Protein Alignment TRIO and CG46491

DIOPT Version :10

• Sequence 1: NP_009049.2
• Gene: TRIO / 7204
• HGNCID: 12303
• Length: 3097
• Species: Homo sapiens
• Sequence 2: NP_611188.3
• Gene: CG46491 / 36929
• FlyBaseID: FBgn0287631
• Length: 682
• Species: Drosophila melanogaster
• Alignment Length: 655
• Identity: 155/655 - (23%)
• Similarity: 249/655 - (38%)
• Gaps: 163/655 - (24%)

Human  1718 IAHSRSSMEMEGIFNHKDSL---SVSSND-ASPPASVAS------------------------LQ 1754
            |:|..:..|     .|..:|   ::.||| |.|.:||:|                        |:
  Fly    31 ISHQAAEQE-----RHSSTLVSSNLESNDVARPVSSVSSSSSSIQLSYSVNSDTDSSYRHRSLLK 90

Human  1755 PHM------IGAQSSP----GPKRPGNTLRKWLTSPVRRLSSGKAD-GHVKKLAHKHKKSREVRK 1808
            .|.      :|.:|:|    .|:.|...|.. :...|.|..:.:.: ..:|:..|..|.....|.
  Fly    91 MHEAESVGGLGTESTPESPMSPQTPDPALLD-VRQKVHRFEAFRTNICFIKQERHSLKLLENRRH 154

Human  1809 SADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCG--EEEGEEGADAVPLPP 1871
            .:.....:|.....|||     ..|.|..||.|...|:|||......|  |...|:..|
  Fly   155 PSFEDQSEDHHTPPATP-----PRRIRLPGLGSRGSSRSSSIPSFQAGIHEVRSEDEVD------ 208

Human  1872 PMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGD 1936
                 |.|..:.||. ..|...|:|..||...||        ||:..||:..:....|:..||..
  Fly   209 -----QISDFETDSH-TAAEEYLVVDTTSEVVPS--------EEVADSKVDQQQVQRSISADQSK 259

Human  1937 S-----------------SSPS-----FNPSDNSLL----SSSSPIDEME----ERKSSSLKRRH 1971
            .                 |:|.     ...::..|:    |...|.||.|    |.:..|.|..|
  Fly   260 EALTLPLKMRNDFPRNYRSTPRRKTEIIGTTNEHLVGKFHSVYQPKDEEEEVEIELRDKSDKCVH 324

Human  1972 YVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEK 2036
            .:|:||::||..||.:|...:|.|..:.:...:|..::||...:||||.||.::|||.||..|::
  Fly   325 PILEELIKTEEAYVNNLFTGIENYGNIFQRKDLPLGLRGKKYDLFGNIEQIAEFHRDEFLPMLQR 389

Human  2037 CLEDPEKLGSLFVK--HERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIK 2099
            ...|.::|...|::  .:...:.|:.:..||.||..:...| ..:|..::.....:|.:...|::
  Fly   390 NRRDLKRLFDEFLQFLDQHCFYGYVIFTMNKQKSLKLCDLY-KNYFTSIRLERDDKLGINSFLVQ 453

Human  2100 PVQRIMKYQLLLKDFLK-YSKKASLDTSELERAVEVMCIVPRR-------------CNDMMNVGR 2150
            |:||:.:|.|||..|:. :.|...:....|   :|..|.:.:|             .||:::.
  Fly   454 PIQRMARYPLLLTQFINTFFKNRDIVMKPL---IESCCRLEKRLRALLTTTNESEIINDIVDC-- 513

Human  2151 LQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFK 2215
               .:..:..|||....:.|.|.|..   |.|....::|:|::.:|::|...|       ..||.
  Fly   514 ---HEFNVYYQGKFRKVNEFQVLDHK---LKRSYRSKVFIFDKCIIYTEIKGK-------NLLFH 565

Human  2216 N---------SIKVSCLCL-EENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQIL 2270
            .         |.|.....| .|..:...|:|     |.|.|:..|           |:..|..::
  Fly   566 GRYPCEHIGISAKTKSFTLYYERRKQQECEF-----TADPVQIAI-----------WLDLIRDMI 614

Human  2271 ENQRN 2275
            .|..|
  Fly   615 NNYAN 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIO	NP_009049.2	SEC14	69..204	CDD:214706
		SPEC	230..445	CDD:238103
		Spectrin 1	311..418
		SPEC	341..566	CDD:238103
		Spectrin 2	538..644
		SPEC	567..783	CDD:238103
		SPEC	787..1014	CDD:238103
		Spectrin 3	878..984
		SPEC	908..1137	CDD:238103
		Spectrin 4	1109..1216
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1601..1650
		SH3_Kalirin_1	1659..1718	CDD:212786	155/655 (24%)
		SH3-RhoG_link	1715..1972	CDD:465196	73/324 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1779..1906		33/129 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1927..1965		12/67 (18%)
		RhoGEF	1970..2143	CDD:238091	51/188 (27%)
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061	29/138 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2287..2552
		PHA03247	<2330..2540	CDD:223021
		SH3_Kalirin_2	2555..2613	CDD:212787
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2639..2660
		I-set	2685..2776	CDD:400151
		Ig strand B	2702..2706	CDD:409353
		Ig strand C	2715..2719	CDD:409353
		Ig strand E	2742..2746	CDD:409353
		Ig strand F	2756..2761	CDD:409353
		Ig strand G	2769..2772	CDD:409353
		STKc_Trio_C	2788..3050	CDD:271015
CG46491	NP_611188.3	RhoGEF	326..469	CDD:459876	44/143 (31%)
		ROM1	<438..>660	CDD:227709	46/216 (21%)