DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TRIO and CG10177

DIOPT Version :9

Sequence 1:	NP_009049.2	Gene:	TRIO / 7204	HGNCID:	12303	Length:	3097	Species:	Homo sapiens
Sequence 2:	NP_651150.1	Gene:	CG10177 / 42772	FlyBaseID:	FBgn0039083	Length:	411	Species:	Drosophila melanogaster

Alignment Length:	255	Identity:	77/255 - (30%)
Similarity:	117/255 - (45%)	Gaps:	43/255 - (16%)

- Green bases have known domain annotations that are detailed below.

Human  2816 KGTKRAVAT----KFVNKKLMKRDQ--VTHELGILQSLQ-HPLLVGLLDTFETPTSYILVLEMAD 2873
            :|..||..|    |.|||:....|:  ...|..:|:.|| ||.::.|:.|.|.......|||.
  Fly   165 RGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAEVLRQLQSHPNIIELMYTVEDERYMYTVLEH-- 227

Human  2874 QGRLLDC-----VVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAK---P 2930
                |||     :.:.|.|:|...|:.:...:.|:.::|..::.|.|:||||:||..|..|   .
  Fly   228 ----LDCNMQKVIQKRGILSEADARSVMRCTVSALAHMHQLQVIHRDIKPENLLVCSSSGKWNFK 288

Human  2931 TIKLADFGDAVQLNTTYY----IHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSP 2991
            .:|:|:|..|     |||    ::...|.|.:.|||:|..:......|:||:||..:.:|.|..|
  Fly   289 MVKVANFDLA-----TYYRGSKLYVRCGTPCYMAPEMIAMSGYDYQVDSWSLGVTLFYMLCGKMP 348

Human  2992 FLDDSVEETCLN-------ICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKR-PSAAL 3043
            |     ...|.|       |.....::|.|....:|.:|.:.:..||..||:.| |.|.|
  Fly   349 F-----ASACKNSKEIYAAIMSGGPTYPKDMESVMSPEATQLIDGLLVSDPSYRVPIAEL 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRIO	NP_009049.2	SEC14	69..204	CDD:214706
		SPEC	230..445	CDD:238103
		Spectrin 1	311..418
		SPEC	341..566	CDD:238103
		Spectrin 2	538..644
		SPEC	567..783	CDD:238103
		SPEC	787..1014	CDD:238103
		Spectrin 3	878..984
		SPEC	908..1137	CDD:238103
		Spectrin 4	1109..1216
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		PH	1505..1590	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1601..1650
		SH3_Kalirin_1	1659..1718	CDD:212786
		SH3-RhoG_link	1715..1972	CDD:293215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1779..1906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1927..1965
		RhoGEF	1970..2143	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061
		PH	2175..2271	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2287..2552
		SH3_Kalirin_2	2555..2613	CDD:212787
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2639..2660
		I-set	2685..2776	CDD:254352
		Ig	2699..2776	CDD:299845
		STKc_Trio_C	2788..3050	CDD:271015	77/255 (30%)
		S_TKc	2796..3050	CDD:214567	77/255 (30%)
CG10177	NP_651150.1	DCX	18..108	CDD:214711
		S_TKc	164..409	CDD:214567	77/255 (30%)
		PKc_like	164..403	CDD:304357	76/253 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900