Protein Alignment TRIO and CaMKI

DIOPT Version :9

• Sequence 1: NP_009049.2
• Gene: TRIO / 7204
• HGNCID: 12303
• Length: 3097
• Species: Homo sapiens
• Sequence 2: NP_524622.1
• Gene: CaMKI / 43792
• FlyBaseID: FBgn0016126
• Length: 405
• Species: Drosophila melanogaster
• Alignment Length: 352
• Identity: 103/352 - (29%)
• Similarity: 162/352 - (46%)
• Gaps: 54/352 - (15%)

Human  2764 DMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTK-RAVATKFV 2827
            |.|..:.:..|:.|...:         :.:..|:....||.|.||.|:..:.|.:. ...|.|.:
  Fly     8 DSGKKAKAKDLKELNKQV---------SIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKII 63

Human  2828 NKKLM--KRDQVTHELGILQ---------------SLQHPLLVGLLDTFETPTSYILVLEMADQG 2875
            :||.:  |.:.:.:|:.:|:               .|.||.:|.||:|:|..:...||:|:...|
  Fly    64 DKKALKGKEESLENEIRVLRRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGG 128

Human  2876 RLLDCVVRWGSLTEGKIRAHL-GEVLEAVRYLHNCRIAHLDLKPENILV----DESLAKPTIKLA 2935
            .|.|.:|..||.|| |..:|| .::||||.|:|...:.|.||||||:|.    |:|    .|.::
  Fly   129 ELFDRIVEKGSYTE-KDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDS----KIMIS 188

Human  2936 DFGDAVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEET 3000
            ||| ..::..:..:....|.|.:.|||::...|.....|.||:||::|:||.|..||.|::....
  Fly   189 DFG-LSKMEDSGIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANL 252

Human  3001 CLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGVLDTSR 3065
            ...|.:.||.|...|:..:|:.||.|:..|:.....||.:...||...|:......|..:..|
  Fly   253 FAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWISGNEASSRNIHGT-- 315

Human  3066 LTSFIERRKHQNDVRPIRSIKNFLQSR 3092
               ..|:.|           |||.:||
  Fly   316 ---VSEQLK-----------KNFAKSR 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIO	NP_009049.2	SEC14	69..204	CDD:214706
		SPEC	230..445	CDD:238103
		Spectrin 1	311..418
		SPEC	341..566	CDD:238103
		Spectrin 2	538..644
		SPEC	567..783	CDD:238103
		SPEC	787..1014	CDD:238103
		Spectrin 3	878..984
		SPEC	908..1137	CDD:238103
		Spectrin 4	1109..1216
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		PH	1505..1590	CDD:278594
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1601..1650
		SH3_Kalirin_1	1659..1718	CDD:212786
		SH3-RhoG_link	1715..1972	CDD:293215
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1779..1906
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1927..1965
		RhoGEF	1970..2143	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061
		PH	2175..2271	CDD:278594
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2287..2552
		SH3_Kalirin_2	2555..2613	CDD:212787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2639..2660
		I-set	2685..2776	CDD:254352	3/11 (27%)
		Ig	2699..2776	CDD:299845	3/11 (27%)
		STKc_Trio_C	2788..3050	CDD:271015	89/284 (31%)
		S_TKc	2796..3050	CDD:214567	89/276 (32%)
CaMKI	NP_524622.1	STKc_CaMKI	27..301	CDD:270985	89/279 (32%)
		S_TKc	31..302	CDD:214567	89/276 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810