DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT3 and CCT3

DIOPT Version :9

Sequence 1:	NP_005989.3	Gene:	CCT3 / 7203	HGNCID:	1616	Length:	545	Species:	Homo sapiens
Sequence 2:	NP_001189236.1	Gene:	CCT3 / 42029	FlyBaseID:	FBgn0015019	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	378/547 - (69%)
Similarity:	455/547 - (83%)	Gaps:	10/547 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     3 GHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAIL 67
            |.:|:||||||||||||||||..||.|.|.|||:|||||||::|:|||:||||||||||||||||
  Fly     4 GQQPILVLSQNTKRESGRKVQLENIQAGKAIADVIRTCLGPQAMLKMLMDPMGGIVMTNDGNAIL 68

Human    68 REIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDD 132
            |||.||||||||||||:|||||||||||||||:||||||:.||.||:||:||||:|.|||:||:|
  Fly    69 REITVQHPAAKSMIEIARTQDEEVGDGTTSVIVLAGEMLAAAEPFLQQQIHPTVIIRAYREALED 133

Human   133 MISTLK-KISIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIK 196
            ::..|: ::||.:|:.|...|.:::.:.:.||.|.:||.||..||||||:.|...||||.|:|||
  Fly   134 IVGHLQSQLSIQLDVKDKAKMADVVKACVGTKFIGKWSDLAVKIALDAVETVTLSENGRLEVDIK 198

Human   197 KYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITRE 261
            :||:|||||||.||:||||:|||||||||||:|||.|:||||||||.|||||||||||::||..|
  Fly   199 RYAKVEKIPGGAIEESCVLKGVMINKDVTHPKMRRLIENPRIVLLDCSLEYKKGESQTNVEIIGE 263

Human   262 EDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARA 326
            :||||:||:|||::|::|.|||.:|||:|.||||:||||||||::|.||||||:|||||.|||||
  Fly   264 QDFTRMLQIEEEFVQRICADIIAVKPDLVFTEKGVSDLAQHYLLKAGITAIRRLRKTDNLRIARA 328

Human   327 CGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNL 391
            |||.||:|.|||.|.||||||||.|:||||||||||:|:||:|||||||||||||:||:|.||||
  Fly   329 CGATIVNRTEELTEKDVGTGAGLFEVKKIGDEYFTFVTECKEPKACTILLRGASKDILNETERNL 393

Human   392 QDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCG 456
            |||:.|.||::|:|:||.||||.|||.:..||.|.      .:.||.|||.|||:|||||.||||
  Fly   394 QDALHVARNLVLEPRLVAGGGAVEMAASQLLTRKQ------VKGPYTAVAHALEIIPRTLAQNCG 452

Human   457 ASTIRLLTSLRAK---HTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLR 518
            |:|||.||:||||   ||.:....||::||:|.:|||....|||||||||||||||||||:||||
  Fly   453 ANTIRALTALRAKHASHTGDGVCAWGIDGESGEIVDMNVKNIWEPLAVKLQTYKTAVETAILLLR 517

Human   519 IDDIVSGHKKKGDDQSRQGGAPDAGQE 545
            |||||||.||:|.::.....|...|||
  Fly   518 IDDIVSGSKKRGGNEPTNPAAMAQGQE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT3	NP_005989.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		17/20 (85%)
		chap_CCT_gamma	6..529	CDD:274085	371/526 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545		5/18 (28%)
CCT3	NP_001189236.1	chap_CCT_gamma	7..528	CDD:274085	370/524 (71%)
CCT3	NP_001189236.1	TCP1_gamma	7..524	CDD:239453	366/520 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140623
Domainoid	1	1.000	697	1.000	Domainoid score	I129
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4373
Inparanoid	1	1.050	753	1.000	Inparanoid score	I571
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53994
OrthoDB	1	1.010	-	-		D207515at33208
OrthoFinder	1	1.000	-	-		FOG0004601
OrthoInspector	1	1.000	-	-		oto89885
orthoMCL	1	0.900	-	-		OOG6_100235
Panther	1	1.100	-	-	LDO	PTHR11353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1488
SonicParanoid	1	1.000	-	-		X3218
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800