DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TRIO and zormin

DIOPT Version :9

Sequence 1:NP_009049.2 Gene:TRIO / 7204 HGNCID:12303 Length:3097 Species:Homo sapiens
Sequence 2:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster


Alignment Length:2792 Identity:521/2792 - (18%)
Similarity:899/2792 - (32%) Gaps:905/2792 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   220 FEDYISNATHMLSRLEELQDILAKKEL--PQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKL 282
            |.|.::.....:.:||     ||.:|.  |.|:...:..:....||:..::...:..|. :|.:|
  Fly   214 FHDKMTQCFRKMDQLE-----LACEETLHPPDVPRVQEFLNRFKQLRIDMLTGVMAALK-DGNEL 272

Human   283 LQRIQSSESFPKKNSGSGN--ADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLF 345
            |.:::..|.....::...:  .|....:.:|...|:.||..|..|...|..||::::||..|.|.
  Fly   273 LAQLEELEKLETLDTRPEHIKRDATRAVHQVQQWLEALHDRRNSLELAWQTRKIQMEQCLALALL 337

Human   346 EQDAEKMFDWITHNKGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVE 410
            .::...: :.......:.||:...:|.....|.|:.|::..:....:.:.....:|.....::..
  Fly   338 GRELVDL-EAALQQARMELNTMYSLGECEHTANEMLTKYREWKQQALLLRDRALKITRAKEKVQS 401

Human   411 SGHYASQQIRQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPS 475
            :||:..:.....|..:..........:|:|...|..|..|..|||..:|.::........|.||.
  Fly   402 AGHFTEEDACARAYAVLSGCTEHLDLVDQREHWLHQSREFFAKAEHTVSVLEKLELELTSVKLPP 466

Human   476 ELQDLEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLDV 540
                      |....|    ..:|:|.:|.::..::..| |..|..|.:..:...::.|..||| 
  Fly   467 ----------HSPESY----AMFSKVDRDVRNFTEEPLR-LGYGILDEVGRTQPETQGVKRVLD- 515

Human   541 IHEVLHHQRQLENIWQHRKVRL----------HQRLQ--LCVFQQDVQQVLDWIENHGEAFLSKH 593
                     :|||    |||.:          .|::|  |..|.....::|.|:...|:..|.:.
  Fly   516 ---------ELEN----RKVYIQGICANSSEDQQKVQRALSEFLNHHNELLAWLRASGQHQLQQS 567

Human   594 TGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEA----AEQLAQTGECDPEEIYQAAHQLED 654
            ..:|.:|.:|:....:|.:..:..:......:.|||:    .|.|:.....|.:...::.|:...
  Fly   568 VDMGGNLQQAKQFLLQHHELMQDLEIKGELINLLLESIKVHLESLSPQERYDVDSKAESLHKHWI 632

Human   655 RIQDFV-RRVEQRKILLDMSVSFHTHVKELWTWLEELQKEL------------------------ 694
            .::|.| :||:...:|:|    |.....||.:.|:.||::|                        
  Fly   633 ELKDLVLKRVDYVSLLID----FFELANELSSQLDNLQRQLQQTPDEHKLQFLQATWTGIASTFG 693

Human   695 -------------LDDVYAE---SVEAVQDLIKRFGQQQ---QTTLQVTVNVIKEGEDLIQQLRD 740
                         :.|.|.|   |.:|||:.:..|.::|   .::|:.....|.|..: ::.|.:
  Fly   694 ELKSRGQRFINLKIVDPYLETKSSAQAVQETLNDFSKRQVDVTSSLENWTTSIAEKRE-VEYLLE 757

Human   741 SAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKLELFLQLRIFERDAI-DIISDLES 804
            ..:|.|:          |||.:. .:..:|:..:|..:.:..:   ||.|..|:.: ::|.|:|.
  Fly   758 KVMSDNE----------ETVAKS-TQVDTQLYPVFTSQSVDSK---QLLISTREKLTNVIQDIER 808

Human   805 WNDELSQQMN---DFDTED---LTIAEQRLQHHADKALTMNNLTFDVIHQGQDLLQYVNEVQASG 863
            ..||:.|::.   ...|:|   |...||          .:|||.  ::....|.::|        
  Fly   809 AQDEIQQRIQTTLGIQTKDQPSLAKIEQ----------VINNLR--MLKAKLDGIKY-------- 853

Human   864 VELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHLQAEVKQVLGWIRNGES 928
                     |..|.|:.:::|                  ||..||||      :::..:....:.
  Fly   854 ---------DYRTLVESVIQF------------------LENIVQLR------REIDDYFARQQK 885

Human   929 MLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIR----DCA 989
            ...:|         |::...|||:|:.          |...|..:::..:...:|.:|    ..|
  Fly   886 EPASG---------ADRSIAEHEKFRD----------QCMDKFRSLITQSELLIDRVRVLEPPGA 931

Human   990 EKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWCGGADKLGPNSETD 1054
            .::.:   ..:||:.:.|:|     .|...|....|.||.||:..:...|.          .:.|
  Fly   932 REIDT---DRILKLLENLRL-----HFESNSSARMSTLERLEKIEQFRSDL----------EDID 978

Human  1055 HVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRN-SVNMPGMVTHIKAPEQQVKNILNELFQ 1118
            .....:|:.|.:..........|.:...:..:|..|. ..:||          :|:|:..::  :
  Fly   979 RSLDSVSQQLHEINNQSVDSLAAAKTTSLAFEYFERTIECSMP----------RQLKSTRHQ--R 1031

Human  1119 RENRVLHYWTMRKRRLDQCQQYVVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHE 1183
            |..:..|...:.::|:::      |..|..|.|...:...|.|:.            .||.|.:|
  Fly  1032 RWGQTAHTIELLEKRIEK------FTESTSQQLFITNPESERYVK------------DELRKLNE 1078

Human  1184 EFQITAKQTKERVKLLIQLADGF--CEKGHAHAAEIKKCVTAVDKR--YRDFSLR-------MEK 1237
            ::|....|.|::.|.|.|..|.|  .||..|...||....|:|..:  |...|:.       :|.
  Fly  1079 KWQSFKDQVKQKRKSLNQATDFFEVVEKIDAEYREISYFYTSVSNKVPYLRDSVEAGNLVNDIEN 1143

Human  1238 YRTSLEKALGISSDS--------NKSSKSLQLDIIPASIPGSEVKLRDAAHELNEEKRKSARRKE 1294
            |.||.|.||....||        ||.| ||..|::  :|..|.:||:...:.:.|..::..|:||
  Fly  1144 YVTSREAALRSKLDSASQCAHDMNKVS-SLYNDVM--NIFQSFIKLKMDINVVQERLKQEQRQKE 1205

Human  1295 FIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKEL 1359
                   |.|    ||.|:                                   :......:||.
  Fly  1206 -------QRE----RDARD-----------------------------------QAEREKAIKEA 1224

Human  1360 EKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIK 1424
            |..|:|..                                       |.|.|  |.|......|:
  Fly  1225 EAKERLHR---------------------------------------EEQSR--LENQRQQAAIE 1248

Human  1425 PVQR-ITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQG---- 1484
            ..|| :...:|.|:|.....||.:      |:.:.....|...|...:..|   |.:..|.    
  Fly  1249 QAQRELAARELALREQAVREEEAR------LQAIREQATREQLAREQAARE---EELRIQSLRDI 1304

Human  1485 -----ELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGV 1544
                 |:.||   .:.|.:|.||:..|..:            .:::..|||...::::...|:  
  Fly  1305 ARREEEVRLQ---NIRDEETRIRREEEERI------------RRENESRSKREEEARIQREEI-- 1352

Human  1545 TEHVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPK 1609
                                  .::......::.::...::||:.||..:|..:.....|:....
  Fly  1353 ----------------------TRLQTLRDQVDQQRIVTENIRKDIQVNSIFTELRYASPLFTRP 1395

Human  1610 TAPATRQKGRRDGEDLDSQGDGSSQP------DTISIASRTSQNTLDSDKLSGGCELTVVIHDFT 1668
            ...|..::|  |....:.:..|:.:|      |.|||.:.:...| ..||  |.|.| |:...|.
  Fly  1396 LKDAVSREG--DRFVFECEVTGTPEPAVEWFKDGISIQTNSDYKT-TFDK--GICRL-VIEETFA 1454

Human  1669 A---------------CNSN-ELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGL------- 1710
            |               |::| .|::|.......|..|.      ::|......|.||.       
  Fly  1455 ADSARFSCRASNLVGTCDTNATLSVRENAAEVQLVPPR------ILRFLQSGKATEGSSFQFACV 1513

Human  1711 ---VPCGSL-------CIAHS----------RSSMEMEGIFNHKDSLSVSSNDASPPASV----A 1751
               ||..::       ||..|          .::::.|.:|...|::...|  ||.||.:    |
  Fly  1514 VAGVPLPTVQWFKNDKCIDDSPDYVISYNNGEATLKFEEVFLEDDAVYTCS--ASNPAGIEHCSA 1576

Human  1752 SLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHKHKKSREVRKSADAGSQK 1816
            ||....:.....|..|.|              ||:..|           :..::::..|..|   
  Fly  1577 SLIVEPLEPTELPSFKVP--------------LSNAMA-----------RVGQKIKLEAIVG--- 1613

Human  1817 DSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQH--- 1878
                  ..|:.|..       .|.:|.                        |..|..:..::   
  Fly  1614 ------GIPRPEVY-------WLHNGK------------------------PFQPRDSKYEYGRV 1641

Human  1879 SLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFN 1943
            :|:.|.:..:.|.|.:|     |....|.|..::...:||.::..|                   
  Fly  1642 TLIIPQAYPNDAGSYVL-----SAKNLAGEAYTSCNVIVKGRLPNE------------------- 1682

Human  1944 PSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDM 2008
            .||:.:.|...||....          |..|:::...|...||                      
  Fly  1683 TSDSEMASDIEPIKPAV----------HLPLKDVSIFEGKPVR---------------------- 1715

Human  2009 KGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVS 2073
              .|.::.|.......|:.:      |:.:::...:..||               ...:...|:.
  Fly  1716 --LDCVIVGQPEPEVIWYHN------ERPVKESADVQLLF---------------QGDRCSLIIQ 1757

Human  2074 EYIDTFFEDLKQRLGH----------------RLQLTDL-LIKPVQRIM------------KYQL 2109
            |   .:.||    .||                .|::|.| ..:|..|..            |::.
  Fly  1758 E---VYQED----AGHYKVVAINSAGEASSSCELKVTPLNQAEPATRAQAERQSLPKDSQPKFER 1815

Human  2110 LLKDFLKYSKKASLDTSELERAV-EVMCI--VPRRCNDMMNVGRLQGFDGKIVAQG-------KL 2164
            ||.|.|         ..|.|:.| ||...  .|......:....|| .|.:|..|.       ||
  Fly  1816 LLSDVL---------ADEGEQVVLEVQASGDQPLTAQWFLTNKELQ-LDQRITTQSDSELGVFKL 1870

Human  2165 LLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV-----SCLC 2224
            :|.:   |:..|.|:             ..|..:.|....|.||   .|...|:..     |...
  Fly  1871 ILNN---VSGDDKGV-------------YTVKVTNPAGDAKCFS---HLIVKSVNAPENRRSSQS 1916

Human  2225 LEENVENDPC---KFALTSRTGDVVETF---ILHSSSPSVRQTWIHEINQILENQRNFLNALTSP 2283
            ..|.:|...|   |...:.:.|::.|..   .:....|:.:..|             |.|  ..|
  Fly  1917 SVEIIERHQCPEFKELFSDKQGEIDEVIKFECIVKGKPTPKVHW-------------FFN--DQP 1966

Human  2284 IEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPSRIPQPVRHH 2348
            :.                                 ||:       ...|||..|.....|.:.|.
  Fly  1967 VH---------------------------------GHN-------FLVSTSGERQVLTIQKLTHD 1991

Human  2349 PPVLVSSAASSQA-EADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADAEGSEREAEPIPKM 2412
            ....:|..|.::| :|..::..:..|..||           |.|.....:....:|.....|.|.
  Fly  1992 AVGKISCVAENEAGKATCVAFLNIRGSGLP-----------ASSDVQTVSQEHNTESSRVTIKKQ 2045

Human  2413 KVLESPRKGAANASGSSPDAPAKDARASL--GTLPLGKPRAGAASPLNSPLSSAVPSLGKEPFPP 2475
            ....:......:..|::|......:.|.:  ....||:.|.....      |.....|.|.. ..
  Fly  2046 TFTTTSTSQVNSYEGNAPQTEVHHSSAHIDQSLKQLGQQRPEIVE------SHHYQELHKSK-EM 2103

Human  2476 SSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQ-TPRHAAP--GKDTDRMSTCSSASEQSV 2537
            |||..:..|| |.|.:|.|:...:...|.....|:|: .||...|  ||..|:            
  Fly  2104 SSPTVQQKSF-SFIQSSGANGQSAVAIPDSPTRLRREIAPRFTTPLSGKIVDQ------------ 2155

Human  2538 QSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQILASNQQNMFLVFRAATDQCPAA 2602
                  |::.|..:                    :|.|                       .|:.
  Fly  2156 ------GADVSMEA--------------------IYDG-----------------------FPSP 2171

Human  2603 EGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLRKKSEKKDKDGKREGKLENGYRKSREGLS 2667
            |             :.||...|.|.:..  ||  |:..|..:...:.|:.|..:.|  :.....|
  Fly  2172 E-------------IKVEKNGGQLFEDA--HT--RISNKCNRVTIELKQVGVGDAG--RYAVTAS 2217

Human  2668 NKV-----SVKLLNPNYIYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKG------- 2720
            |.|     :..|:....|:  ||.|...|.....:.||.:.:...|.|.|:.::||..       
  Fly  2218 NTVGQSTSTADLVVKKTIF--PPVFGRRLQAQVSKKGEKLTMEVEVTGLPEPTVTWLKDDKPLKD 2280

Human  2721 ---PEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGP 2779
               .||..|.....|          .|.|....|.|.|.|...|.|..|.|.|.|...:|.|
  Fly  2281 AGISEHRLLAQGNSY----------RLIIEKAQTTDSGKYMVRATNAGGEAKSIADCAILEP 2332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRIONP_009049.2 SEC14 69..204 CDD:214706
SPEC 230..445 CDD:238103 40/218 (18%)
Spectrin 1 311..418 22/106 (21%)
SPEC 341..566 CDD:238103 44/234 (19%)
Spectrin 2 538..644 26/121 (21%)
SPEC 567..783 CDD:238103 51/265 (19%)
SPEC 787..1014 CDD:238103 45/237 (19%)
Spectrin 3 878..984 16/105 (15%)
SPEC 908..1137 CDD:238103 39/233 (17%)
Spectrin 4 1109..1216 25/108 (23%)
SPEC 1143..1243 CDD:197544 31/110 (28%)
RhoGEF 1295..1465 CDD:238091 25/170 (15%)
PH1_Kalirin_Trio_like 1472..1594 CDD:270060 19/130 (15%)
PH 1505..1590 CDD:278594 7/84 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1601..1650 11/54 (20%)
SH3_Kalirin_1 1659..1718 CDD:212786 16/91 (18%)
SH3-RhoG_link 1715..1972 CDD:293215 44/280 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1779..1906 17/129 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1927..1965 5/37 (14%)
RhoGEF 1970..2143 CDD:238091 33/204 (16%)
PH2_Kalirin_Trio_p63RhoGEF 2148..2286 CDD:270061 30/155 (19%)
PH 2175..2271 CDD:278594 18/106 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2287..2552 49/270 (18%)
SH3_Kalirin_2 2555..2613 CDD:212787 4/57 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2639..2660 4/20 (20%)
I-set 2685..2776 CDD:254352 26/100 (26%)
Ig 2699..2776 CDD:299845 23/86 (27%)
STKc_Trio_C 2788..3050 CDD:271015
S_TKc 2796..3050 CDD:214567
zorminNP_001261317.1 SPEC 126..332 CDD:238103 27/123 (22%)
SPEC <504..641 CDD:295325 31/150 (21%)
COG1340 960..1298 CDD:224259 96/476 (20%)
RILP-like <1190..1315 CDD:304877 36/223 (16%)
MAP7 1233..1365 CDD:283355 31/181 (17%)
I-set 1390..1479 CDD:254352 22/94 (23%)
IGc2 1403..1469 CDD:197706 17/71 (24%)
I-set 1491..1580 CDD:254352 21/96 (22%)
IGc2 1504..1570 CDD:197706 14/67 (21%)
I-set 1589..1675 CDD:254352 22/155 (14%)
Ig 1605..1675 CDD:299845 16/114 (14%)
I-set 1702..1786 CDD:254352 17/135 (13%)
Ig 1713..1786 CDD:299845 15/124 (12%)
I-set 1811..1902 CDD:254352 28/119 (24%)
Ig 1828..1892 CDD:143165 17/80 (21%)
I-set 1927..2015 CDD:254352 20/142 (14%)
IGc2 1940..2005 CDD:197706 16/119 (13%)
I-set 2142..2231 CDD:254352 27/168 (16%)
Ig 2158..2231 CDD:299845 20/134 (15%)
I-set 2238..2325 CDD:254352 25/96 (26%)
Ig 2254..2324 CDD:299845 19/79 (24%)
I-set 3566..3655 CDD:254352
Ig 3583..3650 CDD:143165
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.