DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TRIO and trio

DIOPT Version :9

Sequence 1:NP_009049.2 Gene:TRIO / 7204 HGNCID:12303 Length:3097 Species:Homo sapiens
Sequence 2:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster


Alignment Length:2340 Identity:1029/2340 - (43%)
Similarity:1459/2340 - (62%) Gaps:196/2340 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    58 DEMKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEVCKR 122
            |..:|.|:|.:|:|:|.:|:||||:||||:|.|||....||::.||||||:|||..|||:.....
  Fly     2 DGQRARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNL 66

Human   123 GFTVIVDMRGSK--WDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVS 185
            |||||:||||:.  ..::|.:||:|||.|...||..:||||||||||||.:..|.|::|||..||
  Fly    67 GFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYKFETTTVS 131

Human   186 LEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAKKELPQDL 250
            :|.|.|:|:..|||.:|:|...|:|::|.:.|:|.||:...|..|..|:::||:.|.:.:..:|:
  Fly   132 IESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDV 196

Human   251 EGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRI---------------------------QS 288
            ..||:.|:.|::::||:.|.||||||::|:|||.:|                           |.
  Fly   197 PLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQ 261

Human   289 SESFPKKNSGSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMF 353
            |:...:..|..||.|:...:.|....::.:|:.::.|..:|..:|:|||||||.||||||.||||
  Fly   262 SQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMF 326

Human   354 DWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQ 418
            |||.||:.:|..||.|||.::..|..||.:|..||:..|||.|||:||::||.||:||.|||:|.
  Fly   327 DWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQH 391

Human   419 IRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKAC-GEVDLPSELQDLED 482
            |:.:|.:|::.||.|||.||||:.:|.:|.:||.|||:|.::|.||..|| ....|||::|.||.
  Fly   392 IKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLET 456

Human   483 AIHHHQGIYEHITLAYSEVSQDGKSLLDKL-------QRPLTPGSSDSLTAS------------- 527
            ||..||.:||.:..||:||....|.||.:|       .:|..||..|....|             
  Fly   457 AIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNP 521

Human   528 -ANYSKAVHHVLDVIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLS 591
             |:||:...|||.|||::|.|.|.||..|...::||||.|.|.:||:||:|||||::||||.||.
  Fly   522 AADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLR 586

Human   592 KHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRI 656
            |:||:|::.|:||..|..|::||.||||||:||.|||.||::||::||.||.|||..|.:||.::
  Fly   587 KNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELELQV 651

Human   657 QDFVRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDD---VYAESVEAVQDLIKRFGQ-QQ 717
            ..|..|||||:..|||:|.|:||.|::..|:::|:.::..|   :..|::|.::.:::::.: ||
  Fly   652 GSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQ 716

Human   718 QTTLQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKL 782
            ::::.|.:..|.:||.|:|::|....:.|    ..||..:|..|::|::.:.::|||:..||.:.
  Fly   717 ESSVNVCLTTISQGEALLQEMRSLEYADN----TGSIAALEATLEKLNKQKVELEELWSARKFRA 777

Human   783 ELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMNNLTFDVIH 847
            :|.|:||.|||||..:...:|.|::||  |..|. :.|...|||.::.|.:....:.|.|::|:.
  Fly   778 DLILRLRYFERDARLLSVQMEMWSEEL--QHADL-SRDYQKAEQLIRMHNESVTEIQNATYEVVQ 839

Human   848 QGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHL 912
            |||||||.   .:.:|...:.|.......|::.||:||.|::.:|:..:|..|..|||.|||...
  Fly   840 QGQDLLQL---FENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQF 901

Human   913 QAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQA 977
            |.:..||:.||||||:||.|..:|.:||||||||::.|||||.||||||.||:||:.:|:|::.|
  Fly   902 QNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINA 966

Human   978 NHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWC- 1041
            ||||...|.:.::.|...||||:...|:|.|||.||:.||||:|||||||:|||:|||||:||| 
  Fly   967 NHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCD 1031

Human  1042 --GGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSV------NMPGM 1098
              ||:||      ...:..:||||.|||||||||||||||.|:.||||.:|:..      |..| 
  Fly  1032 GGGGSDK------AQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEG- 1089

Human  1099 VTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLS 1163
                     .||:.|::|..:||:||.|||:||:.||||||:|:||||||||:||||:.||.|||
  Fly  1090 ---------HVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLS 1145

Human  1164 THTS-TGSSIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKR 1227
            :.:: .|.|.:.|:.|||||.||:.|||:|:|||||||||||...|||||||::||:.|.:||:|
  Fly  1146 SRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQR 1210

Human  1228 YRDFSLRMEKYRTSLEKALGIS-------SDSNKSSKSLQLDIIPASIPGSEVKLRDA---AHEL 1282
            |:|||.||:.|...|||:||:|       ||.|.|..|...|  ..|.|..|.||..:   ..|:
  Fly  1211 YKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGD--RHSDPTLEAKLNSSNKENKEI 1273

Human  1283 NEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEI 1347
            ||||||||||||||||||:|||:|||.||..|:..:|.|..:| :.:|..::.:|.:||||::||
  Fly  1274 NEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAG-KSVPSALIGQEDVIFGNIKEI 1337

Human  1348 YEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRH 1412
            :.||..|||:||||||.:||||||||||||.||.|||.||||||.|..|:::|.||:|:|:|:|.
  Fly  1338 HHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQRRL 1402

Human  1413 GLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFD 1477
            .:.:.:.:|||||||||||||||||:||:||||..||||:||||||:|||:||||||||:||..|
  Fly  1403 EVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDAMHLSLLENCD 1467

Human  1478 ENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSEL 1542
            .:::..||::||::||.||.|.:|||||||.:||||:.|:|:||||:|: ..||.:||||.|:::
  Fly  1468 VSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESN-VVKYQFKSKLMTTDM 1531

Human  1543 GVTEHVEGDPCKFALWVGRTP-TSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIH 1606
            |:|||:|||..|||:|.||:| .||.:|||||:|:|.||.|:|.:|||:||..  ..|.   .:.
  Fly  1532 GITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETC--FSGT---SLT 1591

Human  1607 IPKTAPATRQKGRRDGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACN 1671
            :||:........:|...|||.|.. .:..|..|:||..|.||.|||...|..|.|.|:.|:.|.:
  Fly  1592 LPKSPAKHSGSSQRSSRDLDEQLT-ENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATS 1655

Human  1672 -SNELTIRRGQTVEVLERP-HDKPDWCLVRTT---DRSPAAEGLVPCGSLCIAHSRSSMEMEGIF 1731
             ||||::.:||.||::|.| ..:||:||||..   |.:...|||||...|        ....|  
  Fly  1656 GSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVL--------KPPPG-- 1710

Human  1732 NHKDSLSVSSNDASPPASVAS-LQPHMIGAQS---SPGPKRPGNTLRKWLTSPVRRLSSGKADGH 1792
            :||.....::|.||...|..| :|.....:::   |...||.|.:.|.||  |:..         
  Fly  1711 SHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWL--PLMN--------- 1764

Human  1793 VKKLAHKHKKSREVRKSADAGSQKDSDDSAATPQ---DETVEERGRNEGLSSGTLSKSSS----- 1849
             :|...|...|:.:.|       |.|:.:..|||   :|..|::.:..|.|..|:..||.     
  Fly  1765 -RKGTDKPPSSKPLVK-------KPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSST 1821

Human  1850 --SGMQSCGEEEGEEGADAVPLPPPM-AIQQHSLLQPD----SQDDKASSRLLVRPTSSETPSAA 1907
              .|....|:.|.:|.. .:.||||| .||:..|:...    ::|.|.||..:..|...:    .
  Fly  1822 QHPGGAGAGDYEPDEEV-GLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMD----G 1881

Human  1908 ELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEME---ERKSSSLKR 1969
            ..:|.|||:||:  ..|...|:..||.|....   |.|.|....|....||..   ..|:::||:
  Fly  1882 NPLSEIEEIVKT--TTEQHESNSRVDGGGGVE---NASTNGHGRSHDNNDESHTAVSDKAAALKK 1941

Human  1970 RHYVLQELVETERDYVRDLGYVVEGYMALMKEDG----VPDDMK-GKDKIVFGNIHQIYDWHRDF 2029
            |..|..||:.||..||:||..:|.|||..:....    :|:|:| ||.|:||.||..||:|||||
  Fly  1942 RQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDF 2006

Human  2030 FLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLT 2094
            ||..|..|.:.|..||.|..:...:..:|..||.|||.||:|||.:.. :|:.::|:|||||.|:
  Fly  2007 FLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHYQ-YFDSIRQKLGHRLDLS 2070

Human  2095 DLLIKPVQRIMKYQLLLKDFLKYSKKASL--DTSELERAVEVMCIVPRRCNDMMNVGR-LQGFDG 2156
            :|:|||||||.||:||:|:.:|.::.|.|  :...|:.|.:.|.:|.:..||||.|.| ||.|||
  Fly  2071 NLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDG 2135

Human  2157 KIVAQGKLLLQDTF-LVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV 2220
            :|.|||.||:|... .|.|    ...:.||.::|||:||:||::....|..::.|.|.:::.|::
  Fly  2136 EITAQGSLLMQGPMNCVVD----AAQKHRELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQL 2196

Human  2221 SCLCLEENVENDPCKFALTSRTGDVVE-TFILHSSSPSVRQTWIHEINQILENQRNFLNALTSPI 2284
            :.:.::|..:   |:|.:.|....:.| |.|..::|......|...:|:||:.|.:.:..|::|:
  Fly  2197 NHMQMKELGD---CRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIFMLSNPL 2258

Human  2285  2284
              Fly  2259  2258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRIONP_009049.2 SEC14 69..204 CDD:214706 75/136 (55%)
SPEC 230..445 CDD:238103 99/241 (41%)
Spectrin 1 311..418 55/106 (52%)
SPEC 341..566 CDD:238103 115/246 (47%)
Spectrin 2 538..644 61/105 (58%)
SPEC 567..783 CDD:238103 91/219 (42%)
SPEC 787..1014 CDD:238103 100/226 (44%)
Spectrin 3 878..984 57/105 (54%)
SPEC 908..1137 CDD:238103 126/237 (53%)
Spectrin 4 1109..1216 69/107 (64%)
SPEC 1143..1243 CDD:197544 62/100 (62%)
RhoGEF 1295..1465 CDD:238091 105/169 (62%)
PH1_Kalirin_Trio_like 1472..1594 CDD:270060 69/122 (57%)
PH 1505..1590 CDD:278594 50/85 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1601..1650 14/48 (29%)
SH3_Kalirin_1 1659..1718 CDD:212786 28/63 (44%)
SH3-RhoG_link 1715..1972 CDD:293215 72/278 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1779..1906 34/141 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1927..1965 11/40 (28%)
RhoGEF 1970..2143 CDD:238091 78/179 (44%)
PH2_Kalirin_Trio_p63RhoGEF 2148..2286 CDD:270061 44/140 (31%)
PH 2175..2271 CDD:278594 24/96 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2287..2552
SH3_Kalirin_2 2555..2613 CDD:212787
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2639..2660
I-set 2685..2776 CDD:254352
Ig 2699..2776 CDD:299845
STKc_Trio_C 2788..3050 CDD:271015
S_TKc 2796..3050 CDD:214567
trioNP_651960.2 SEC14 13..152 CDD:214706 76/138 (55%)
SPEC 314..>468 CDD:238103 83/153 (54%)
SPEC 563..778 CDD:238103 91/218 (42%)
SPEC 782..997 CDD:238103 96/220 (44%)
SPEC 897..1119 CDD:238103 126/237 (53%)
SPEC 1125..1226 CDD:197544 62/100 (62%)
RhoGEF 1287..1456 CDD:279015 105/169 (62%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 69/122 (57%)
PH 1495..1580 CDD:278594 50/85 (59%)
SH3_Kalirin_1 1643..1707 CDD:212786 28/71 (39%)
RhoGEF 1945..2122 CDD:279015 77/177 (44%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 42/136 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 236 1.000 Domainoid score I2348
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20847
Inparanoid 1 1.050 1775 1.000 Inparanoid score I69
Isobase 1 0.950 - 0 Normalized mean entropy S5434
OMA 1 1.010 - - QHG46230
OrthoDB 1 1.010 - - D4513at33208
OrthoFinder 1 1.000 - - FOG0002562
OrthoInspector 1 1.000 - - otm42181
orthoMCL 1 0.900 - - OOG6_103664
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1686
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.690

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