Protein Alignment TRIO and CG15611

DIOPT Version :10

• Sequence 1: NP_009049.2
• Gene: TRIO / 7204
• HGNCID: 12303
• Length: 3097
• Species: Homo sapiens
• Sequence 2: NP_611189.2
• Gene: CG15611 / 36930
• FlyBaseID: FBgn0034194
• Length: 508
• Species: Drosophila melanogaster
• Alignment Length: 524
• Identity: 110/524 - (20%)
• Similarity: 214/524 - (40%)
• Gaps: 117/524 - (22%)

Human  1809 SADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPM 1873
            :||.|...|..|.|...:...:|.:..:..::: ||.||.:|   |.|:.|
  Fly    39 NADNGKSIDVVDKAPAKECPLLESQSPSSPIAT-TLPKSQAS---SNGKLE-------------- 85

Human  1874 AIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQ--GD 1936
              :|.|||..||....:|........::.:|:           .::.......||..|..:  ||
  Fly    86 --KQISLLDSDSGISLSSINTCSTTAANSSPT-----------YRAPNGFHSFPSHTLSFETLGD 137

Human  1937 SSSPSFNPSDNSL-LSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMK 2000
                .::..:::| |.:..|.|:.|...|   |:..:::.||::||.:||.:|...:..|..|..
  Fly   138 ----EYHEDEDTLSLENLFPCDQTEIYAS---KKISFIIDELIQTEVNYVNNLKKGMLNYGQLKD 195

Human  2001 EDGVPDDMKG--KDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKH--ERRLHMYIAY 2061
            .:.:|:.:.|  |.|::.|||.:|.:.|....|..:.:...|.:.|...|..|  :...:.|:::
  Fly   196 VEDLPEALSGETKQKMLLGNIKEILELHEKEILPLMLRNQRDLKGLFDEFAAHFEKNSFYCYVSF 260

Human  2062 CQNKPKSEHIVSE---YIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASL 2123
            ...|..|..:..:   ::.|:...:|.:||    :...|::|:||:.:|.|||:.|:....|:.:
  Fly   261 TMGKKSSMQLRQDNRLWLQTYQTQIKDKLG----IDSFLVQPIQRLTRYPLLLQQFISEFYKSGI 321

Human  2124 D-----------TSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDA 2177
            .           .:.:.||::|:    .:..::.|:..|...|       .|.|.:....|:.||
  Fly   322 SCKPVLTAVCKLETRMRRALDVV----NQAEEIPNIEELNELD-------VLQLGNFRRATEFDA 375

Human  2178 GLLPRCRERR--IFLFEQIVIFSE---------------------PLDKKKGFSMPGFLFKNSIK 2219
            ...|..::.|  :|||::.::.:|                     |||.         :..|:.|
  Fly   376 QHFPTRKKYRSKVFLFDRCLVCTEVRKKRLAYRQHYNWEHVELQRPLDS---------VSSNANK 431

Human  2220 VSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWI---HEINQILENQRNFLNALT 2281
            :..|.:::....        |..|...|.:...::..||.:.|:   |:|.:|..|:....|..:
  Fly   432 IINLLVKQEEGG--------SSVGSKREEYSFMAAEASVVKQWLQATHKIIEIARNEHARRNTFS 488

Human  2282 SPIE 2285
            .|::
  Fly   489 LPMD 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIO	NP_009049.2	SEC14	69..204	CDD:214706
		SPEC	230..445	CDD:238103
		Spectrin 1	311..418
		SPEC	341..566	CDD:238103
		Spectrin 2	538..644
		SPEC	567..783	CDD:238103
		SPEC	787..1014	CDD:238103
		Spectrin 3	878..984
		SPEC	908..1137	CDD:238103
		Spectrin 4	1109..1216
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1601..1650
		SH3_Kalirin_1	1659..1718	CDD:212786
		SH3-RhoG_link	1715..1972	CDD:465196	35/165 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1779..1906		23/96 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1927..1965		10/40 (25%)
		RhoGEF	1970..2143	CDD:238091	43/190 (23%)
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061	31/164 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2287..2552
		PHA03247	<2330..2540	CDD:223021
		SH3_Kalirin_2	2555..2613	CDD:212787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2639..2660
		I-set	2685..2776	CDD:400151
		Ig strand B	2702..2706	CDD:409353
		Ig strand C	2715..2719	CDD:409353
		Ig strand E	2742..2746	CDD:409353
		Ig strand F	2756..2761	CDD:409353
		Ig strand G	2769..2772	CDD:409353
		STKc_Trio_C	2788..3050	CDD:271015
CG15611	NP_611189.2	RhoGEF	167..313	CDD:470622	38/149 (26%)