1927..1965
		RhoGEF	1970..2143	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2287..2552
		PHA03247	<2330..2540	CDD:223021
		SH3_Kalirin_2	2555..2613	CDD:212787
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2639..2660
		I-set	2685..2776	CDD:400151
		Ig strand B	2702..2706	CDD:409353
		Ig strand C	2715..2719	CDD:409353
		Ig strand E	2742..2746	CDD:409353
		Ig strand F	2756..2761	CDD:409353
		Ig strand G	2769..2772	CDD:409353
		STKc_Trio_C	2788..3050	CDD:271015
trio	NP_651960.2	SEC14	13..152	CDD:214706	6/27 (22%)
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
Blue background indicates that the domain is not in the aligned region.